Aldose Reductase Antibody (YA5250)
(Synonyms: ADR; AKR1B 1; Akr1b1; Aldehyde reductase 1; Aldehyde reductase; Aldo keto reductase family 1, member B1; Aldo-keto reductase family 1 member B1; aldo-keto reductase family 1, member B1; aldose reductase; Aldose reductase; aldr 1; ALDR_HUMAN; ALDR1; ALR2; AR; Lii5 2 CTCL tumor antigen; Low Km aldose reductase; MGC1804.)Aldose Reductase Antibody (YA5250) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Aldose Reductase.
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Host:
Mouse
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Application:
WB
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:1000 |
Product Details
Aldose Reductase Antibody (YA5250) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Aldose Reductase.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 36 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
Purified recombinant human AKR1B1 protein fragments expressed in E.coli.
affinity chromatography.
Non-conjugated
Unmodified
Product Properties
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Appearance
Solution
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Formulation
Supplied in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Aldose reductase is a small, cytosolic, monomeric enzyme which belongs to the aldo-keto reductase superfamily. Aldose reductase catalyzes the reduced form of nicotinamide adenine dinucleotide phosphate (NADPH) -dependent reduction of a wide variety of aromatic and aliphatic carbonyl compounds. It is implicated in the development of diabetic and galactosemic complications involving the lens, retina, nerves, and kidney.
Aldose reductase is both the key enzyme of the polyol pathway, whose activation under hyperglycemic conditions leads to the development of chronic diabetic complications, and the crucial promoter of inflammatory and cytotoxic conditions, even under a normoglycemic status. Aldose reductase represents an excellent drug target and a huge effort is being done to disclose novel compounds able to inhibit it.
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Subcellular Localization
Cytoplasm
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Expression
Tissue_specificity:Under osmotic stress, this gene is highly expressed in embryonic epithelial cells (EUE) . -
Subunit
Monomer
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SwissProt ID
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Synonyms
ADR; AKR1B 1; Akr1b1; Aldehyde reductase 1; Aldehyde reductase; Aldo keto reductase family 1, member B1; Aldo-keto reductase family 1 member B1; aldo-keto reductase family 1, member B1; aldose reductase; Aldose reductase; aldr 1; ALDR_HUMAN; ALDR1; ALR2; AR; Lii5 2 CTCL tumor antigen; Low Km aldose reductase; MGC1804.
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