AKR1B10 Antibody (YA1113)(PBS only)

Cat. No.: HY-P81368A: Ficha de datos User Guide for Antibodies
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AKR1B10 Antibody (YA1113) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AKR1B10.

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Tamaño		Stock
50 μL		Obtener un presupuesto
100 μL		Obtener un presupuesto

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Descripciòn

Descripciòn

AKR1B10 Antibody (YA1113) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to AKR1B10.

Host

Rabbit

Peso molecular

Predicted band size: 36 kDa;

Observed band size: 36 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

O60218

Gene ID

57016 [NCBI]

Immunogen

A synthesized peptide derived from human AKR1B10

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-1:200

Pureza	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Envío

Shipping with blue ice.

Background

Function：Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols (PubMed:12732097, PubMed:18087047, PubMed:19013440, PubMed:19563777, PubMed:9565553). Displays strong enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal (PubMed:12732097, PubMed:18087047). Plays a critical role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls) (PubMed:19013440, PubMed:19563777). Displays no reductase activity towards glucose (PubMed:12732097)

Subcellular Localization：Lysosome; Secreted

Expression：
Tissue_specificity:Found in many tissues. Highly expressed in small intestine, colon and adrenal gland

Induction:Overexpressed in certain types of cancers, including hepatocellular carcinoma and lung cancer associated with tobacco smoking

Research Field

Signal Transduction

Synonyms

AKR1B10; AKR1B11; Aldo-keto reductase family 1 member B10; ARL-1; Aldose reductase-like; Aldose reductase-related protein (ARP; hARP); Small intestine reductase (SI reductase)

Documentación

User Guide for Antibodies (1077 KB)