2. PROTAC Autophagy
  3. Ligands for E3 Ligase Autophagy
  4. E3 ligase Ligand-Linker Conjugate 37

E3 ligase Ligand-Linker Conjugate 37 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker Conjugate 37 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

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E3 ligase Ligand-Linker Conjugate 37 Chemical Structure

E3 ligase Ligand-Linker Conjugate 37 Chemical Structure

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E3 ligase Ligand-Linker Conjugate 37 Related Antibodies

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Description

E3 ligase Ligand-Linker Conjugate 37 is a conjugate of E3 ligase ligand and linker, consisting of Thalidomide (HY-14658) and the corresponding Linker. E3 ligase Ligand-Linker Conjugate 37 can serve as a Cereblon ligand to recruit CRBN protein and serve as a key intermediate for the synthesis of complete PROTAC molecules.

IC50 & Target

Cereblon (CRBN)[1]
Molecular Weight

598.69

Formula

C31H42N4O8
SMILES

O=C1NC(CCC1N2C(C3=C(C=CC(N4CCC(CC4)OC5CCN(CC5)CCOCC(OC(C)(C)C)=O)=C3)C2=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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E3 ligase Ligand-Linker Conjugate 37 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

E3 ligase Ligand-Linker Conjugate 37Ligands for E3 LigaseAutophagyE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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