E3 Ligase Ligand-linker Conjugate 92
E3 Ligase Ligand-linker Conjugate 92 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 Ligase Ligand-linker Conjugate 92 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.
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- Fòrmula: C25H33N5O6
- Peso molecular:499.56
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
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Chemical Information
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Actividad biológica
Cereblon (CRBN)[1]
Chemical Information
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Peso molecular 499.56
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Fòrmula C25H33N5O6
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SMILES
O=C1NC(CC[C@@H]1N2C(C3=C(C=CC(N4CCN(CC4)CC5CN(C5)CCOCCO)=C3)C2=O)=O)=O
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
[1]. Fischer ES, et al. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature. 2014 Aug 7;512(7512):49-53. [Content Brief]
[2]. Sun X, et al. Synergistic Inhibition of Thalidomide and Icotinib on Human Non-Small Cell Lung Carcinomas Through ERK and AKT Signaling. Med Sci Monit. 2018 May 15;24:3193-3203. [Content Brief]
[3]. Bian C, et al. Thalidomide (THD) alleviates radiation induced lung fibrosis (RILF) via down-regulation of TGF-β/Smad3 signaling pathway in an Nrf2-dependent manner. Free Radic Biol Med. 2018 Dec;129:446-453. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
E3 Ligase Ligand-linker Conjugate 92 Related Classifications
HY-157635 Related Classifications
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