Thalidomide-4-O-C11-Br
Thalidomide-4-O-C11-Br is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based CRBN ligand and a linker used in PROTAC technology. Thalidomide-4-O-C11-Br can be connected to the ligand for protein by a linker to form PROTAC EZH2 Degrader-23 (HY-181324).
For research use only. We do not sell to patients.
- CAS No.: 2653338-58-8
- Formula: C24H31BrN2O5
- Molecular Weight:507.42
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All E3 Ligase Ligand-Linker Conjugates Isoforms
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Biological Activity
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2653338-58-8
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Molecular Weight 507.42
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Formula C24H31BrN2O5
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SMILES
O=C(C(CC1)N(C2=O)C(C(C2=CC=C3)=C3OCCCCCCCCCCCBr)=O)NC1=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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