Akr1b1 - aldo-keto reductase family 1 member B1 Gene

Also Known as Alr; Aldr1; ALDRED; Akr1b3; Akr1b4; ALR-P-I; RATALDRED

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 24192

Summary

Enables alditol:NADP+ 1-oxidoreductase activity and cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity. Involved in several processes, including inner medullary collecting duct development; positive regulation of receptor signaling pathway via JAK-STAT; and sorbitol biosynthetic process. Located in several cellular components, including Schmidt-Lanterman incisure; Schwann cell microvillus; and mast cell granule. Used to study allergic disease; cataract; diabetic neuropathy; and diabetic retinopathy. Biomarker of diabetic retinopathy; galactosemia; hepatocellular carcinoma; hyperglycemia; and hypokalemia. Human ortholog(s) of this gene implicated in arteriosclerosis; cataract; diabetic neuropathy; diabetic retinopathy; and type 2 diabetes mellitus. Orthologous to human AKR1B1 (aldo-keto reductase family 1 member B). [provided by Alliance of Genome Resources, Apr 2022]

Akr1b1 Products (1)

mRNA Protein Name
NM_012498.1 NP_036630.1 aldo-keto reductase family 1 member B1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aldose reductase (NADPH) activity IDA
IDA: Inferred from direct assay
2114645 RGD
enables cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity IDA
IDA: Inferred from direct assay
8407226 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to methylglyoxal IDA
IDA: Inferred from direct assay
12604218 RGD
involved in cellular response to peptide IEP
IEP: Inferred from expression pattern
17490626 RGD
involved in inner medullary collecting duct development IDA
IDA: Inferred from direct assay
1401064 RGD
involved in maternal process involved in female pregnancy IEP
IEP: Inferred from expression pattern
2121099 RGD
involved in monosaccharide metabolic process IDA
IDA: Inferred from direct assay
2119895 RGD
involved in norepinephrine metabolic process IDA
IDA: Inferred from direct assay
10424772 RGD
involved in positive regulation of receptor signaling pathway via JAK-STAT IMP
IMP: Inferred from mutant phenotype
15746188 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
16648138 RGD
involved in response to thyroid hormone IEP
IEP: Inferred from expression pattern
19422879 RGD
involved in sorbitol biosynthetic process IMP
IMP: Inferred from mutant phenotype
6690344 RGD
involved in stress-activated protein kinase signaling cascade IMP
IMP: Inferred from mutant phenotype
16669970 RGD
involved in tissue homeostasis IMP
IMP: Inferred from mutant phenotype
21376710 RGD
Cellular Component GO Annotation Evidence References Source
located in Schmidt-Lanterman incisure IDA
IDA: Inferred from direct assay
1650113 RGD
located in Schwann cell microvillus IDA
IDA: Inferred from direct assay
1650113 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
16332428 RGD
located in mast cell granule IDA
IDA: Inferred from direct assay
1650113 RGD
located in paranodal junction IDA
IDA: Inferred from direct assay
1650113 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
8150024 RGD
located in plasma membrane bounded cell projection cytoplasm IDA
IDA: Inferred from direct assay
8150024 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

aldo-keto reductase family 1 member B1

  • AR

  • Aldehyde reductase 1 (low Km aldose reductase) (5.8 kb PstI fragment, probably the functional gene)

  • aldo-keto reductase family 1 member B

  • aldose reductase

Akr1b1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P85558 Aldose Reductase Antibody (YA5250) WB Human, Mouse, Rat

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-106697 Ponalrestat Inhibitor 99.51% Phase 3

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-133708 β-Glucogallin 99.82% Unkown
HY-N0310 Soyasaponin Bb 99.88% Unkown
HY-N0412 Sesamoside Inhibitor 99.77% Unkown
HY-RS00532 AKR1B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17235 Akr1b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-177415 JSD26 Inhibitor / Unkown
HY-149254 PTP1B/AKR1B1-IN-1 Inhibitor / Unkown
HY-149255 PTP1B/AKR1B1-IN-2 Inhibitor / Unkown
HY-175331 ALR2-IN-7 Inhibitor 99.94% Unkown
HY-175639 ALR2-IN-8 Inhibitor / Unkown
HY-176719 AKR1B1/STAT3/SLC7A11-regulator-1 / Unkown
HY-RS23688 Akr1b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Akr1b1 NCBI NCBI:231