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Results for "

AKR

" in MedChemExpress (MCE) Product Catalog:

By Targets:	17β-HSD (15) Aldose Reductase (49) Amino acid Transporter (1) Androgen Receptor (1) Antibiotic (1) Apoptosis (5) Autophagy (1) Bacterial (1) Biochemical Assay Reagents (2) Cytochrome P450 (2) DNA Alkylator/Crosslinker (1) Drug Derivative (1) Drug Metabolite (2) E3 Ligase Ligand-Linker Conjugates (1) Endogenous Metabolite (4) ERK (2) Estrogen Receptor/ERR (1) FGFR (1) Fluorescent Dye (2) Glucocorticoid Receptor (1) GPR84 (1) Heme Oxygenase (HO) (2) Interleukin Related (1) Isotope-Labeled Compounds (2) JAK (1) JNK (1) Keap1-Nrf2 (2) Ligands for Target Protein for PROTAC (1) MHC (2) NF-κB (2) PDGFR (1) PERK (1) Phosphatase (2) PPAR (1) PROTACs (1) RAR/RXR (1) Ras (1) Reactive Oxygen Species (ROS) (6) Reference Standards (9) Small Interfering RNA (siRNA) (23) SOD (2) STAT (4) Thrombopoietin Receptor (7) TNF Receptor (1) Topoisomerase (1)
By Research Areas:	Cancer (60) Cardiovascular Disease (4) Endocrinology (4) Infection (1) Inflammation/Immunology (16) Metabolic Disease (16) Neurological Disease (10)
Click Chemistry:	Azide (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (8) Mouse Pre-designed siRNA Sets (4) Human Pre-designed siRNA Sets (11) siRNAs (23)

113

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0376

Liquiritin Maximum Cited Publications 15 Publications Verification	Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology Cancer
Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive *AKR1C1* inhibitor with IC₅₀s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .

HY-P99930

Efruxifermin 2 Publications Verification AKR-001; AMG-876	FGFR	Metabolic Disease
Efruxifermin is an Fc-FGF21 fusion protein (human IgG1 Fc domain linked to a modified human FGF21). Efruxifermin has prolonged half-life and enhanced receptor affinity compared with native human FGF21. Efruxifermin can be used for the research of non-alcoholic steatohepatitis .

HY-133708

β-Glucogallin 1 Publications Verification Glucogallin; 1-O-Galloyl-β-D-glucose	Aldose Reductase Reactive Oxygen Species (ROS) NF-κB PDGFR SOD	Neurological Disease Metabolic Disease
β-Glucogallin is an orally active and selective aldose reductase (AKR1B1) inhibitor with an IC₅₀ value of 58 μM when using Glyceraldehyde (HY-128748) as AKR1B1 substrate. β-Glucogallin reduces ROS, PDGF, RAGE, and NF-κB. β-Glucogallin increases SOD. β-Glucogallin has antioxidant and hepatoprotective effects. β-Glucogallin can be used in retinal research .

HY-105185

Fidarestat 3 Publications Verification SNK 860	Aldose Reductase	Metabolic Disease
Fidarestat (SNK 860) is an inhibitor of aldose reductase, with IC₅₀s of 26 nM, 33 μM, and 1.8 μM for aldose reductase, AKR1B10 and V301L AKR1B10, respectively; Fidarestat (SNK 860) has the potential to treat diabetic disease.

HY-113114

Tetrahydrocortisone	Endogenous Metabolite Glucocorticoid Receptor	Metabolic Disease Inflammation/Immunology
Tetrahydrocortisone is a corticosteroid catalyzed from endogenous glucocorticoids by AKR1D1 (5_β-reductase). Its formation is mediated by AKR1D1 and regulated by the glucocorticoid receptor (GR). As one of the final products of glucocorticoid inactivation metabolism, Tetrahydrocortisone participates in the maintenance of glucocorticoid metabolic homeostasis in vivo. Tetrahydrocortisone can be used for mechanistic studies of metabolic diseases such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes, and also serves as a biomarker for in vivo AKR1D1 activity and glucocorticoid metabolic status .

HY-13463

Avatrombopag 5 Publications Verification AKR-501; E5501; YM477	Thrombopoietin Receptor	Inflammation/Immunology Cancer
Avatrombopag (AKR-501) is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC₅₀=3.3 nM). Avatrombopag mimics the biological activities of TPO. Avatrombopag increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A .

HY-19903

ASP-9521 3 Publications Verification	17β-HSD	Cancer
ASP-9521 is a potent, selective and orally available *AKR1C3* inhibitor with an IC₅₀ of 11 nM for human AKR1C3.

HY-114009

AKR1C1-IN-1 2 Publications Verification	Aldose Reductase	Neurological Disease
AKR1C1-IN-1 is a potent and selective inhibitor of human 20α-hydroxysteroid dehydrogenase (AKR1C1), with a K_i value of 4 nM for AKR1C1 .

HY-107379

AKR1C3-IN-1 1 Publications Verification	17β-HSD	Others
AKR1C3-IN-1 is a potent, highly selective inhibitor of *AKR1C3, with an IC₅₀* of 13 nM.

HY-139696

AKR1B10-IN-1	Aldose Reductase	Cancer
AKR1B10-IN-1 is a potent inhibitor of *AKR1B10* (Aldo-Keto Reductase 1B10) with an IC₅₀ of 3.5 nM. AKR1B10-IN-1 suppresses proliferation, metastasis, and Cisplatin (CDDP) resistance of lung cancer cells .

