Pomalidomide-5'-C8-acid

Cat. No.: HY-160017: FAQs
Data Sheet Handling Instructions

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Pomalidomide-5'-C8-acid (Compound 3d') is an E3 ligase ligand-linker conjugate containing a Pomalidomide (HY-10984) based cereblon (CRBN) ligand and a linker. Pomalidomide-5'-C8-acid can be used in the synthesis of PROTACs.

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Pomalidomide-5'-C8-acid Chemical Structure

CAS No. : 2682112-09-8

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

429.47

Formula

C₂₂H₂₇N₃O₆

CAS No.

2682112-09-8

Appearance

Solid

Color

Light yellow to green yellow

SMILES

O=C(CCCCCCCCNC1=CC=C2C(N(C3C(NC(CC3)=O)=O)C(C2=C1)=O)=O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (232.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3285 mL	11.6423 mL	23.2845 mL
5 mM	0.4657 mL	2.3285 mL	4.6569 mL
10 mM	0.2328 mL	1.1642 mL	2.3285 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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Dosing volume
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μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Rao, Yu, et al. Preparation of isoindoline derivatives as degradation agent targeting both BTK and GSPT1 proteins and its application. Patent. CN115304606

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3285 mL	11.6423 mL	23.2845 mL	58.2113 mL
	5 mM	0.4657 mL	2.3285 mL	4.6569 mL	11.6423 mL
	10 mM	0.2328 mL	1.1642 mL	2.3285 mL	5.8211 mL
	15 mM	0.1552 mL	0.7762 mL	1.5523 mL	3.8808 mL
	20 mM	0.1164 mL	0.5821 mL	1.1642 mL	2.9106 mL
	25 mM	0.0931 mL	0.4657 mL	0.9314 mL	2.3285 mL
	30 mM	0.0776 mL	0.3881 mL	0.7762 mL	1.9404 mL
	40 mM	0.0582 mL	0.2911 mL	0.5821 mL	1.4553 mL
	50 mM	0.0466 mL	0.2328 mL	0.4657 mL	1.1642 mL
	60 mM	0.0388 mL	0.1940 mL	0.3881 mL	0.9702 mL
	80 mM	0.0291 mL	0.1455 mL	0.2911 mL	0.7276 mL
	100 mM	0.0233 mL	0.1164 mL	0.2328 mL	0.5821 mL