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Pathways Recommended:	Antibody-drug Conjugate/ADC Related

Results for "

CRBN ligand-Linker Conjugate

" in MedChemExpress (MCE) Product Catalog:

By Targets:	E3 Ligase Ligand-Linker Conjugates (213) Target Protein Ligand-Linker Conjugates (9) Akt (2) Androgen Receptor (1) Apoptosis (10) Autophagy (6) Bcl-2 Family (1) Btk (2) c-Myc (3) CDK (3) Checkpoint Kinase (Chk) (1) E1/E2/E3 Enzyme (2) EGFR (1) Epigenetic Reader Domain (2) ERK (2) Estrogen Receptor/ERR (1) FGFR (1) FKBP (1) FLT3 (3) Fluorescent Dye (1) HDAC (2) HSP (2) JAK (1) MAP4K (1) Molecular Glues (1) PI3K (1) PROTACs (16) STAT (2)
By Research Areas:	Cancer (207) Infection (2) Inflammation/Immunology (5) Neurological Disease (1)
Click Chemistry:	Azide (6) Alkynes (2)
Oligonucleotides:	Pegylated Lipids (1)

239

Inhibitors & Agonists

Click Chemistry

Oligonucleotides

Targets Recommended: Target Protein Ligand-Linker Conjugates E3 Ligase Ligand-Linker Conjugates

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-175766

CRBN Ligand-Linker Conjugate 2	E3 Ligase Ligand-Linker Conjugates	Inflammation/Immunology
CRBN Ligand-Linker Conjugate 2 is a synthesized E3 ligand-linker conjugate that can be used for synthesis of PROTACs, such as FIP22 (HY-175764). FIP22 is a potent and selective IRAK4 PROTAC degrader with anti- atopic dermatitis activity .

HY-131875

Pomalidomide 4'-alkylC3-acid	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide 4'-alkylC3-acid is the E3 ligase ligand-linker conjugate used in the recruitment of CRBN protein. Pomalidomide 4'-alkylC3-acid can be used to synthesize PROTACs .

HY-160241

Lenalidomide-C5-acid	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-C5-acid is the Lenalidomide-based E3 ligase ligand-linker conjugate used in the recruitment of CRBN protein. Lenalidomide-C5-acid can be used to synthesize PROTACs .

HY-W594189

Desamino lenalidomide-Pip hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Desamino lenalidomide-Pip hydrochloride is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

HY-175545

CRBN ligand-Linker Conjugate 1	E3 Ligase Ligand-Linker Conjugates	Cancer
CRBN ligand-Linker Conjugate 1 is a CRBN ligand-linker conjugate that can be used for synthesis of TQ-3959 (HY-175541) .

HY-401504

Thalidomide-azetidine-COOH	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-azetidine-COOH is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

HY-W998240

Thalidomide-azetidine-C-OH	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-azetidine-C-OH is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

HY-W998259

Thalidomide-piperazine-C-COOH	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-piperazine-C-COOH is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

HY-W998301

Thalidomide-piperidin-C-piperidin hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-piperidin-C-piperidin hydrochloride is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

HY-W1120221

Lenalidomide-C3-NH2	E3 Ligase Ligand-Linker Conjugates	Others
Lenalidomide-C3-NH2 is an E3 ligase ligand-linker conjugate that incorporates the Lenalidomide (HY-A0003) based CRBN ligand (HY-43722) and linker. Lenalidomide-C3-NH2 can be used for synthesis of PROTAC BET degrader-2 (HY-114228) .

HY-174813

Pomalidomide-PEG3-Cys	E3 Ligase Ligand-Linker Conjugates	Others
Pomalidomide-PEG3-Cys is an E3 ligase ligand-linker conjugate that incorporates a CRBN ligand Pomalidomide (HY-10984) and 3-unit PEG linker. Pomalidomide-PEG3-Cys can be used for synthesis of PROTAC BRD4 Degrader-33 (HY-174811) .

HY-44148

FAK ligand-Linker Conjugate 1	Target Protein Ligand-Linker Conjugates	Cancer
FAK ligand-Linker Conjugate 1 incorporates a ligand for FAK, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). FAK ligand-Linker Conjugate 1 can be extensively used for PROTAC-mediated protein degradation .

HY-W998280

Thalidomide-propargyl-MeOH	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-propargyl-MeOH is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

HY-W998316

Thalidomide-piperazine-pyrrolidine dihydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-piperazine-pyrrolidine dihydrochloride is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

HY-W998273

Thalidomide-S-COOH	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-S-COOH is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

HY-W998272

Desamino lenalidomide-piperazine hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Desamino lenalidomide-piperazine hydrochloride is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

HY-W1115221

Desamino lenalidomide-azetidine-CHO	E3 Ligase Ligand-Linker Conjugates	Cancer
Desamino lenalidomide-azetidine-CHO is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

HY-W998260

Pomalidomide-cyclohexane-C-COOH	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide-cyclohexane-C-COOH is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

HY-W998302

Thalidomide-piperidin-O-piperidin	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-piperidin-O-piperidin is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