HY-124573

(R)-Odafosfamide OBI-3424; TH-3424; (R)-AST-3424	DNA Alkylator/Crosslinker	Cancer
(R)-Odafosfamide (OBI-3424) is a proagent that is selectively converted by AKR1C3 (aldo-keto reductase 1C3) to a potent DNA-alkylating agent. (R)-Odafosfamide can be used for hepatocellular carcinoma, castrate-resistant prostate cancer, and acute lymphoblastic leukemia (ALL) research .

HY-150644

S07-2010 1 Publications Verification	Aldose Reductase	Cancer
S07-2010 is a potent pan-AKR1C (aldo-keto reductase family 1 member C) inhibitor, with IC₅₀ values of 0.19, 0.36, 0.47, and 0.73 μM for *AKR1C3, AKR1C4, AKR1C1* and *AKR1C2, respectively. S07-2010 induces apoptosis* in A549/DDP cells. S07-2010 strengthens the cytotoxicity of chemotherapeutic agents in drug-resistant cells. S07-2010 significantly inhibits the proliferation of drug-resistant cells .

HY-P3333

KSPWFTTL	MHC	Inflammation/Immunology Cancer
KSPWFTTL is an immunodominant Kb-restricted epitope from the p15E transmembrane protein. KSPWFTTL can restore susceptibility of a tumor line to anti-AKR/Gross MuLV cytotoxic T lymphocytes .

HY-13463A

Avatrombopag maleate 5 Publications Verification AKR-501 maleate; E5501 maleate; YM477 maleate	Thrombopoietin Receptor Cytochrome P450 ERK STAT	Inflammation/Immunology Cancer
Avatrombopag (AKR-501) maleate is an orally active, non-peptide thrombopoietin receptor (TPO receptor) agonist (EC₅₀: 3.3 nM). Avatrombopag maleate mimics the biological activity of TPO. Avatrombopag maleate increases platelet production by activating intracellular signaling systems and promotes the production of platelets and megakaryocytes from hematopoietic precursor cells. Avatrombopag maleate is a substrate for cytochrome P450 (CYP) 2C9 and CYP3A .

HY-D1341

Coumberone 2 Publications Verification	Fluorescent Dye	Cancer
Coumberone is a metabolic fluorogenic probe, and isoform-selective substrate for all AKR1C isoforms. Coumberone can be reduced by all four members of the AKR1C family to its fluorescent alcohol coumberol. Coumberone can be used for the research of AKR1C .

HY-N2282

Zingiberen newsaponin Zingiberensis newsaponin	Aldose Reductase JAK STAT Autophagy Apoptosis NF-κB SOD Reactive Oxygen Species (ROS)	Cardiovascular Disease Neurological Disease Inflammation/Immunology Cancer
Zingiberen Newsaponin (Zingiberensis newsaponin) is an orally active type of steroid saponin compound. Zingiberen Newsaponin exerts anti-hepatocellular carcinoma (HCC) effects by inhibiting autophagy and the *AKR1C1/JAK2/STAT3* pathway. Zingiberen Newsaponin activates oxidative stress (upregulates ROS and MDA) and mitochondrial pathways, promoting cancer cell apoptosis. Zingiberen Newsaponin alleviates cerebral ischemia-reperfusion (I/R) injury by decreasing the concentration of pro-inflammatory cytokines and inhibits NF-κB. Zingiberen Newsaponin can enhance the activity of SOD, eliminate free radicals and protect nerve cells. Zingiberen Newsaponin induces platelet aggregation .

HY-138557

AKR1C3-IN-4	17β-HSD	Cancer
AKR1C3-IN-4 is a potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ of 0.56 μM. AKR1C3-IN-4 has the potential for castrate resistant prostate cancer (CRPC) research .

HY-109154

Obafistat	Aldose Reductase	Inflammation/Immunology
Obafistat is a potent aldo-keto reductase *AKR1C3* inhibitor with an IC₅₀ of 1.2 nM for human AKR1C3 (patent WO2017202817A1, example 4) .

HY-D1342

Coumberol	Fluorescent Dye	Cancer
Coumberol is a fluorescent substrate of AKR1C3 protein. Coumberol can be used for the research of AKR1C3 .

HY-152189

S19-1035	17β-HSD	Cancer
S19-1035 is a highly potent and specific aldo-keto reductase 1C3 (AKR1C3) inhibitor. S19-1035 inhibits AKR1C3 with an IC₅₀ value of 3.04 nM. S19-1035 can be used for the research of tumor .

HY-172314

ACHM-025	Aldose Reductase Drug Derivative	Cancer
ACHM-025 is a prodrug, which is selectively activated by AKR1C3 to a nitrogen mustard DNA alkylating agent. ACHM-025 can be used for the research of cancer, such as leukemia .

HY-152188

AKR1C3-IN-9	Aldose Reductase	Cancer
AKR1C3-IN-9 is a selective inhibitor of Aldo-keto Reductase 1C3 (AKR1C3) with an IC₅₀ value of 8.92 nM. AKR1C3-IN-9 significantly reverses the Doxorubicin (HY-15142A) (DOX) resistance in a resistant breast cancer cell line .

