2. Metabolic Enzyme/Protease
  3. Aldose Reductase
  4. JSD26

JSD26 is a selective and orally active SCoR2 (AKR1A1) inhibitor with an IC50 of 93 nM. JSD26 has 10-fold selectivity for SCoR2 versus AKR1B1. JSD26 can be used for the study acute kidney injury (AKI).

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JSD26

JSD26 Chemical Structure

CAS No. : 2353515-08-7

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Description

JSD26 is a selective and orally active SCoR2 (AKR1A1) inhibitor with an IC50 of 93 nM. JSD26 has 10-fold selectivity for SCoR2 versus AKR1B1. JSD26 can be used for the study acute kidney injury (AKI)[1].

IC50 & Target

SCoR2

93 nM (IC50)

In Vivo

JSD26 (20-120 mg/kg, i.p., once) inhibits SCoR2 in mice without affecting AKR1B1[1].
JSD26 (120 mg/kg, i.p., once) alleviates symptoms in acute kidney injury (AKI) mice by selectively inhibiting SCoR2 and increasing S-nitrosylation of PKM2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Healthy C57BL/6J mice[1].
Dosage: 20 mg/kg, 40 mg/kg, 80 mg/kg, 120 mg/kg
Administration: I.p., once
Result: At the highest dose (120 mg/kg), renal SCoR2 activity was inhibited by 80%.
Did not inhibit renal AKR1B1 activity and inhibited SCoR2 in other organs (liver, lung, heart, spleen), but showed no inhibition in brain tissue, indicating that it cannot cross the blood-brain barrier.
Animal Model: Male C57BL/6J (9–11 weeks, 25–28 g) were induced with AKI via ischemia-reperfusion (I/R) surgery[1].
Dosage: 120 mg/kg
Administration: I.p., once
Result: Renal SCoR2 activity was inhibited by 80%, but SCoR2 protein expression levels remained unchanged.
Serious creatinine and BUN levels were significantly reduced, indicating improved renal function.
Histological analysis (H&E staining) showed reduced tubular damage in the JSD26 treatment group (e.g., reduced tubular dissolution and debris).
PKM2 S-nitrosylation (SNO-PKM2) levels were increased, and PKM2 activity was decreased.
Molecular Weight

290.32

Formula

C18H14N2O2
CAS No.
SMILES

O=C1NC(C2(C3=C(C4=CC=C(C5CC5)C=C42)C=CC=C3)N1)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JSD26 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JSD262353515-08-7JSD 26JSD-26Aldose ReductaseAcute Kidney InjuryAKISCoR2 InhibitorAKR1A1PKM2Inhibitorinhibitorinhibit

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