PROTAC HDAC degrader-2 TFA

Cat. No.: HY-174444A Purity: 96.68%: Data Sheet
COA

SDS
Handling Instructions
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PROTAC HDAC degrader-2 TFA is the trifluoroacetate salt of PROTAC HDAC degrader-2. PROTAC HDAC degrader-2 is a selective IIb HDACs PROTAC degrader, with DC₅₀s of 13 nM for HDAC6, 29 nM for HDAC10, respectively. PROTAC HDAC degrader-2 exhibits low cytotoxicity against hematological and solid cancer cell lines. PROTAC HDAC degrader-2 can be used for the chemical knockdown of class IIb HDACs. ( Pink: HDAC ligand : (HY-174471), Blue: E3 ligase CRBN Ligand (HY-131717), E3 ligase ligand-linker conjugate (HY-174473)).

For research use only. We do not sell to patients.

PROTAC HDAC degrader-2 TFA Chemical Structure

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of PROTAC HDAC degrader-2 TFA:

PROTAC HDAC degrader-2 Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

847.84

Formula

C₄₂H₄₄F₃N₇O₉

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1CCC(C(N1)=O)N2C(C3=CC=CC(NCC(NCCCCCCN4CCC5=C(C6=CC=CC=C6N5CC7=CC=C(C=C7)C(NO)=O)C4)=O)=C3C2=O)=O.OC(C(F)(F)F)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (117.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.1795 mL	5.8973 mL	11.7947 mL
5 mM	0.2359 mL	1.1795 mL	2.3589 mL
10 mM	0.1179 mL	0.5897 mL	1.1795 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 96.68%

Select Batch:

Data Sheet (274 KB) SDS (252 KB)

COA (252 KB) HNMR (152 KB) RP-HPLC (190 KB) LCMS (198 KB)

Handling Instructions (2659 KB)

References

[1]. Zhai S, et al. Development and Characterization of the First Selective Class IIb Histone Deacetylase Degraders. J Med Chem. 2025 Jul 10;68(13):13793-13821. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.1795 mL	5.8973 mL	11.7947 mL	29.4867 mL
	5 mM	0.2359 mL	1.1795 mL	2.3589 mL	5.8973 mL
	10 mM	0.1179 mL	0.5897 mL	1.1795 mL	2.9487 mL
	15 mM	0.0786 mL	0.3932 mL	0.7863 mL	1.9658 mL
	20 mM	0.0590 mL	0.2949 mL	0.5897 mL	1.4743 mL
	25 mM	0.0472 mL	0.2359 mL	0.4718 mL	1.1795 mL
	30 mM	0.0393 mL	0.1966 mL	0.3932 mL	0.9829 mL
	40 mM	0.0295 mL	0.1474 mL	0.2949 mL	0.7372 mL
	50 mM	0.0236 mL	0.1179 mL	0.2359 mL	0.5897 mL
	60 mM	0.0197 mL	0.0983 mL	0.1966 mL	0.4914 mL
	80 mM	0.0147 mL	0.0737 mL	0.1474 mL	0.3686 mL
	100 mM	0.0118 mL	0.0590 mL	0.1179 mL	0.2949 mL