HY-RS17235

Akr1b1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Akr1b1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Akr1b1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Akr1b1 Mouse Pre-designed siRNA Set A Akr1b1 Mouse Pre-designed siRNA Set A

HY-116170

SN34037	Aldose Reductase	Cancer
SN34037 is a specific inhibitor of Aldo-keto reductase 1C3 (AKR1C3, EC 1.1.1.188) with the ability to inhibit the cytotoxic activity of PR-104A. SN34037-sensitive coumberone reduction provides a rapid and specific assay for AKR1C3 activity. SN34037 inhibits the aerobic cytotoxicity of PR-104A in TF1 erythroleukemia cells with high AKR1C3 expression, but not in Nalm6 pre-B acute lymphoblastic leukemia cells with low AKR1C3 expression .

HY-149040

Odafosfamide (S)-OBI-3424; (S)-TH-3424; AST-3424	17β-HSD	Cancer
Odafosfamide ((S)-OBI-3424) is a highly selective prodrug bis-alkylating agent activated by aldehyde-keto reductase 1C3 (AKR1C3(). Odafosfamide is highly cytotoxic to cell lines with high AKR1C3 expression. Odafosfamide exhibits antitumor activity in a variety of tumors with high AKR1C3 expression (such as liver cancer, non-small cell lung cancer, and leukemia). Odafosfamide can be used in cancer research .

HY-156701

BAY-1128688	Aldose Reductase	Metabolic Disease Endocrinology
BAY-1128688 is a potent, orally active and selective *AKR1C3* inhibitor with IC₅₀ < 2 nM. BAY-1128688 shows high selectivity over related AKR1C enzymes (1C1, 1C2, 1C4) and AKR1D1. BAY-1128688 exhibits no relevant activity at major nuclear hormone receptors. BAY-1128688 reduces endometriotic lesions in the marmoset monkey endometriosis model. BAY-1128688 can be used for endometriosis research .

HY-176084

RJG-2051	Aldose Reductase	Cancer
RJG-2051 is a selective covalent aldo-keto reductase family 1 member C3 (AKR1C3) inhibitor with an IC₅₀ value of 13 nM. RJG-2051 interferes with the metabolic process of substrates such as androgens, estrogens, and prostaglandins by AKR1C3. RJG-2051 is promising for research of cancers .

HY-118819

5-Bromo-3-phenyl salicylic acid	Aldose Reductase	Neurological Disease Cancer
5-Bromo-3-phenyl salicylic acid is a selective inhibitor for human 20α-hydroxysteroid dehydrogenase (AKR1C1) with K_i of 140 nM .

HY-N8549A

5-Dihydrocortisone	Endogenous Metabolite	Metabolic Disease
5-Dihydrocortisone is a 5-Dihydrocortisone with mixture of isomers. 5β-Dihydrocortisone is a sterol metabolite of cortisone by 5β-reductase (AKR1D1) in liver

HY-RS00532

AKR1B1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AKR1B1 Human Pre-designed siRNA Set A contains three designed siRNAs for AKR1B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AKR1B1 Human Pre-designed siRNA Set A AKR1B1 Human Pre-designed siRNA Set A

HY-RS00533

AKR1B10 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AKR1B10 Human Pre-designed siRNA Set A contains three designed siRNAs for AKR1B10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AKR1B10 Human Pre-designed siRNA Set A AKR1B10 Human Pre-designed siRNA Set A

HY-13463B

Avatrombopag hydrochloride 5 Publications Verification AKR-501 hydrochloride; E5501 hydrochloride; YM477 hydrochloride	Thrombopoietin Receptor	Cardiovascular Disease Cancer
Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC₅₀=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A .

HY-163940

LX1	Aldose Reductase Androgen Receptor	Cancer
LX1 is an anti-prostate cancer compound that targets androgen receptor (AR), AR variants and steroidogenic enzyme *AKR1C3. LX1 inhibits the enzymatic activity of AKR1C3, reduces the conversion of androstenedione to testosterone and reduces the expression of AR and AR-V7* and downregulates their target genes. LX1 overcomes the resistance of tumor cells to Enzalutamide (HY-70002), and the combination with Enzalutamide (HY-70002) further inhibits tumor growth .

HY-P3333A

KSPWFTTL TFA	MHC	Inflammation/Immunology Cancer
KSPWFTTL TFA is an immunodominant Kb-restricted epitope from the p15E transmembrane protein. KSPWFTTL TFA can restore susceptibility of a tumor line to anti-AKR/Gross MuLV cytotoxic T lymphocytes .

HY-W010617

2-Cyclohexen-1-ol	Biochemical Assay Reagents	Inflammation/Immunology
2-Cyclohexen-1-ol is a biochemical reagent. 2-Cyclohexen-1-ol is the oxidation substrate of mouse aldo-keto reductase *AKR1C12, with a K_m* of 1080 μM and a K_cat of 13 min ^-1, showing low catalytic efficiency .

HY-146573

AKR1C3-IN-6	Aldose Reductase 17β-HSD	Cancer
AKR1C3-IN-6 (Compound 1) is a potent, selective *AKR1C3* inhibitor with IC₅₀ values of 0.31 μM and 73.23 μM against AKR1C3 and *AKR1C2, respectively. AKR*1C3-IN-6 shows antitumor activity .

