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Topoisomerase+II+Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	ADC Payload (15) AMPK (3) Antibiotic (19) Apoptosis (39) Autophagy (17) Bacterial (25) Bcl-2 Family (1) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (10) Drug-Linker Conjugates for ADC (3) Endogenous Metabolite (7) Fluorescent Dye (3) Fungal (3) HBV (3) HIV (3) Isotope-Labeled Compounds (7) Liposome (2) Mitophagy (3) NO Synthase (1) Orthopoxvirus (7) Parasite (3) PEPCK (1) PKC (9) Reference Standards (14) Topoisomerase (107)
By Research Areas:	Cancer (98) Cardiovascular Disease (2) Infection (37) Inflammation/Immunology (3) Metabolic Disease (1) Neurological Disease (11)
Oligonucleotides:	Liposome (2)

110

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

GMP Molecules

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15142

Doxorubicin hydrochloride Maximum Cited Publications 650 Publications Verification Hydroxydaunorubicin hydrochloride; ADR	Topoisomerase ADC Payload AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial Fluorescent Dye	Infection Cancer
Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human *DNA topoisomerase* I and topoisomerase II** inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

HY-13062

Daunorubicin hydrochloride 35+ Cited Publications Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride	Topoisomerase DNA/RNA Synthesis ADC Payload Bacterial Autophagy Apoptosis Antibiotic	Infection Neurological Disease Cancer
Daunorubicin (Daunomycin) hydrochloride is a *topoisomerase II* inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-13502

Mitoxantrone 45+ Cited Publications Mitozantrone; NSC 301739	Topoisomerase PKC Orthopoxvirus Apoptosis Endogenous Metabolite	Infection Cancer
Mitoxantrone is a potent *topoisomerase II* inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity . Mitoxantrone also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-13630

Etoposide phosphate 170+ Cited Publications BMY-40481	Topoisomerase Bacterial Autophagy Apoptosis	Infection Neurological Disease Cancer
Etoposide phosphate (BMY-40481) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate is the phosphate ester proagent of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate induces cell cycle arrest, apoptosis, and autophagy.

HY-16700

PNU-159682	ADC Payload Topoisomerase	Cancer
PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome agent resistance.

HY-13062A

Daunorubicin 35+ Cited Publications Daunomycin; RP 13057; Rubidomycin	Topoisomerase DNA/RNA Synthesis ADC Payload Autophagy Bacterial Antibiotic Apoptosis	Infection Neurological Disease Cancer
Daunorubicin (Daunomycin) is a *topoisomerase II* inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-13502A

Mitoxantrone dihydrochloride 45+ Cited Publications Mitozantrone dihydrochloride; NSC 301739 dihydrochloride	Topoisomerase PKC Orthopoxvirus Apoptosis Endogenous Metabolite	Infection Cancer
Mitoxantrone dihydrochloride is a potent *topoisomerase II* inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-15142R

Doxorubicin hydrochloride (Standard) 5 Publications Verification Hydroxydaunorubicin hydrochloride (Standard); ADR (Standard)	Reference Standards Topoisomerase ADC Payload AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial Fluorescent Dye	Infection Cancer
Doxorubicin hydrochloride (Standard) is the analytical standard of Doxorubicin hydrochloride. This product is intended for research and analytical applications. Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human *DNA topoisomerase* I and topoisomerase II** inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

HY-13761

Teniposide 10+ Cited Publications VM26	Topoisomerase	Cancer
Teniposide is a podophyllotoxin derivative, acts as a *topoisomerase II* inhibitor, and used as a chemotherapeutic agent.

HY-116063

Doxorubicin-SMCC 1 Publications Verification	Drug-Linker Conjugates for ADC	Cancer
Doxorubicin-SMCC is a agent-linker conjugate for ADC. Doxorubicin-SMCC contains a non-cleavable ADC linker and a DNA topoisomerase II inhibitor Doxorubicin .

HY-16261

Aldoxorubicin 20+ Cited Publications INNO-206; DOXO-EMCH	Topoisomerase ADC Payload	Cancer
Aldoxorubicin (INNO-206) is an albumin-binding proagent of Doxorubicin (DNA topoisomerase II inhibitor), which is released from albumin under acidic conditions. Aldoxorubicin (INNO-206) has potent antitumor activities in various cancer cell lines and in murine tumor models.

HY-15142A

Doxorubicin Hydroxydaunorubicin	ADC Payload Antibiotic Bacterial Topoisomerase AMPK HIV Autophagy Mitophagy Apoptosis HBV Fluorescent Dye	Infection Cancer
Doxorubicin (Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin is a potent human *DNA topoisomerase* I and topoisomerase II** inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin induces apoptosis and autophagy .