HY-W592697

Dihydrouracil-Ph-piperazine-Boc	E3 Ligase Ligand-Linker Conjugates	Cancer
Dihydrouracil-Ph-piperazine-Boc is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

HY-W1115217A

Desamino lenalidomide-Pip-azetidine hydrochloride	E3 Ligase Ligand-Linker Conjugates	Cancer
Desamino lenalidomide-Pip-azetidine hydrochloride is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

HY-W1115225

Desamino lenalidomide-piperidine-C-OH	E3 Ligase Ligand-Linker Conjugates	Cancer
Desamino lenalidomide-piperidine-C-OH is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

HY-139332

Pomalidomide 4'-PEG6-azide	E3 Ligase Ligand-Linker Conjugates	Cancer
Pomalidomide 4'-PEG6-azide (compound 33e) is the E3 ligase ligand-linker conjugate used in the recruitment of CRBN protein. Pomalidomide 4'-alkylC3-acid can be used to synthesize PROTACs .

HY-174797

Dione-piperidine-indazol-piperazin-cyclohexyl-NH2	E3 Ligase Ligand-Linker Conjugates	Others
Dione-piperidine-indazol-piperazin-cyclohexyl-NH2 is an E3 ligase ligand-linker conjugate that incorporates a CRBN ligand (HY-W883326) and linker. Dione-piperidine-indazol-piperazin-cyclohexyl-NH2 can be used for synthesis of PROTAC MD-4251 (HY-174458) .

HY-174880

CRBN ligand-8-O-C6-NH2	E3 Ligase Ligand-Linker Conjugates	Others
CRBN ligand-8-O-C6-NH2 is an E3 ligase ligand-linker conjugate that incorporates a CRBN ligand (HY-150831) and a linker. CRBN ligand-8-O-C6-NH2 can be used for synthesis of PROTAC ERα Degrader-11 (HY-174870) .

HY-176430

Lenalidomide-amide-pimelic acid	E3 Ligase Ligand-Linker Conjugates	Cancer
Lenalidomide-amide-pimelic acid is an E3 ligase ligand-linker conjugate that incorporates the Lenalidomide (HY-A0003) based CRBN ligand and Linker (HY-Y1139). Lenalidomide-amide-pimelic acid can be used for synthesis of PROTAC MNK1 degrader-1 (HY-176428) .

HY-174087

Thalidomide-4-OH-C11-OH	E3 Ligase Ligand-Linker Conjugates	Cancer
Thalidomide-4-OH-C11-OH is an E3 Ligase Ligand-Linker Conjugate, which is composed of Thalidomide-4-OH (HY-103596) and the corresponding Linker. Thalidomide-4-OH-C11-OH can be used as a Cereblon ligand to recruit CRBN protein and as a key intermediate for the synthesis of complete PROTACs molecules, such as PROTAC GPX4 degrader-4 (HY-174086) .

HY-176181

Thalidomide-4-PEG4-OTs	E3 Ligase Ligand-Linker Conjugates	Inflammation/Immunology
Thalidomide-4-OH-PEG4-OTs is an E3 ligase ligand-linker conjugate that incorporates the Thalidomide (HY-14658) based CRBN ligand (HY-103596) and 4-unit PEG linker (HY-176182). Thalidomide-4-OH-PEG4-OTs can be used for synthesis of PROTAC STING degrader-4 (HY-176180) .

HY-174869

Pomalidomide-5-C7-NH2	E3 Ligase Ligand-Linker Conjugates	Others
Pomalidomide-5-C7-NH2 is an E3 ligase ligand-linker conjugate that incorporates the 5-Aminothalidomide (HY-W023573) based CRBN ligand (HY-103596) and linker. Pomalidomide-5-C7-NH2 can be used for synthesis of PROTAC BT-O2C (HY-174866) .

HY-176425

E3 Ligase Ligand-linker Conjugate 186	E3 Ligase Ligand-Linker Conjugates	Inflammation/Immunology
E3 Ligase Ligand-linker Conjugate 186 is a CRBN E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 186 can be used to synthesize PROTAC SJ10542 (HY-145696) .

HY-172593

E3 Ligase Ligand-linker Conjugate 182	E3 Ligase Ligand-Linker Conjugates
E3 Ligase Ligand-linker Conjugate 182 is a E3 Ligase Ligand-Linker Conjugates. E3 Ligase Ligand-linker Conjugate 182 consists of a **CRBN ligand** and a PROTAC linker. E3 Ligase Ligand-linker Conjugate 182 can be used to design PROTACs (such as LZ-07 (HY-172590)) .

HY-172949

E3 Ligase Ligand-linker Conjugate 187	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 187 is a CRBN E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 187 can be used to synthesize PROTAC SD-2301 (HY-172946) .

HY-170673

E3 Ligase Ligand-linker Conjugate 156	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 156 is a CRBN E3 ligase ligand-linker conjugate. E3 Ligase Ligand-linker Conjugate 156 can be used to synthesize PROTAC XPO1 degrader-1 (HY-170669) .

