2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Pomalidomide 4'-alkylC3-azide

Pomalidomide 4'-alkylC3-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC3-azide can be used in the synthesis of PROTAC.

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Pomalidomide 4'-alkylC3-azide

Pomalidomide 4'-alkylC3-azide Chemical Structure

CAS No. : 2357108-05-3

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Pomalidomide 4'-alkylC3-azide Related Antibodies

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View All E3 Ligase Ligand-Linker Conjugates Isoform Specific Products:

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor TRIM21

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Description

Pomalidomide 4'-alkylC3-azide (compound 2a) is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide 4'-alkylC3-azide can be used in the synthesis of PROTAC[1].

Molecular Weight

356.34

Formula

C16H16N6O4
CAS No.
Appearance

Solid

Color

Light yellow to brown

SMILES

[N-]=[N+]=NCCCNC1=CC=CC(C(N2C3C(NC(CC3)=O)=O)=O)=C1C2=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (280.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8063 mL 14.0315 mL 28.0631 mL
5 mM 0.5613 mL 2.8063 mL 5.6126 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8063 mL 14.0315 mL 28.0631 mL 70.1577 mL
5 mM 0.5613 mL 2.8063 mL 5.6126 mL 14.0315 mL
10 mM 0.2806 mL 1.4032 mL 2.8063 mL 7.0158 mL
15 mM 0.1871 mL 0.9354 mL 1.8709 mL 4.6772 mL
20 mM 0.1403 mL 0.7016 mL 1.4032 mL 3.5079 mL
25 mM 0.1123 mL 0.5613 mL 1.1225 mL 2.8063 mL
30 mM 0.0935 mL 0.4677 mL 0.9354 mL 2.3386 mL
40 mM 0.0702 mL 0.3508 mL 0.7016 mL 1.7539 mL
50 mM 0.0561 mL 0.2806 mL 0.5613 mL 1.4032 mL
60 mM 0.0468 mL 0.2339 mL 0.4677 mL 1.1693 mL
80 mM 0.0351 mL 0.1754 mL 0.3508 mL 0.8770 mL
100 mM 0.0281 mL 0.1403 mL 0.2806 mL 0.7016 mL
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Pomalidomide 4'-alkylC3-azide Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide 4'-alkylC3-azide2357108-05-3E3 Ligase Ligand-Linker ConjugatesVHLPROTACE3 Ligase LigandInhibitorinhibitorinhibit

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