HY-13725

Pirarubicin 25+ Cited Publications THP	Topoisomerase Autophagy Bacterial Antibiotic	Infection Cancer
Pirarubicin is an anthracycline antibiotics, acts as a *topoisomerase II* inhibitor, and is a widely used for treatment of various cancers, in particular, solid tumors.

HY-13725A

Pirarubicin Hydrochloride 25+ Cited Publications THP Hydrochloride	Topoisomerase Autophagy Bacterial Antibiotic	Infection Cancer
Pirarubicin Hydrochloride is an anthracycline antibiotics, acts as a *topoisomerase II* inhibitor, and is a widely used for treatment of various cancers, in particular, solid tumors.

HY-B0526

Flumequine 3 Publications Verification R-802	Bacterial Topoisomerase Antibiotic	Infection Cancer
Flumequine (R-802) is a quinolone antibiotic, and acts as a *topoisomerase II* inhibitor, with an IC₅₀ of 15 μM (3.92 μg/mL).

HY-13727A

Pixantrone 3 Publications Verification BBR 2778	Topoisomerase	Cancer
Pixantrone (BBR 2778) dimaleate is a *topoisomerase II* inhibitor and DNA intercalator, with anti-tumor activity.

HY-10982

Amonafide 4 Publications Verification AS1413	Topoisomerase	Cancer
Amonafide is a *topoisomerase II* inhibitor and DNA intercalator that induces apoptotic signaling by blocking the binding of Topo II to DNA.

HY-13562A

Banoxantrone dihydrochloride 5+ Cited Publications AQ4N dihydrochloride	Topoisomerase	Cancer
Banoxantrone dihydrochloride is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent *topoisomerase II* inhibitor.

HY-10534

Voreloxin 3 Publications Verification SNS-595; Vosaroxin; AG 7352	Topoisomerase Apoptosis	Cancer
Voreloxin (SNS-595; Vosaroxin; AG 7352) is a first-in-class *topoisomerase II* inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis.

HY-16261B

MC-DOXHZN hydrochloride 5 Publications Verification (E/Z)-Aldoxorubicin hydrochloride; Doxorubicin(6-maleimidocaproyl)hydrazone hydrochloride	ADC Payload Topoisomerase	Cancer
MC-DOXHZN ((E/Z)-Aldoxorubicin; Doxorubicin(6-maleimidocaproyl)hydrazone) hydrochloride is an albumin-binding proagent of Doxorubicin (HY-15142A) (DNA topoisomerase II inhibitor), with acid-sensitive properties. MC-DOXHZN hydrochloride can be used to synthesize ADC .

HY-B0067

Amrubicin SM-5887	Topoisomerase Bacterial	Cancer
Amrubicin (SM-5887) is a DNA *topoisomerase II* inhibitor, used for the research of cancer.

HY-16518

Voreloxin Hydrochloride 3 Publications Verification SNS-595 Hydrochloride; Vosaroxin Hydrochloride; AG 7352 Hydrochloride	Topoisomerase Apoptosis	Cancer
Voreloxin Hydrochloride is a first-in-class *topoisomerase II* inhibitor that intercalates DNA and induces site-selective DNA DSB, G2 arrest, and apoptosis.

HY-153401

Topoisomerase II inhibitor 13	Topoisomerase	Cancer
Topoisomerase II inhibitor 13 is a topoisomerase II (Topo II) inhibitor. Topoisomerase II inhibitor 13 shows antiproliferative activity against several cancer cells. Topoisomerase II inhibitor 13 induces cancer cells apoptosis .

HY-16261A

MC-DOXHZN (E/Z)-Aldoxorubicin; Doxorubicin(6-maleimidocaproyl)hydrazone	ADC Payload Topoisomerase	Cancer
MC-DOXHZN ((E/Z)-Aldoxorubicin; Doxorubicin(6-maleimidocaproyl)hydrazone) is an albumin-binding proagent of Doxorubicin (HY-15142A) (DNA topoisomerase II inhibitor), with acid-sensitive properties. MC-DOXHZN can be used to synthesize ADC .

HY-119425

Razoxane ICRF 159	Topoisomerase	Cancer
Razoxane (ICRF 159), a EDTA (HY-Y0682) derivative, is an orally active antiangiogenic *topoisomerase II* inhibitor. Razoxane has antineoplastic, antiangiogenic, and antimetastatic activities. Razoxanecan be used for the research of renal cell carcinoma (RCC), lung cancer and melanoma cancer .

