PROTAC HDAC degrader-2 TFA
Based on 1 Customer Validation
PROTAC HDAC degrader-2 TFA is the trifluoroacetate salt of PROTAC HDAC degrader-2. PROTAC HDAC degrader-2 is a selective IIb HDACs PROTAC degrader, with DC50s of 13 nM for HDAC6, 29 nM for HDAC10, respectively. PROTAC HDAC degrader-2 exhibits low cytotoxicity against hematological and solid cancer cell lines. PROTAC HDAC degrader-2 can be used for the chemical knockdown of class IIb HDACs.
(Pink: HDAC6 and HDAC10 ligand (HY-174471); Blue: Cereblon ligand (HY-131717); Black: linker).
For research use only. We do not sell to patients.
- Purity: 96.68%
- Formula: C42H44F3N7O9
- Molecular Weight:847.84
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Storage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All PROTACs Isoforms
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Biological Activity
Chemical Information
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Appearance Solid
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Molecular Weight 847.84
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Formula C42H44F3N7O9
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Color Light yellow to yellow
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SMILES
O=C1CCC(C(N1)=O)N2C(C3=CC=CC(NCC(NCCCCCCN4CCC5=C(C6=CC=CC=C6N5CC7=CC=C(C=C7)C(NO)=O)C4)=O)=C3C2=O)=O.OC(C(F)(F)F)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (117.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.1795 mL | 5.8973 mL | 11.7947 mL | 29.4867 mL |
| 5 mM | 0.2359 mL | 1.1795 mL | 2.3589 mL | 5.8973 mL | |
| 10 mM | 0.1179 mL | 0.5897 mL | 1.1795 mL | 2.9487 mL | |
| 15 mM | 0.0786 mL | 0.3932 mL | 0.7863 mL | 1.9658 mL | |
| 20 mM | 0.0590 mL | 0.2949 mL | 0.5897 mL | 1.4743 mL | |
| 25 mM | 0.0472 mL | 0.2359 mL | 0.4718 mL | 1.1795 mL | |
| 30 mM | 0.0393 mL | 0.1966 mL | 0.3932 mL | 0.9829 mL | |
| 40 mM | 0.0295 mL | 0.1474 mL | 0.2949 mL | 0.7372 mL | |
| 50 mM | 0.0236 mL | 0.1179 mL | 0.2359 mL | 0.5897 mL | |
| 60 mM | 0.0197 mL | 0.0983 mL | 0.1966 mL | 0.4914 mL | |
| 80 mM | 0.0147 mL | 0.0737 mL | 0.1474 mL | 0.3686 mL | |
| 100 mM | 0.0118 mL | 0.0590 mL | 0.1179 mL | 0.2949 mL |
PROTAC HDAC degrader-2 TFA Related Classifications
HY-174444A Related Classifications
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