AKR1B1 - aldo-keto reductase family 1 member B Gene

Also Known as AR; ADR; ALR2; ALDR1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 231

About AKR1B1

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:134,442,350-134,459,239 (from NCBI)

This gene has 14 transcripts (splice variants), 395 orthologues and 16 paralogues. Biased expression in adrenal (RPKM 1087.3), placenta (RPKM 120.6) and 2 other tissues.

Summary

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known Enzymes and proteins. This member catalyzes the reduction of a number of aldehydes, including the aldehyde form of glucose, and is thereby implicated in the development of diabetic complications by catalyzing the reduction of glucose to sorbitol. Multiple pseudogenes have been identified for this gene. The nomenclature system used by the HUGO Gene Nomenclature Committee to define human aldo-keto reductase family members is known to differ from that used by the Mouse Genome Informatics database. [provided by RefSeq, Feb 2009]

AKR1B1 Products (2)

mRNA	Protein	Name
NM_001346142.1	NP_001333071.1	aldo-keto reductase family 1 member B1 isoform 2
NM_001628.4	NP_001619.1	aldo-keto reductase family 1 member B1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables aldose reductase (NADPH) activity	EXP EXP: Inferred from Experiment	1420136	GOA
enables aldose reductase (NADPH) activity	IDA IDA: Inferred from direct assay	8435445	GOA
enables glyceraldehyde oxidoreductase activity	IDA IDA: Inferred from direct assay	20837989	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables retinal dehydrogenase activity	IDA IDA: Inferred from direct assay	12732097	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cellular hyperosmotic salinity response	IDA IDA: Inferred from direct assay	8435445	GOA
involved in daunorubicin metabolic process	IMP IMP: Inferred from mutant phenotype	20837989	GOA
involved in doxorubicin metabolic process	IMP IMP: Inferred from mutant phenotype	20837989	GOA
involved in retinoid metabolic process	IMP IMP: Inferred from mutant phenotype	12732097	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AKR1B1 Protein Structure

Aldo_ket_red

0
100
200
300
316 a.a.

Protein Preferred Names	Protein Names
aldo-keto reductase family 1 member B1	Lii5-2 CTCL tumor antigen

AKR1B1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	AKR1B1	P15121	EFCAB11	Homo sapiens	Q9BUY7	Y2H Array	32296183
Intra	AKR1B1	P15121	EFCAB11	Homo sapiens	Q9BUY7	Y2H Prey Pooling	32296183
Intra	AKR1B1	P15121	EFCAB11	Homo sapiens	Q9BUY7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AKR1B1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75521	AKR1B1 Protein, Human (His)	P15121 (M1-F316)	≥ 95%, as determined by reducing SDS-PAGE.