HY-160774

Val-Cit-PABC-DOX	Drug-Linker Conjugates for ADC Topoisomerase	Cancer
Val-Cit-PABC-DOX (compound 10109), an epsilon-poly-L-lysine-based drug conjugate, is an agent-linker conjugate for ADC by using a DNA topoisomerase I and topoisomerase II inhibitor, Doxorubicin (HY-15142), linked via the linker, Val-Cit-PABC .

HY-175741

IID432	Parasite Topoisomerase	Infection
IID432 is a Trypanosoma cruzi *Topoisomerase II* inhibitor with an EC₅₀ of 8  nM for Trypanosoma cruzi. IID432, a single dose of 25 mg/kg, can achieve relapse-free parasite clearance in mouse models of chronic Chagas disease. IID432 can be used for Chagas disease research .

HY-13562

Banoxantrone AQ4N	NO Synthase	Cancer
Banoxantrone (AQ4N), as a prototype hypoxia selective cytotoxin, can be reduced to AQ4, a potent *topoisomerase II* inhibitor. Banoxantrone selectively kills hypoxic cells via an iNOS-dependent mechanism. Banoxantrone shows a potent cytotoxicity and hypoxia-selective effect enhanced by radiation .

HY-13620

Elinafide LU 79553	Topoisomerase	Cancer
Elinafide is an anticancer agent with a naphthalimide structure that targets DNA. Elinafide interferes with cell metabolism by inserting a planar ring into the DNA double helix and interacting with enzymes through its side chain.LU-79553 is a DNA-binding *topoisomerase II* inhibitor. The IC₅₀ value of Elinafide for HT-29 cells is 0.014 μM .

HY-106582

Sobuzoxane MST 16	Topoisomerase	Neurological Disease Cancer
Sobuzoxane (MST-16) is an orally active *topoisomerase II* inhibitor. Sobuzoxane causes irreversible inhibition of cell division. Sobuzoxane can be used in the study of non-Hodgkin's lymphoma that is resistant to conventional chemotherapy or has recurred .

HY-174404

Topoisomerase II inhibitor 23	Topoisomerase Apoptosis Bcl-2 Family	Cancer
Topoisomerase II inhibitor 23 is a potent *topoisomerase II* inhibitor (IC₅₀= 0.94 μM). Topoisomerase II inhibitor 23 shows high selectivity and exceptional cytotoxic activity in MCF-7, HepG2, and HCT116 cells. Topoisomerase II inhibitor 23 induces cell cycle arrest at the G1 phase, leading to inhibition of cell proliferation. Topoisomerase II inhibitor 2 induces apoptosis by up-regulating the pro-apoptotic Bax level and down-regulating the anti-apoptotic Bcl-2 level.

HY-147839

Topoisomerase II inhibitor 10	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 10 (compound 32a) is a potent *topoisomerase II* inhibitor with an IC₅₀ value of 7.45 μM. Topoisomerase II inhibitor 10 causes cell cycle arrest at G2-M phase and induces apoptosis of HepG-2 cells. Topoisomerase II inhibitor 10 has excellent anti-proliferative activities against HepG-2, MCF-7, and HCT-116 cells .

HY-B0067A

Amrubicin hydrochloride SM-5887 hydrochloride	Topoisomerase Bacterial	Cancer
Amrubicin (SM-5887) hydrochloride is a DNA *topoisomerase II* inhibitor, used for the research of cancer.

HY-152965

Biotin-doxorubicin	Topoisomerase Antibiotic Apoptosis Autophagy	Infection Cancer
Biotin-doxorubicin is a Biotin-labeled Doxorubicin. Doxorubicin, a broad-spectrum anthracycline antibiotic, is a *topoisomerase II* inhibitor .

HY-13727

Pixantrone free base BBR 2778 free base	Topoisomerase	Cancer
Pixantrone (BBR 2778 (free base)), a mitoxantrone analog, is a *topoisomerase II* inhibitor and DNA intercalator, with anti-tumor activity.

HY-12888

AZD5099	Topoisomerase Bacterial	Infection
AZD5099, an antibacterial agent, is a potent and selective bacterial topoisomerase II inhibitor. AZD5099 potently inhibits the infections caused by Gram-positive and fastidious Gram-negative bacteria .