HY-155502

AKR1C3-IN-10	Aldose Reductase	Cancer
AKR1C3-IN-10 (compound 5r) is a selective *AKR1C3* inhibitor (IC₅₀=51 nM). AKR1C3-IN-10 shows good activity in a prostate cancer xenograft model .

HY-161839

AKR1C2/3-IN-1	Aldose Reductase	Cancer
AKR1C2/3-IN-1 (compound 3a) is a potent *AKR1C2* and *AKR1C3* inhibitor with IC₅₀ values of 90, 50 nM, respectively. AKR1C2/3-IN-1 can be used as a radiation sensitizer and as a potentiator of chemotherapy cytotoxicity .

HY-163609

*PROTAC AKR1C3 degrader-1*	PROTACs Aldose Reductase	Cancer
PROTAC AKR1C3 degrader-1 (compound 5) is a potent *AKR1C3* PROTAC degrader. PROTAC AKR1C3 degrader-1 decreases the protein expression of AKR1C3, AKR1C1/2, and ARv7. PROTAC AKR1C3 degrader-1 has the potential for the research of prostate cancer. (Blue:ubiquitin E3 ligase cereblon ligand (HY-A0003), Black: linker (HY-163647); Pink: AKR1C3 inhibitor (HY-163610)) .

HY-13463R

Avatrombopag (Standard) AKR-501 (Standard); E5501 (Standard); YM477 (Standard)	Reference Standards Thrombopoietin Receptor	Inflammation/Immunology Cancer
Avatrombopag (Standard) is the analytical standard of Avatrombopag. This product is intended for research and analytical applications. Avatrombopag (AKR-501) is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC₅₀=3.3 nM). Avatrombopag mimics the biological activities of TPO. Avatrombopag increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A .

HY-13463BS

Avatrombopag-d8 hydrochloride AKR-501-d8 hydrochloride; E5501-d8 hydrochloride; YM477-d8 hydrochloride	Isotope-Labeled Compounds Thrombopoietin Receptor	Cardiovascular Disease
Avatrombopag-d₈ (hydrochloride) is deuterium labeled Avatrombopag (hydrochloride). Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC₅₀=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A .

HY-W008567

N-Deschlorobenzoyl indomethacin	Drug Metabolite	Others
N-Deschlorobenzoyl indomethacin (Compound 18), the primary metabolite of indomethacin (HY-14397), lacks the N-p-chlorobenzoyl group in its structure. Consequently, N-Deschlorobenzoyl indomethacin loses inhibitory activity against *AKR1C2* and *AKR1C3* (AKR1C2 IC₅₀ =100 μM, *AKR1C3* IC₅₀ >100 μM), exhibiting no selectivity .

HY-177415

JSD26	Aldose Reductase	Endocrinology
JSD26 is a selective and orally active SCoR2 (AKR1A1) inhibitor with an IC₅₀ of 93 nM. JSD26 has 10-fold selectivity for SCoR2 versus AKR1B1. JSD26 can be used for the study acute kidney injury (AKI) .

HY-175331

ALR2-IN-7	Aldose Reductase	Metabolic Disease Cancer
ALR2-IN-7 (Compound 5a) is a highly potent and selective aldose reductase (ALR2/AKR1B1) inhibitor (K_i=8.71 nM). ALR2-IN-7 is promising for research of diabetic complications (e.g., retinopathy, nephropathy) and cancers .

HY-171115

Pyrone-211	GPR84 Aldose Reductase	Metabolic Disease
Pyrone-211 is a potent GPR84 agonist and *AKR1C3* inhibitor. Pyrone-211 participates in an expanded polyamine pathway .

HY-163610

AKR1C3-IN-13	Ligands for Target Protein for PROTAC Aldose Reductase	Cancer
AKR1C3-IN-13 (Compound 4) is an *AKR1C3* inhibitor. AKR1C3-IN-13 degrades AKR1C3 in prostate cancer cells .

HY-173132

AKR1Cs-IN-1	Aldose Reductase	Cancer
AKR1Cs-IN-1 (Compound 29) is a potent and broad-spectrum inhibitor targeting members of the Aldo-Keto Reductase 1C family (AKR1C1-1C4). By simultaneously occupying the SP2 and SP3 pockets, it effectively inhibits multiple isoforms and disrupts metabolic pathways associated with drug resistance. In enzymatic activity assays, AKR1Cs-IN-1 exhibited significant inhibitory potency, with IC₅₀ values of 0.09, 0.28, 0.05, and 0.51 µM against *AKR1C1, AKR1C2, AKR1C3, and AKR1C4, respectively. In the doxorubicin (DOX)-resistant breast cancer cell line MCF-7/ADR, AKR1Cs-IN-1 showed remarkable resensitization effects and significantly enhanced the cytotoxicity of DOX. AKR*1Cs-IN-1 holds promise for research on overcoming drug resistance in breast cancer .

HY-146574

AKR1C3-IN-7	Aldose Reductase 17β-HSD	Cancer
AKR1C3-IN-7 (Compound 13) is a potent, selective *AKR1C3* inhibitor with an IC₅₀ of 0.19 μM. AKR1C3-IN-7 shows antitumor activity .

HY-146575

AKR1C3-IN-8	Aldose Reductase 17β-HSD	Cancer
AKR1C3-IN-8 (Compound 5) is a potent, selective *AKR1C3* inhibitor with an IC₅₀ of 0.069 μM. AKR1C3-IN-8 shows antitumor activity .

