PROTAC HPK1 Degrader-4
PROTAC HPK1 Degrader-4 (compound E3) is a selective and orally active PROTAC HPK1 degrader with a DC50 of 3.16 nM. PROTAC HPK1 Degrader-4 demonstrates >1000-fold selectivity over GLK. PROTAC HPK1 Degrader-4 promotes immune activation. PROTAC HPK1 Degrader-4 can be used for the study of colon cancer and lymphoma (Pink: ligand for target protein (HY-174355); Blue: ligand for E3 ligase CRBN (HY-45808); Black: Linker (HY-174356); Target protein ligand-linker Conjugate (HY-174357)).
(Pink: HPK1 ligand (HY-174355); Blue: Cereblon ligand (HY-45808); Black: linker (HY-174356)).
For research use only. We do not sell to patients.
- Formula: C46H46N8O5
- Molecular Weight:790.91
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Chemical Information
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Molecular Weight 790.91
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Formula C46H46N8O5
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SMILES
O=C1N(C(C2=CC(N3CC(C3)CN4CC=C(CC4)C5=C(C=C(C=C5C)C6=NC7=C(N=C6)NC=C7C8=CC(C)=C(C=C8)C(N(C)C)=O)C)=CC=C21)=O)C9C(NC(CC9)=O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PROTAC HPK1 Degrader-4 Related Classifications
HY-174135 Related Classifications
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