HY-120679

XK469 NSC 697887	Topoisomerase	Neurological Disease Cancer
XK469 (NSC 697887) is a quinoxaline-based *topoisomerase II* inhibitor. XK469 exhibits antiproliferative activity against neuroblastoma cells. XK469 can be used in the research of neuroblastoma .

HY-13630A

Etoposide phosphate disodium BMY-40481 disodium	Topoisomerase Autophagy Apoptosis	Neurological Disease Cancer
Etoposide phosphate disodium (BMY-40481 disodium) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate disodium is the phosphate ester proagent of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate disodium induces cell cycle arrest, apoptosis, and autophagy.

HY-143279

Topoisomerase II inhibitor 3	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 3 (Compound 6 h ) is a acridone derivatives, as well as a Type II DNA topoisomerase (topo II) inhibitor , as a topo IIα/β inhibitor with the value of IC₅₀ is 0.17 μM for topo IIα and the value of IC₅₀ is 0.23 μM for topo IIβ subtypes, caused obvious DNA damage, and induced apoptosis by triggering the loss of mitochondrial membrane potential .

HY-155645

Topoisomerase II inhibitor 15	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 15 (compound 2g) is a *Topoisomerase II* inhibitor. Topoisomerase II inhibitor 15 potently is an apoptotic inducer with greater selectivity against head and neck tumors .

HY-162381

Topoisomerase II inhibitor 19	Topoisomerase	Cancer
Topoisomerase II inhibitor 19 (compound 5h) is a DNA intercalator and *topoisomerase II* inhibitor (IC₅₀ value of 0.34 μM). Topoisomerase II inhibitor 19 would induce detectable potent damage in ctDNA .

HY-143281

Topoisomerase II inhibitor 5	Topoisomerase	Cancer
Topoisomerase II inhibitor 5 (Compound E24) is a DNA *topoisomerase II* inhibitor with anticancer activities .

HY-158061

Topoisomerase II inhibitor 20	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 20 (Compound 3e) is a potent topoisomerase II (Topoisomerase II) inhibitor with an IC₅₀ of 0.98 µM. Topoisomerase II inhibitor 20 induces apoptosis and has broad-spectrum anticancer activity .

HY-146227

*DNA topoisomerase II inhibitor* 1**	Topoisomerase Apoptosis	Cancer
DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .

HY-W278582

Topoisomerase II inhibitor 14	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 14 is a potent topoisomerase II inhibtor. Topoisomerase II inhibitor 14 induces apoptosis and arrests cell cycle at S phase and G2-M phases. Topoisomerase II inhibitor 14 exhibits antioxidant effect and decreases the level of GSH, MDA, and NO. Topoisomerase II inhibitor 14 can be used for the study of neck squamous cell carcinoma (HNSCC) .

HY-146316

Topoisomerase II inhibitor 6	Topoisomerase	Cancer
Topoisomerase II inhibitor 6 (Compound 5), a tryptanthrin derivative, is a potent and selective inhibitor of topoisomerase II. Topoisomerase II inhibitor 6 exhibits antiproliferative activity on different tumor cell lines. Topoisomerase II inhibitor 6 blocks the cell cycle of CCRF-CEM in the G2 phase and induces DNA DSB. Topoisomerase II inhibitor 6 has the potential for the research of cancer diseases .

HY-155693

Topoisomerase II inhibitor 16	Topoisomerase Parasite	Infection
Topoisomerase II inhibitor 16 (compound CT3) is a selective, orally active, brain-penetrant and irreversible trypanosomal topoisomerase II inhibitor by stabilizing double-stranded DNA:enzyme cleavage complexes. Topoisomerase II inhibitor 16 has the potential for Chagas disease research .

HY-143280

Topoisomerase II inhibitor 4	Topoisomerase	Cancer
Topoisomerase II inhibitor 4 (compound E17) is a potent *Topoisomerase II* inhibitor. Topoisomerase II inhibitor 4 triggers G2/M cell cycle arrest and shows anti-tumor activity with strong cytotoxic and anti-proliferative effect .

HY-146188

Topoisomerase II inhibitor 8	Topoisomerase	Cancer
Topoisomerase II inhibitor 8 (compound 22) is a potent *topoisomerase II* inhibitor, with an IC₅₀ of 0.52 μM. Topoisomerase II inhibitor 8 exhibits good anti-proliferative activities and can arrest the cell cycle at G2/M phase .

