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Cat. No.: HY-174135

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PROTAC HPK1 Degrader-4

PROTAC HPK1 Degrader-4 (compound E3) is a selective and orally active PROTAC HPK1 degrader with a DC₅₀ of 3.16 nM. PROTAC HPK1 Degrader-4 demonstrates >1000-fold selectivity over GLK. PROTAC HPK1 Degrader-4 promotes immune activation. PROTAC HPK1 Degrader-4 can be used for the study of colon cancer and lymphoma (Pink: ligand for target protein (HY-174355); Blue: ligand for E3 ligase CRBN (HY-45808); Black: Linker (HY-174356); Target protein ligand-linker Conjugate (HY-174357)).
(Pink: HPK1 ligand (HY-174355); Blue: Cereblon ligand (HY-45808); Black: linker (HY-174356)).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₄₆H₄₆N₈O₅
Masse moléculaire:790.91

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

PROTAC HPK1 Degrader-4 Chemical Structure

Size

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Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

PROTAC HPK1 Degrader-4 (compound E3) is a selective and orally active PROTAC HPK1 degrader with a DC₅₀ of 3.16 nM. PROTAC HPK1 Degrader-4 demonstrates >1000-fold selectivity over GLK. PROTAC HPK1 Degrader-4 promotes immune activation. PROTAC HPK1 Degrader-4 can be used for the study of colon cancer and lymphoma (Pink: ligand for target protein (HY-174355); Blue: ligand for E3 ligase CRBN (HY-45808); Black: Linker (HY-174356); Target protein ligand-linker Conjugate (HY-174357))^[1]. (Pink: HPK1 ligand (HY-174355); Blue: Cereblon ligand (HY-45808); Black: linker (HY-174356)).

Voir tous les produits spécifiques à Isoform PROTACs :

Voir tous les produits spécifiques à Isoform MAP4K :

Chemical Information

Masse moléculaire 790.91
Formule C₄₆H₄₆N₈O₅
SMILES

O=C1N(C(C2=CC(N3CC(C3)CN4CC=C(CC4)C5=C(C=C(C=C5C)C6=NC7=C(N=C6)NC=C7C8=CC(C)=C(C=C8)C(N(C)C)=O)C)=CC=C21)=O)C9C(NC(CC9)=O)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Wu M, et al. Discovery of a New and Selective HPK1 PROTAC for Enhancing Tumor Immunotherapy through Eliminating GLK Degradation. J Med Chem. 2025 Jun 12;68(11):10800-10822. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
Chemical Information
Pureté et documentation
Références

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Cat. No.:
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MCE Japan Authorized Agent:

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PROTAC HPK1 Degrader-4

Voir tous les produits spécifiques à Isoform PROTACs

Voir tous les produits spécifiques à Isoform MAP4K

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

PROTAC HPK1 Degrader-4 Related Classifications

HY-174135 Related Classifications