HY-157810

AKR1C3-IN-11	Aldose Reductase	Cancer
AKR1C3-IN-11 (Compound 6e) is a Aldo-keto reductase 1C3 (AKR1C3) inhibitor with an IC₅₀ of 2.0 μM. AKR1C3-IN-11 inhibit cell proliferation in combination with abiraterone (HY-70013). AKR1C3-IN-11 can be used for the research of prostate cancer .

Cat. No.	Product Name	Target	Research Area

HY-P3333

KSPWFTTL	MHC	Inflammation/Immunology Cancer
KSPWFTTL is an immunodominant Kb-restricted epitope from the p15E transmembrane protein. KSPWFTTL can restore susceptibility of a tumor line to anti-AKR/Gross MuLV cytotoxic T lymphocytes .

HY-P3333A

KSPWFTTL TFA	MHC	Inflammation/Immunology Cancer
KSPWFTTL TFA is an immunodominant Kb-restricted epitope from the p15E transmembrane protein. KSPWFTTL TFA can restore susceptibility of a tumor line to anti-AKR/Gross MuLV cytotoxic T lymphocytes .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99930

Efruxifermin 2 Publications Verification AKR-001; AMG-876	FGFR	Metabolic Disease
Efruxifermin is an Fc-FGF21 fusion protein (human IgG1 Fc domain linked to a modified human FGF21). Efruxifermin has prolonged half-life and enhanced receptor affinity compared with native human FGF21. Efruxifermin can be used for the research of non-alcoholic steatohepatitis .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0376

Liquiritin Maximum Cited Publications 15 Publications Verification	Monophenols Flavonoids Neurological Disease Classification of Application Fields Leguminosae Flavonones Phenols Plants Glycyrrhiza uralensis Fisch. Inflammation/Immunology Disease Research Fields Source Classification	Reactive Oxygen Species (ROS)
Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive *AKR1C1* inhibitor with IC₅₀s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .

HY-133708

β-Glucogallin 1 Publications Verification Glucogallin; 1-O-Galloyl-β-D-glucose	Structural Classification Phyllanthaceae Phenols Polyphenols Phyllanthus emblica L. Plants Source Classification	Aldose Reductase Reactive Oxygen Species (ROS) NF-κB PDGFR SOD
β-Glucogallin is an orally active and selective aldose reductase (AKR1B1) inhibitor with an IC₅₀ value of 58 μM when using Glyceraldehyde (HY-128748) as AKR1B1 substrate. β-Glucogallin reduces ROS, PDGF, RAGE, and NF-κB. β-Glucogallin increases SOD. β-Glucogallin has antioxidant and hepatoprotective effects. β-Glucogallin can be used in retinal research .

HY-113114

Tetrahydrocortisone	Structural Classification Classification of Application Fields Other Diseases Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite Glucocorticoid Receptor
Tetrahydrocortisone is a corticosteroid catalyzed from endogenous glucocorticoids by AKR1D1 (5_β-reductase). Its formation is mediated by AKR1D1 and regulated by the glucocorticoid receptor (GR). As one of the final products of glucocorticoid inactivation metabolism, Tetrahydrocortisone participates in the maintenance of glucocorticoid metabolic homeostasis in vivo. Tetrahydrocortisone can be used for mechanistic studies of metabolic diseases such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes, and also serves as a biomarker for in vivo AKR1D1 activity and glucocorticoid metabolic status .

HY-N0310

Soyasaponin Bb 1 Publications Verification	Triterpenes Classification of Application Fields Leguminosae Glycine max (L.) merr Terpenoids Plants Disease Research Fields Endocrinology Source Classification	Aldose Reductase Heme Oxygenase (HO) Reactive Oxygen Species (ROS) Apoptosis
Soyasaponin Bb is an orally active, covalent inducer of heme oxygenase HO-1 and an inhibitor of aldose reductase *AKR1B1. Soyasaponin Bb can regulate oxidative stress pathways, enhance antioxidant capacity, reduce reactive oxygen species (ROS) generation, and inhibit lipid peroxidation and hepatocyte apoptosis*. Soyasaponin Bb improves alcohol-induced hepatocyte membrane damage and liver function abnormalities, and improves Scopolamine (HY-N0296)-induced memory impairment. Soyasaponin Bb has antioxidant, hepatoprotective, and neuroprotective activities .

HY-N10361

Drupanin	Monophenols Animals Classification of Application Fields Phenols Disease Research Fields Source Classification Cancer	RAR/RXR PPAR Aldose Reductase
Drupanin is an orally active and selective AKR1C3 enzyme inhibitor and an RXRα agonist with an EC₅₀ value of 4.8 μM, which is found in green propolis. Drupanin also activates PPARγ moderately. Drupanin induces adipogenesis and elevates aP2 mRNA levels in 3T3-L1 fibroblasts Drupanin has the potential for the research of breast and prostate cancers .

