31769-65-0
31769-65-0
Chemical Structure
Adhumulone
- CAS No.: 31769-65-0
- Formula:C21H30O5
- Molecular Weight:362.46
InChIKey: QLDKPODPJVFMAW-UHFFFAOYSA-N
SMILES: O=C(C(CC)C)C(C(O)=C1C/C=C(C)\C)=C(O)C(O)(C/C=C(C)\C)C1=O
Biological Activity: Adhumulone is an α-acid derived from hops and a selective AKR1B10 inhibitor, with IC50 values of 5.41-29.27 μM and Ki values of 3.27-16.79 μM against human AKR1B10. Adhumulone inhibits AKR1B10-mediated reduction of Farnesol (HY-Y0248A) as a competitive inhibitor, and it also suppresses the reduction of DL-Glyceraldehyde (HY-128748) and Farnesal substrates. Adhumulone is useful for research on ras-dependent malignancies[1][2].
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Adhumulone | Adhumulone is an α-acid derived from hops and a selective AKR1B10 inhibitor, with IC50 values of 5.41-29.27 μM and Ki values of 3.27-16.79 μM against human AKR1B10. Adhumulone inhibits AKR1B10-mediated reduction of Farnesol (HY-Y0248A) as a competitive inhibitor, and it also suppresses the reduction of DL-Glyceraldehyde (HY-128748) and Farnesal substrates. Adhumulone is useful for research on ras-dependent malignancies. | |||||||||||||||||||||
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References
- [1]. Seliger JM, et al. Selective Inhibition of Human AKR1B10 by n-Humulone, Adhumulone and Cohumulone Isolated from Humulus lupulus Extract. Molecules. 2018 Nov 21;23(11):3041.
- [2]. Dresel M, et al. The Bitter Chemodiversity of Hops (Humulus lupulus L.). Journal of agricultural and food chemistry. 2016;64(41):7789-7799. [Content Brief]
