E3 Ligase Ligand-linker Conjugate 13

Cat. No.: HY-162186: Fiche technique Instruction de manipulation
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E3 Ligase Ligand-linker Conjugate 13 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 13 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

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E3 Ligase Ligand-linker Conjugate 13 Chemical Structure

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•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform E3 Ligase Ligand-Linker Conjugates:

Voir toutes les isoformes

von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description	E3 Ligase Ligand-linker Conjugate 13 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 13 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
IC₅₀ & Target	Cereblon (CRBN)^[1]
Masse moléculaire	554.63
Formule	C₂₉H₃₈N₄O₇
SMILES	O=C1NC(CCC1N2C(C3=C(C=CC(N4CCC(CC4)OC5CCN(CC5)CC(OC(C)(C)C)=O)=C3)C2=O)=O)=O
Livraison	Room temperature in continental US; may vary elsewhere.
Stockage	Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation	Fiche technique (265 KB) Instruction de manipulation (2659 KB)
Références	[1]. Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. [Content Brief] [2]. Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203. [Content Brief] [3]. Bian C, et al. Thalidomide (THD) alleviates radiation induced lung fibrosis (RILF) via down-regulation of TGF-β/Smad3 signaling pathway in an Nrf2-dependent manner. Free Radic Biol Med. 2018 Dec;129:446-453. [Content Brief]