HY-N0412

Sesamoside	Structural Classification Iridoids Classification of Application Fields Terpenoids Labiatae Phaseolus lunatus L. Plants Inflammation/Immunology Disease Research Fields Source Classification	PERK JNK TNF Receptor Interleukin Related
Sesamoside is an orally active anti-inflammatory, anti-hypoxic and analgesic agent. Sesamoside inhibits the phosphorylation of ERK and JNK, downregulates NLRP3 expression, restricts the nuclear localization of P65, regulates *AKR1B1* expression, and reduces the expression of TRPV1 gene in the spinal cord. Sesamoside reduces the production of TNF-α, IL-6, IL-1β, iNOS and NO, restores cellular metabolism and organ function, and alleviates cold and mechanical hyperalgesia. Sesamoside can be used in research related to septic shock, high-altitude pulmonary edema and neuropathic pain .

HY-N2282

Zingiberen newsaponin Zingiberensis newsaponin	Cardiovascular Disease Triterpenes Classification of Application Fields Terpenoids Dioscorea Zingiberensis C.H.Wright Plants Disease Research Fields Dioscoreaceae Source Classification	Aldose Reductase JAK STAT Autophagy Apoptosis NF-κB SOD Reactive Oxygen Species (ROS)
Zingiberen Newsaponin (Zingiberensis newsaponin) is an orally active type of steroid saponin compound. Zingiberen Newsaponin exerts anti-hepatocellular carcinoma (HCC) effects by inhibiting autophagy and the *AKR1C1/JAK2/STAT3* pathway. Zingiberen Newsaponin activates oxidative stress (upregulates ROS and MDA) and mitochondrial pathways, promoting cancer cell apoptosis. Zingiberen Newsaponin alleviates cerebral ischemia-reperfusion (I/R) injury by decreasing the concentration of pro-inflammatory cytokines and inhibits NF-κB. Zingiberen Newsaponin can enhance the activity of SOD, eliminate free radicals and protect nerve cells. Zingiberen Newsaponin induces platelet aggregation .

HY-N8549A

5-Dihydrocortisone	Classification of Application Fields Cardiacglycosides Metabolic Disease Endogenous metabolite Disease Research Fields Steroids Source Classification	Endogenous Metabolite
5-Dihydrocortisone is a 5-Dihydrocortisone with mixture of isomers. 5β-Dihydrocortisone is a sterol metabolite of cortisone by 5β-reductase (AKR1D1) in liver

HY-N0310R

Soyasaponin Bb (Standard)	Triterpenes Structural Classification Leguminosae Glycine max (L.) merr Terpenoids Plants Source Classification	Reference Standards Aldose Reductase Heme Oxygenase (HO) Reactive Oxygen Species (ROS) Apoptosis
Soyasaponin Bb (Standard) is the analytical standard of Soyasaponin Bb (HY-N0310). This product is intended for research and analytical applications. Soyasaponin Bb is an orally active, covalent inducer of heme oxygenase HO-1 and an inhibitor of aldose reductase *AKR1B1. Soyasaponin Bb can regulate oxidative stress pathways, enhance antioxidant capacity, reduce reactive oxygen species (ROS) generation, and inhibit lipid peroxidation and hepatocyte apoptosis*. Soyasaponin Bb improves alcohol-induced hepatocyte membrane damage and liver function abnormalities, and improves Scopolamine (HY-N0296)-induced memory impairment. Soyasaponin Bb has antioxidant, hepatoprotective, and neuroprotective activities .

HY-N0376R

Liquiritin (Standard)	Structural Classification Monophenols Flavonoids Leguminosae Flavonones Phenols Plants Glycyrrhiza uralensis Fisch. Source Classification	Reference Standards Reactive Oxygen Species (ROS)
Liquiritin (Standard) is the analytical standard of Liquiritin. This product is intended for research and analytical applications. Liquiritin, a flavonoid isolated from Glycyrrhiza uralensis, is a potent and competitive AKR1C1 inhibitor with IC50s of 0.62 μM, 0.61 μM, and 3.72μM for AKR1C1, AKR1C2 and AKR1C3, respectively. Liquiritin efficiently inhibits progesterone metabolism mediated by AKR1C1 in vivo . Liquiritin acts as an antioxidant and has neuroprotective, anti-cancer and anti-inflammatory activity .

HY-131586

3,7-Dihydroxyflavone Resogalangin	Flavonoids Flavones Plants Fabaceae Zuccagnia punctata Cav. Source Classification	17β-HSD Estrogen Receptor/ERR Aldose Reductase
3,7-Dihydroxyflavone (Resogalangin) is a flavonoid phytoestrogen, which can be isolated from Adenophora species. 3,7-Dihydroxyflavone is a modulator of estrogen receptors and an inhibitor of human progesterone metabolizing enzyme *AKR1C1* and fungal 17β-hydroxysteroid dehydrogenase and a redox inhibitor (IC₅₀=0.6 and 6.0 μM, respectively). 3,7-Dihydroxyflavone is a fluorescent binding substrate for human serum albumin (HSA) with excitation wavelengths of 370 nm (pH 7.4) and 350 nm (pH 3.5), respectively, and emission wavelength of 515 nm .

