KARS-IN-1
KARS-IN-1 (152) is a AKR1C3 dependent KARS inhibitor with an AC50 of 9.1 nM for human KARS. KARS-IN-1 shows anti-proliferative activity in H460 (NRF2 pathway mutant cell line with high AKR1C3 expression) and Hara (NRF2 pathway wild type cell line with low AKR1C3 expression), with AC50 values ??of 21 nM and 16 nM, respectively. KARS-IN-1 can be used for the study of non-small cell lung cancer (NSCLC).
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- No. CAS: 2579083-99-9
- Fòrmula: C21H23F2N3O2
- Peso molecular:387.42
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Chemical Information
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No. CAS 2579083-99-9
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Peso molecular 387.42
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Fòrmula C21H23F2N3O2
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SMILES
FC(C=C1)=CC=C1CNC(N(CC2)CCC32C[C@@H](O)C4=CC(F)=CC=C4N3)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KARS-IN-1 Related Classifications
HY-180562 Related Classifications
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