HY-174796

E3 Ligase Ligand-linker Conjugate 195	E3 Ligase Ligand-Linker Conjugates	Inflammation/Immunology
E3 Ligase Ligand-linker Conjugate 195 is a conjugate of the CRBN ligand (HY-174470) and the linker. E3 Ligase Ligand-linker Conjugate 195 can be used for synthesis of PROTACs such as APH02174 (HY-174455) .

HY-163922

CRBN ligand-1-piperidine-Me	E3 Ligase Ligand-Linker Conjugates	Cancer
CRBN ligand-1-piperidine-Me is an E3 ligase ligand-linker conjugate.

HY-157756

E3 Ligase Ligand-linker Conjugate 104	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 104 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker* Conjugate 104 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162197

E3 ligase Ligand-Linker Conjugate 41	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 ligase Ligand-Linker Conjugate 41 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker* Conjugate 41 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-157600

E3 ligase Ligand-Linker Conjugate 66	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 ligase Ligand-Linker Conjugate 66 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker* Conjugate 66 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-157747

E3 Ligase Ligand-linker Conjugate 99	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 99 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker* Conjugate 99 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-157748

E3 Ligase Ligand-linker Conjugate 100	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 100 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker* Conjugate 100 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162180

E3 Ligase Ligand-linker Conjugate 2	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 2 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker* Conjugate 2 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162203

E3 Ligase Ligand-linker Conjugate 51	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 51 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker* Conjugate 51 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162190

E3 Ligase Ligand-linker Conjugate 17	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 17 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker* Conjugate 17 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162192

E3 Ligase Ligand-linker Conjugate 20	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 20 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker* Conjugate 20 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162206

E3 Ligase Ligand-linker Conjugate 58	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 58 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker* Conjugate 58 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162184

E3 ligase Ligand-Linker Conjugate 11	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 ligase Ligand-Linker Conjugate 11 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker* Conjugate 11 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-157761

E3 Ligase Ligand-linker Conjugate 106	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 106 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker* Conjugate 106 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-157588

(S)-Thalidomide-Piperazine-CH2-Pyrrolidine-C2-OH	E3 Ligase Ligand-Linker Conjugates Autophagy Apoptosis	Cancer
E3 ligase Ligand-Linker Conjugate 30 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker* Conjugate 30 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162200

E3 Ligase Ligand-linker Conjugate 47	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 Ligase Ligand-linker Conjugate 47 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker* Conjugate 47 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

HY-162198

E3 ligase Ligand-Linker Conjugate 43	E3 Ligase Ligand-Linker Conjugates	Cancer
E3 ligase Ligand-Linker Conjugate 43 is a **conjugate of E3 ligase ligand and linker*, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker* Conjugate 43 can serve as Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

Cat. No.	상품명		Classification

HY-W190931

Thalidomide-O-PEG5-alkyne		Alkynes
Thalidomide-O-PEG5-alkyne is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

HY-139332

Pomalidomide 4'-PEG6-azide		Azide
Pomalidomide 4'-PEG6-azide (compound 33e) is the E3 ligase ligand-linker conjugate used in the recruitment of CRBN protein. Pomalidomide 4'-alkylC3-acid can be used to synthesize PROTACs .

HY-139341

Pomalidomide 4'-alkylC3-azide		Azide
Pomalidomide 4'-alkylC3-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC3-azide can be used in the synthesis of PROTAC .

HY-139343

Pomalidomide 4'-alkylC2-azide		Azide
Pomalidomide 4'-alkylC2-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC2-azide can be used in the synthesis of PROTAC .

HY-157510

Thalidomide-O-C3-azide		Azide
Thalidomide-O-C3-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C3-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C3-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .

HY-157511

Thalidomide-O-C5-azide		Azide
Thalidomide-O-C5-azide is a click chemistry modification of the cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide-O-C5-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkyne groups. Thalidomide-O-C5-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .

HY-157515

Thalidomide 4'-ether-PEG2-azide		Azide
Thalidomide 4'-ether-PEG2-azide is a click chemistry modified cereblon (CRBN) inhibitor Thalidomide (HY-14658). Thalidomide 4'-ether-PEG2-azide contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing alkynyl groups. Thalidomide 4'-ether-PEG2-azide can be used as a ligand of E3 ubiquitin ligase and Linker conjugates (E3 Ligase Ligand-Linker Conjugates) for the synthesis of PROTACs .

HY-W998284

Thalidomide-O-C2-alkyne		Alkynes
Thalidomide-O-C2-alkyne is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

Cat. No.	상품명		Classification

HY-174863

Pomalidomide-C2-PEG-NHCO-C2-COOH		Pegylated Lipids
Pomalidomide-C2-PEG-NHCO-C2-COOH is a conjugate of the CRBN ligand (HY-10984) and the linker (E3 Ligase Ligand-Linker Conjugate). Pomalidomide-C2-PEG-NHCO-C2-COOH can be used for synthesizing PROTAC ASK1 degrader dASK1 (HY-174862) .

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