Species:	Human (8)
Tag:	His (6) Tag Free (3)
Source:	HEK293 (1) E. coli (8)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P75520

	AKR1C2 Protein, Human (His) AKR-1C2; Aldo-keto reductase family 1 member C2; DD-2; AKR1C2	Human	E. coli
	AKR1C2 protein: Cytoplasmic aldehyde-keto reductase, which uses NADH and NADPH to reduce ketosteroids to hydroxysteroids. AKR1C2 Protein, Human (His) is the recombinant human-derived AKR1C2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P7470

	AKR1C4 Protein, Human (His) rHuAldo-keto Reductase 1C4, His; AKR-1C4; Aldo-keto Reductase 1C4	Human	E. coli
	AKR1C4 Protein, Human (His) is a human recombinant AKR1C4 with a N-Terminal His-tag. AKR1C4 Protein, Human (His) is derived from E. coli and corresponding to the amino acids 1-323 of human Aldo-keto Reductase 1C4/AKR1C4.

HY-P75521

	AKR1B1 Protein, Human (His) Aldo-keto reductase family 1 member B1; AKR1B1; ALDR1; ALR2	Human	E. coli
	The AKR1B1 protein uses NADPH to reduce various carbonyl compounds to alcohols. AKR1B1 Protein, Human (His) is the recombinant human-derived AKR1B1 protein, expressed by E. coli , with N-10*His labeled tag.

HY-P703415

	AKR1A1 Protein, Sus scrofa ALR; ALR1	Others	E. coli
	AKR1A1 Protein, Sus scrofa is the recombinant AKR1A1, expressed by E. coli, with tag free labeled tag.

HY-P7469

	AKR1C2 Protein, Human rHuAldo-keto reductase family 1 member C2; AKR-1C2; Aldo-keto reductase family 1 member C2	Human	E. coli
	AKR1C2 Protein, Human is a recombinant human AKR1C2. AKR1C2 is a member of the aldo/keto reductase superfamily and has critical roles in the tumorigenesis and progression of malignant tumours.

HY-P7604

	AKR1C3 Protein, Human (HEK293, His) rHuAKR1C3, His; AKR1C3; HA1753; Dihydrodiol Dehydrogenase Type I; Indanol Dehydrogenase; Prostaglandin F Synthase	Human	HEK293
	AKR1C3 Protein, Human (HEK293, His) expresses in HEK293 cells with a His tag. Aldo-keto reductase family 1 member C3 (AKR1C3) is a steroidogenic enzyme that plays a crucial role in the conversion of adrenal androgen dehydroepiandrosterone (DHEA) into high-affinity ligands for the androgen receptor (testosterone [T] and dihydrotestosterone [DHT]).

HY-P76137

	AKR1A1 Protein, Human (His) Aldo-keto reductase family 1 member A1; Aldehyde reductase; Glucuronate reductase; ALDR1; ALR	Human	E. coli
	The AKR1A1 protein uses NADPH to reduce various carbonyl compounds to alcohols. AKR1A1 Protein, Human (His) is the recombinant human-derived AKR1A1 protein, expressed by E. coli , with N-His labeled tag.

HY-P701972

	Aldose-reductase Protein, Human AKR1B10; Aldo-keto reductase family 1 member B10; ARL-1; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase	Human	E. coli
	The Aldose-reductase protein reduces carbonyl-containing compounds to alcohols, including retinals. It detoxifies unsaturated carbonyls like crotonaldehyde and 4-hydroxynonenal, but lacks reductase activity towards glucose. Aldose-reductase Protein, Human is the recombinant human-derived Aldose-reductase protein, expressed by E. coli , with tag free.

HY-P701973

	Aldose-reductase Protein, Human (His) AKR1B10; Aldo-keto reductase family 1 member B10; ARL-1; Aldose reductase-like; Aldose reductase-related protein; ARP; hARP; Small intestine reductase; SI reductase	Human	E. coli
	The Aldose-reductase protein reduces carbonyl-containing compounds to alcohols, including retinals. It detoxifies unsaturated carbonyls like crotonaldehyde and 4-hydroxynonenal, but lacks reductase activity towards glucose. Aldose-reductase Protein, Human (His) is the recombinant human-derived Aldose-reductase protein, expressed by E. coli , with N-6*His labeled tag.

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Cat. No.	Product Name	Chemical Structure

HY-13463BS

Avatrombopag-d8 hydrochloride

Avatrombopag-d₈ (hydrochloride) is deuterium labeled Avatrombopag (hydrochloride). Avatrombopag (AKR-501) hydrochloride is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC₅₀=3.3 nM). Avatrombopag hydrochloride mimics the biological activities of TPO. Avatrombopag hydrochloride increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag hydrochloride is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A .

HY-W706737

N-Deschlorobenzoyl indomethacin-d3

N-Deschlorobenzoyl indomethacin-d₃ is the deuterium labeled N-Deschlorobenzoyl indomethacin (HY-W008567). N-Deschlorobenzoyl indomethacin (Compound 18), the primary metabolite of indomethacin (HY-14397), lacks the N-p-chlorobenzoyl group in its structure. Consequently, N-Deschlorobenzoyl indomethacin loses inhibitory activity against AKR1C2 and AKR1C3 (AKR1C2 IC₅₀ =100 μM, AKR1C3 IC₅₀ >100 μM), exhibiting no selectivity .

Host:	Mouse (10) Rabbit (4)
Reactivity:	Human (14) Rat (7) Mouse (10) Rabbit (2) Zebrafish (1)
Application:	IHC-P (10) ICC/IF (7) IF-Tissue (1) IP (2) WB (8) FC (8) ELISA (1)
Isotype:	IgG (5) IgG1 (5) IgG2a (3)
Conjugation:	Non-conjugated (14)
Clonality:	Monoclonal (10) Recombinant (3)
Modification:	Unmodified (10)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P82930

	AKR1C1/AKR1C2 Antibody (YA2675) AKR1C1; AKR1C2	WB, FC	Human, Mouse, Rat
	AKR1C1/AKR1C2 Antibody (YA2675) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AKR1C1/AKR1C2.

