FAK ligand-Linker Conjugate 1

Cat. No.: HY-44148 Purity: 98.91%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

FAK ligand-Linker Conjugate 1 incorporates a ligand for FAK, and a PROTAC linker, which recruit E3 ligases (such as VHL, CRBN, MDM2, and IAP). FAK ligand-Linker Conjugate 1 can be extensively used for PROTAC-mediated protein degradation.

For research use only. We do not sell to patients.

FAK ligand-Linker Conjugate 1 Chemical Structure

CAS No. : 2307461-45-4

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 1258	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 1258	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	USD 550	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 980	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 1500	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

Molecular Weight

583.58

Formula

C₂₅H₂₈F₃N₅O₆S

CAS No.

2307461-45-4

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCOCCOC1=CC=C(NC2=NC=C(C(F)(F)F)C(NCC3=CC=CC(N(C)S(=O)(C)=O)=C3)=N2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (171.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7136 mL	8.5678 mL	17.1356 mL
5 mM	0.3427 mL	1.7136 mL	3.4271 mL
10 mM	0.1714 mL	0.8568 mL	1.7136 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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mg/kg

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.91%

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Data Sheet (265 KB) SDS (0 KB)

COA (244 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Cromm PM, et al. Addressing Kinase-Independent Functions of Fak via PROTAC-Mediated Degradation. J Am Chem Soc. 2018 Dec 12;140(49):17019-17026. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7136 mL	8.5678 mL	17.1356 mL	42.8390 mL
	5 mM	0.3427 mL	1.7136 mL	3.4271 mL	8.5678 mL
	10 mM	0.1714 mL	0.8568 mL	1.7136 mL	4.2839 mL
	15 mM	0.1142 mL	0.5712 mL	1.1424 mL	2.8559 mL
	20 mM	0.0857 mL	0.4284 mL	0.8568 mL	2.1420 mL
	25 mM	0.0685 mL	0.3427 mL	0.6854 mL	1.7136 mL
	30 mM	0.0571 mL	0.2856 mL	0.5712 mL	1.4280 mL
	40 mM	0.0428 mL	0.2142 mL	0.4284 mL	1.0710 mL
	50 mM	0.0343 mL	0.1714 mL	0.3427 mL	0.8568 mL
	60 mM	0.0286 mL	0.1428 mL	0.2856 mL	0.7140 mL
	80 mM	0.0214 mL	0.1071 mL	0.2142 mL	0.5355 mL
	100 mM	0.0171 mL	0.0857 mL	0.1714 mL	0.4284 mL