1. GPCR/G Protein
    Neuronal Signaling
    JAK/STAT Signaling
    Stem Cell/Wnt
  2. Dopamine Receptor
    Adrenergic Receptor
    STAT
  3. Pimozide D4

Pimozide D4 (Synonyms: R6238 D4)

Cat. No.: HY-12987S
Handling Instructions

Pimozide D4 (R6238 D4) is a deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5.

For research use only. We do not sell to patients.

Pimozide D4 Chemical Structure

Pimozide D4 Chemical Structure

CAS No. : 1803193-57-8

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Description

Pimozide D4 (R6238 D4) is a deuterium labeled Pimozide. Pimozide is a dopamine receptor antagonist, with Kis of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor, with a Ki of 39 nM; Pimozide also inhibits STAT3 and STAT5[1][2][3].

IC50 & Target[1][2][3]

Dopamine D2 receptor

1.4 nM (Ki)

opamine D3 receptor

2.5 nM (Ki)

opamine D1 receptor

588 nM (Ki)

α1-adrenoceptor

39 nM (Ki)

STAT3

 

STAT5

 

Clinical Trial
Molecular Weight

465.57

Formula

C₂₈H₂₅D₄F₂N₃O

CAS No.

1803193-57-8

SMILES

O=C1NC2=CC=CC=C2N1C3CCN(CCCC(C4=CC=C(F)C=C4)C5=C([2H])C([2H])=C(F)C([2H])=C5[2H])CC3

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Pimozide D4R6238 D4Pimozide D 4Pimozide D-4Dopamine ReceptorAdrenergic ReceptorSTATBeta ReceptorDeuteriumlabeledPimozideα1-adrenoceptordopamineInhibitorinhibitorinhibit

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Pimozide D4
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