HY-P81368

	AKR1B10 Antibody (YA1113) AKR1B10; AKR1B11; Aldo-keto reductase family 1 member B10; ARL-1; Aldose reductase-like; Aldose reductase-related protein (ARP; hARP); Small intestine reductase (SI reductase)	IHC-P	Human
	AKR1B10 Antibody (YA1113) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AKR1B10.

HY-P81368A

	AKR1B10 Antibody (YA1113)(PBS only) AKR1B10; AKR1B11; Aldo-keto reductase family 1 member B10; ARL-1; Aldose reductase-like; Aldose reductase-related protein (ARP; hARP); Small intestine reductase (SI reductase)	IHC-P	Human
	AKR1B10 Antibody (YA1113) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AKR1B10.

HY-P88496

	AKR1A1 Antibody (YA8180) ALDR1; ALR; ARM; DD3; HEL-S-6	IHC-P, ICC/IF, FC	Human, Mouse, Rat
	AKR1A1 Antibody (YA8180) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to AKR1A1.

HY-P88496A

	AKR1A1 Antibody (YA8180)(PBS only) ALDR1; ALR; ARM; DD3; HEL-S-6	IHC-P, ICC/IF, FC	Human, Mouse, Rat
	AKR1A1 Antibody (YA8180) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to AKR1A1.

HY-P85558

	Aldose Reductase Antibody (YA5250) ADR; AKR1B 1; AKR1b1; Aldehyde reductase 1; Aldehyde reductase; Aldo keto reductase family 1, member B1; Aldo-keto reductase family 1 member B1; aldo-keto reductase family 1, member B1; aldose reductase; Aldose reductase; aldr 1; ALDR_HUMAN; ALDR1; ALR2; AR; Lii5 2 CTCL tumor antigen; Low Km aldose reductase; MGC1804.	WB	Human, Mouse, Rat
	Aldose Reductase Antibody (YA5250) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Aldose Reductase.

HY-P82593

	AKR1C3 Antibody (YA2338) DD3; DDX; HA1753; HAKRB; HAKRe; HSD17B5; KIAA0119; hluPGFS	WB, ICC/IF, IP, FC	Human
	AKR1C3 Antibody (YA2338) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AKR1C3.

HY-P85418

	Aldose Reductase Antibody (YA5110) AKR1B1; ALDR1; Aldose reductase; AR; Aldehyde reductase; Aldo-keto reductase family 1 member B1	WB, ICC/IF, IP, ELISA, IF-Tissue	Human, Mouse, Rat
	Aldose Reductase Antibody (YA5110) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Aldose Reductase.

HY-P88678

	KCNAB1 (Kv beta 1) Antibody (YA8362) AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1; Kvb1.3	IHC-P, ICC/IF, FC	Human, Mouse, Rat
	KCNAB1 (Kv beta 1) Antibody (YA8362) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KCNAB1 (Kv beta 1).

HY-P88678A

	KCNAB1 (Kv beta 1) Antibody (YA8362)(PBS only) AKR6A3; hKvb3; hKvBeta3; KCNA1B; KV-BETA-1; Kvb1.3	IHC-P, ICC/IF, FC	Human, Mouse, Rat
	KCNAB1 (Kv beta 1) Antibody (YA8362) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to KCNAB1 (Kv beta 1).

HY-P84483

	AKR1C1 Antibody (YA4180) C9; DD1; DDH; DDH1; H-37; HBAB; MBAB; HAKRC; DD1/DD2; 2-ALPHA-HSD; 20-ALPHA-HSD	WB, IHC-P, FC	Human, Mouse, Rabbit
	AKR1C1 Antibody (YA4180) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AKR1C1.

HY-P87505

	AKR1C1 Antibody (YA7189) C9; DD1; DDH; DDH1; H-37; HBAB; MBAB; HAKRC; DD1/DD2; 2-ALPHA-HSD; 20-ALPHA-HSD	WB, IHC-P	Human, Mouse
	AKR1C1 Antibody (YA7189) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to AKR1C1.

HY-P84483A

	AKR1C1 Antibody (YA4180)(PBS only) C9; DD1; DDH; DDH1; H-37; HBAB; MBAB; HAKRC; DD1/DD2; 2-ALPHA-HSD; 20-ALPHA-HSD	WB, IHC-P, FC	Human, Mouse, Rabbit
	AKR1C1 Antibody (YA4180) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AKR1C1.

HY-P87365

	AKR7A2 Antibody (YA7048) AFAR antibody; AFAR1 antibody; AFB1 aldehyde reductase 1 antibody; AFB1 AR1 antibody; AFB1-AR 1 antibody; AFB1AR1 antibody; Aflatoxin aldehyde reductase antibody; Aflatoxin B1 aldehyde reductase member 2 antibody; Aflatoxin beta1 aldehyde reductase antibody; Aiar antibody	WB, ICC/IF, IHC-P	Human, Zebrafish
	AKR7A2 Antibody (YA7048) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to AKR7A2.