Adhumulone
Adhumulone is an α-acid derived from hops and a selective AKR1B10 inhibitor, with IC50 values of 5.41-29.27 μM and Ki values of 3.27-16.79 μM against human AKR1B10. Adhumulone inhibits AKR1B10-mediated reduction of Farnesol (HY-Y0248A) as a competitive inhibitor, and it also suppresses the reduction of DL-Glyceraldehyde (HY-128748) and Farnesal substrates. Adhumulone is useful for research on ras-dependent malignancies.
For research use only. We do not sell to patients.
- CAS No.: 31769-65-0
- Formula: C21H30O5
- Molecular Weight:362.46
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
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AKR1B10 5.41-29.27 μM (IC50) |
AKR1B10 3.27-16.79 μM (Ki) |
In Vitro
Adhumulone (Compound 1) selectively inhibits recombinant human AKR1B10 when DL-Glyceraldehyde (HY-128748) is used as the substrate, with an IC50 of 5.41 µM and a Ki value of 3.27 μM, while its activity against AKR1A1 and AKR1B1 is much weaker[1].
Adhumulone acts as a competitive inhibitor of recombinant human AKR1B10-mediated reduction of Farnesol (HY-Y0248A), with an IC50 of 29.27 µM and a Ki of 16.79 µM[1].
Adhumulone (41c) is a major α-acid sensory metabolite in fresh Humulus lupulus L. hop pellets, with concentrations ranging from 5-15% across 75 commercial hop varieties[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 31769-65-0
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Molecular Weight 362.46
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Formula C21H30O5
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SMILES
O=C(C(CC)C)C(C(O)=C1C/C=C(C)\C)=C(O)C(O)(C/C=C(C)\C)C1=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Adhumulone Related Classifications
HY-N21682 Related Classifications
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