JSD26
Based on 1 Customer Validation
JSD26 is a selective and orally active SCoR2 (AKR1A1) inhibitor with an IC50 of 93 nM. JSD26 has 10-fold selectivity for SCoR2 versus AKR1B1. JSD26 can be used for the study acute kidney injury (AKI).
For research use only. We do not sell to patients.
- Purity : 98.32%
- CAS No.: 2353515-08-7
- Formula: C18H14N2O2
- Molecular Weight:290.32
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
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SCoR2 93 nM (IC50) |
In Vivo
JSD26 (120 mg/kg, i.p., once) alleviates symptoms in acute kidney injury (AKI) mice by selectively inhibiting SCoR2 and increasing S-nitrosylation of PKM2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Healthy C57BL/6J mice[1].
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Dosage:20 mg/kg, 40 mg/kg, 80 mg/kg, 120 mg/kg
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Administration:I.p., once
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Result:At the highest dose (120 mg/kg), renal SCoR2 activity was inhibited by 80%.
Did not inhibit renal AKR1B1 activity and inhibited SCoR2 in other organs (liver, lung, heart, spleen), but showed no inhibition in brain tissue, indicating that it cannot cross the blood-brain barrier.
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Animal Model:Male C57BL/6J (9–11 weeks, 25–28 g) were induced with AKI via ischemia-reperfusion (I/R) surgery[1].
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Dosage:120 mg/kg
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Administration:I.p., once
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Result:Renal SCoR2 activity was inhibited by 80%, but SCoR2 protein expression levels remained unchanged.
Serious creatinine and BUN levels were significantly reduced, indicating improved renal function.
Histological analysis (H&E staining) showed reduced tubular damage in the JSD26 treatment group (e.g., reduced tubular dissolution and debris).
PKM2 S-nitrosylation (SNO-PKM2) levels were increased, and PKM2 activity was decreased.
Chemical Information
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CAS No. 2353515-08-7
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Appearance Solid
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Molecular Weight 290.32
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Formula C18H14N2O2
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Color White to off-white
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SMILES
O=C1NC(C2(C3=C(C4=CC=C(C5CC5)C=C42)C=CC=C3)N1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
In Vitro:
DMSO : 100 mg/mL (344.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (281 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.4445 mL | 17.2224 mL | 34.4447 mL | 86.1119 mL |
| 5 mM | 0.6889 mL | 3.4445 mL | 6.8889 mL | 17.2224 mL | |
| 10 mM | 0.3444 mL | 1.7222 mL | 3.4445 mL | 8.6112 mL | |
| 15 mM | 0.2296 mL | 1.1482 mL | 2.2963 mL | 5.7408 mL | |
| 20 mM | 0.1722 mL | 0.8611 mL | 1.7222 mL | 4.3056 mL | |
| 25 mM | 0.1378 mL | 0.6889 mL | 1.3778 mL | 3.4445 mL | |
| 30 mM | 0.1148 mL | 0.5741 mL | 1.1482 mL | 2.8704 mL | |
| 40 mM | 0.0861 mL | 0.4306 mL | 0.8611 mL | 2.1528 mL | |
| 50 mM | 0.0689 mL | 0.3444 mL | 0.6889 mL | 1.7222 mL | |
| 60 mM | 0.0574 mL | 0.2870 mL | 0.5741 mL | 1.4352 mL | |
| 80 mM | 0.0431 mL | 0.2153 mL | 0.4306 mL | 1.0764 mL | |
| 100 mM | 0.0344 mL | 0.1722 mL | 0.3444 mL | 0.8611 mL |
JSD26 Related Classifications
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