Avatrombopag maleate (Standard)
Avatrombopag (maleate) (Standard) is the analytical standard of Avatrombopag (maleate). This product is intended for research and analytical applications. Avatrombopag maleate (AKR-501) is an orally active, nonpeptide thrombopoietin (TPO) receptor agonist (EC50=3.3 nM). Avatrombopag maleate mimics the biological activities of TPO. Avatrombopag maleate increases platelet production by activating the intracellular signaling system, and promotes production of platelets and megakaryocytes from hemopoietic precursor cells. Avatrombopag maleate is a substrate of cytochrome P450 (CYP) 2C9 and CYP3A.
For research use only. We do not sell to patients.
- Purity: 98%
- CAS No.: 677007-74-8
- Formula: C33H38Cl2N6O7S2
- Molecular Weight:765.73
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
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HY-13463A
Avatrombopag maleate
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HY-15306
Eltrombopag
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HY-13463
Avatrombopag
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HY-15306A
Eltrombopag Olamine
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HY-19883
Lusutrombopag
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HY-P990685
Romiplostim
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HY-13463B
Avatrombopag hydrochloride
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HY-13463R
Avatrombopag (Standard)
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HY-122620
Rafutrombopag (tautomerism)
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HY-15306R
Eltrombopag (Standard)
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HY-19883R
Lusutrombopag (Standard)
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HY-15306AR
Eltrombopag Olamine (Standard)
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 677007-74-8
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Molecular Weight 765.73
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Formula C33H38Cl2N6O7S2
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SMILES
O=C(C1CCN(C2=NC=C(C(NC3=NC(C4=CC(Cl)=CS4)=C(N5CCN(C6CCCCC6)CC5)S3)=O)C=C2Cl)CC1)O.O=C(O)/C=C\C(O)=O
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Synonyms
AKR-501 maleate (Standard); E5501 maleate (Standard); YM477 maleate (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Fukushima-Shintani M, et al. AKR-501 (YM477) a novel orally-active thrombopoietin receptor agonist. Eur J Haematol. 2009;82(4):247-254. [Content Brief]
[2]. Xu H, et al. Avatrombopag for the treatment of thrombocytopenia in patients with chronic liver disease. Expert Rev Clin Pharmacol. 2019;12(9):859-865. [Content Brief]
[3]. Nomoto M, Zamora CA, Schuck E, et al. Pharmacokinetic/pharmacodynamic drug-drug interactions of avatrombopag when coadministered with dual or selective CYP2C9 and CYP3A interacting drugs. Br J Clin Pharmacol. 2018;84(5):952-960. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Avatrombopag maleate (Standard) Related Classifications
HY-13463AR Related Classifications
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