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Cat. No.: HY-185558

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N-Methylthalidomide-Pip-NHBoc

N-Methylthalidomide-Pip-NHBoc is an E3 ligase ligand-linker conjugate that incorporates the CRBN ligand and a linker. N-Methylthalidomide-Pip-NHBoc can be used to synthesize LLC0424N (HY-185557) .

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

CAS No.: 3061315-50-9
화학식: C₂₄H₃₀N₄O₆
분자량:470.52

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

N-Methylthalidomide-Pip-NHBoc Chemical Structure

CAS No.: 3061315-50-9

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

N-Methylthalidomide-Pip-NHBoc is an E3 ligase ligand-linker conjugate that incorporates the CRBN ligand and a linker. N-Methylthalidomide-Pip-NHBoc can be used to synthesize LLC0424N (HY-185557) ^[1].

All E3 Ligase Ligand-Linker Conjugates Isoforms :

In Vitro

PROTAC consists of two distinct ligands linked by a linker; one is the ligand of E3 ubiquitin ligase, and the other is the ligand of the target protein. PROTAC selectively degrades target proteins by utilizing the intracellular ubiquitin-proteasome system.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3061315-50-9
분자량 470.52
화학식 C₂₄H₃₀N₄O₆
SMILES

O=C(NC1CCN(CC1)C2=CC=C3C(N(C4C(N(C)C(CC4)=O)=O)C(C3=C2)=O)=O)OC(C)(C)C
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Lianchao Liu, et al. Discovery of LLC0424 as a Potent and Selective in Vivo NSD2 PROTAC Degrader. J Med Chem. 2024 May 9;67(9):6938-6951. [Content Brief]

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Biological Activity
- 제품 설명
- In Vitro
Chemical Information
순도&문서
References

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N-Methylthalidomide-Pip-NHBoc

All E3 Ligase Ligand-Linker Conjugates Isoforms