AKR1B1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81338	Aldose Reductase Antibody (YA1083)	WB	Human, Mouse, Rat
HY-P81338A	Aldose Reductase Antibody (YA1083)(PBS only)	WB	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Diabetic Neuropathy	Diabetic Neuropathies
Diabetic Cataract	Cataract - Diabetic
Diabetic Autonomic Neuropathy	Diabetic Neuropathies
Diabetic Polyneuropathy	Diabetes Mellitus With Polyneuropathy Polyneuropathy In Diabetes Diabetic Polyneuropathies Diabetic Neuropathy Nos
Hyperglycemia
Galactosemia I	Galactosemia Galt Deficiency Classic Galactosemia Galactose-1-Phosphate Uridylyltransferase Deficiency Galactose-1-Phosphate Uridyltransferase Deficiency GALAC1 Galactosemia, Classic Galactosemia Type 1 Galactosemias Classical Galactosemia Galactosaemia Galactose Intolerance Epimerase Deficiency Galactosemia Galactokinase Deficiency Disease Galactose Epimerase Deficiency Galactose-1-Phosphate Uridyl-Transferase Deficiency Disease Gale Deficiency Galk Deficiency Udp-Galactose-4-Epimerase Deficiency Disease Utp Hexose-1-Phosphate Uridylyltransferase Deficiency Galactosemia 1 Galactosemia, Duarte Variant Deficiency Of Galactokinase Udpglucose 4-Epimerase Deficiency Disease Classical Galactosaemia Galput Deficiency - [Galactose-4-Phosphate Uridyltransferase] Deficiency Classic Galactosaemia Deficiency Of Hexose-1-Phosphate Uridylyltransferase Deficiency Of Udpglucose-Hexose-1-Phosphate Uridylyltransferase Deficiency Of Galactose-1-Phosphate Uridylyltransferase Galactose-1-Phosphate Uridyl Transferase Deficiency Transferase Deficiency Galactosemia Deficiency Of Uridyl Transferase Deficiency Of Utp-Hexose-1-Phosphate Uridylyltransferase Utp-Hexose-1-Phosphate Uridyltransferase Deficiency
Autonomic Neuropathy	Diabetic Autonomic Neuropathy
Microvascular Complications Of Diabetes 5	Diabetic Retinopathy Microvascular Complications Of Diabetes, Susceptibility To, 5 MVCD5 Retinopathy, Diabetic Diabetic Nephropathy Retinopathy, Diabetic, Susceptibility To Retinal Abnormality - Diabetes-Related
Retinal Vascular Disease	Retinal Vascular Retinal Vascular Disorder Retina Circulation Disorder
Polyneuropathy	Polyneuropathies
Type 1 Diabetes Mellitus	Diabetes Mellitus, Insulin-Dependent Diabetes Mellitus Type 1 IDDM Type 1 Diabetes Insulin-Dependent Diabetes Mellitus T1D Juvenile-Onset Diabetes Jod Diabetes Mellitus, Type 1 Diabetes Mellitus, Insulin-Dependent-1 Type I Diabetes Mellitus Autoimmune Diabetes Juvenile Diabetes Juvenile-Onset Diabetes Mellitus Diabetes, Insulin Dependent Insulin-Dependent Diabetes Mellitus-1 Diabetes Mellitus Insulin-Dependent Diabetes Autoimmune Diabetes Mellitus, Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 1, Susceptibility To Diabetes Type 1 Type I Diabetes Diabetes, Autoimmune T1dm - [Type 1 Diabetes Mellitus] Iddm - [Insulin Dependent Diabetes Mellitus] Type 1 Iddm Juvenile Diabetes Mellitus Without Compications Idiopathic Insulin-Dependent Diabetes Mellitus Without Complications Juvenile-Onset Diabetes Mellitus Without Compications Ketosis-Prone Diabetes Mellitus Without Compications Juvenile-Onset-Type Diabetes Mellitus Without Compications
Mature Cataract	Total Or Mature Cataract Total, Mature Senile Cataract
Cataract	Cataracts Cat - [Cataract] Cataract Form Lens Opacity Lens Opacities
Lens Disease	Lens Diseases
Diabetes Mellitus	Diabetes
Kidney Disease	Renal Failure Kidney Failure Kidney Diseases Nephropathy Abnormality Of The Kidney Impaired Renal Function Disease Renal Anomaly Kidney Dysfunction Renal Disease Nephropathies Renal Failure Adverse Event Abnormal Renal Function
Microvascular Complications Of Diabetes 3	Diabetic Nephropathy Microvascular Complications Of Diabetes, Susceptibility To, 3 MVCD3 Nephropathy, Diabetic Nephropathy, Diabetic, Susceptibility To End-Stage Renal Disease, Diabetic End-Stage Renal Disease, Diabetic, Susceptibility To Diabetic End-Stage Renal Disease Diabetic Nephropathies
Sensory Peripheral Neuropathy	Sensory Neuropathy Peripheral Sensory Neuropathy Hereditary Sensory And Autonomic Neuropathies
Retinal Microaneurysm	Microaneurysm
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Background Diabetic Retinopathy	Non Proliferative Diabetic Retinopathy Non-Proliferative Diabetic Retinopathy Nonproliferative Diabetic Retinopathy
Hypoglycemia	Hypoglycaemia Low Blood Sugar Hypoglycaemia Nos Spontaneous Hypoglycaemia Nondiabetic Hypoglycaemia Hypoglycaemic Disorder Nos Hypoglycaemic Syndrome
Corneal Disease	Corneal Diseases Corneal Disorders
Severe Nonproliferative Diabetic Retinopathy	High Risk Non Proliferative Diabetic Retinopathy Severe Npdr
Recurrent Corneal Erosion	Recurrent Erosion Of Cornea Recurrent Erosion Syndrome Corneal Erosion Non-Traumatic Recurrent Erosion Of Cornea
Retinal Degeneration	Degeneration Of Retina
Constipation
Keratopathy
Senile Cataract
American Histoplasmosis	Infection By Histoplasma Capsulatum
Autonomic Nervous System Disease	Autonomic Nervous System Dysfunction Autonomic Nervous System Disorders Autonomic Nervous System Disorder Autonomic Nervous System Diseases Abnormality Of The Autonomic Nervous System
Diabetic Macular Edema
Macular Retinal Edema	Macular Edema Macular Oedema Macular Retinal Oedema Macular Edema, Cystoid
Transient Refractive Change
Peripheral Nervous System Disease	Peripheral Neuropathy Peripheral Nerve Disease Peripheral Nerve Disorders Neuropathy, Peripheral Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Eye Disease	Eye Diseases Abnormality Of The Eye Toxoplasma Oculopathy
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-106697	Ponalrestat	Inhibitor	99.51%	Phase 3

Pre-clinical Phase

Bioactive Molecules (12)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-133708	β-Glucogallin		99.82%	Unkown
HY-N0310	Soyasaponin Bb		99.88%	Unkown
HY-N0412	Sesamoside	Inhibitor	99.77%	Unkown
HY-RS00532	AKR1B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17235	Akr1b1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-177415	JSD26	Inhibitor	/	Unkown
HY-149254	PTP1B/AKR1B1-IN-1	Inhibitor	/	Unkown
HY-149255	PTP1B/AKR1B1-IN-2	Inhibitor	/	Unkown
HY-175331	ALR2-IN-7	Inhibitor	99.94%	Unkown
HY-175639	ALR2-IN-8	Inhibitor	/	Unkown
HY-176719	AKR1B1/STAT3/SLC7A11-regulator-1		/	Unkown
HY-RS23688	Akr1b1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	AKR1B1	VGNC	VGNC:59724
Macaca mulatta	AKR1B1	VGNC	VGNC:108391
Mus musculus	AKR1B1	MGD	MGI:1353494
Rattus norvegicus	AKR1B1	RGD	RGD:2092
Others	AKR1B1	NCBI