HY-158061A

Topoisomerase II inhibitor 20 TFA	Topoisomerase Apoptosis	Cancer
Topoisomerase II inhibitor 20 TFA is a potent *topoisomerase II* inhibitor with IC₅₀ of 0.98 µM. Topoisomerase II inhibitor 20 TFA can induce apoptosis and has broad-spectrum anticancer activity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-15142

Doxorubicin hydrochloride Maximum Cited Publications 650 Publications Verification Hydroxydaunorubicin hydrochloride; ADR	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Disease Research Fields Source Classification	Topoisomerase ADC Payload AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial Fluorescent Dye
Doxorubicin hydrochloride (Hydroxydaunorubicin hydrochloride; ADR), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human *DNA topoisomerase* I and topoisomerase II** inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

HY-13062

Daunorubicin hydrochloride 35+ Cited Publications Daunomycin hydrochloride; RP 13057 hydrochloride; Rubidomycin hydrochloride	Infection Quinones Microorganisms Classification of Application Fields Anthraquinones Phenols Polyphenols Disease Research Fields Source Classification	Topoisomerase DNA/RNA Synthesis ADC Payload Bacterial Autophagy Apoptosis Antibiotic
Daunorubicin (Daunomycin) hydrochloride is a *topoisomerase II* inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-13502

Mitoxantrone 45+ Cited Publications Mitozantrone; NSC 301739	Infection Quinones Classification of Application Fields Anthraquinones Endogenous metabolite Disease Research Fields Source Classification Cancer	Topoisomerase PKC Orthopoxvirus Apoptosis Endogenous Metabolite
Mitoxantrone is a potent *topoisomerase II* inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity . Mitoxantrone also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-13062A

Daunorubicin 35+ Cited Publications Daunomycin; RP 13057; Rubidomycin	Infection Quinones Microorganisms Classification of Application Fields Anthraquinones Phenols Polyphenols Disease Research Fields Source Classification	Topoisomerase DNA/RNA Synthesis ADC Payload Autophagy Bacterial Antibiotic Apoptosis
Daunorubicin (Daunomycin) is a *topoisomerase II* inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-13502A

Mitoxantrone dihydrochloride 45+ Cited Publications Mitozantrone dihydrochloride; NSC 301739 dihydrochloride	Infection Quinones Classification of Application Fields Anthraquinones Endogenous metabolite Disease Research Fields Source Classification Cancer	Topoisomerase PKC Orthopoxvirus Apoptosis Endogenous Metabolite
Mitoxantrone dihydrochloride is a potent *topoisomerase II* inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-15142R

Doxorubicin hydrochloride (Standard) 5 Publications Verification Hydroxydaunorubicin hydrochloride (Standard); ADR (Standard)	Quinones Structural Classification Microorganisms Anthraquinones Source Classification	Reference Standards Topoisomerase ADC Payload AMPK Autophagy Apoptosis HIV HBV Mitophagy Antibiotic Bacterial Fluorescent Dye
Doxorubicin hydrochloride (Standard) is the analytical standard of Doxorubicin hydrochloride. This product is intended for research and analytical applications. Doxorubicin (Hydroxydaunorubicin) hydrochloride, a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin hydrochloride is a potent human *DNA topoisomerase* I and topoisomerase II** inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin hydrochloride reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin hydrochloride induces apoptosis and autophagy .

HY-15142A

Doxorubicin Hydroxydaunorubicin	Infection Quinones Structural Classification Microorganisms Classification of Application Fields Anthraquinones Phenols Polyphenols Disease Research Fields Source Classification	ADC Payload Antibiotic Bacterial Topoisomerase AMPK HIV Autophagy Mitophagy Apoptosis HBV Fluorescent Dye
Doxorubicin (Hydroxydaunorubicin), a cytotoxic anthracycline antibiotic, is an anti-cancer chemotherapy agent. Doxorubicin is a potent human *DNA topoisomerase* I and topoisomerase II** inhibitor with IC₅₀s of 0.8 μM and 2.67 μM, respectively. Doxorubicin reduces basal phosphorylation of AMPK and its downstream target acetyl-CoA carboxylase. Doxorubicin induces apoptosis and autophagy .

HY-N8473

Pericosine A (+)-Pericosine A	Natural Products Microorganisms Source Classification	Topoisomerase
Pericosine A ((+)-Pericosine A) is a topoisomerase II (Topoisomerase II) inhibitor that can be isolated from the Periconia byssoides strain. Pericosine A has significant antitumor activity in vitro and in vivo and can be used in cancer research. Pericosine A also inhibits the protein kinase epidermal growth factor receptor .

HY-13062R

Daunorubicin hydrochloride (Standard) Daunomycin hydrochloride (Standard); RP 13057 hydrochloride (Standard); Rubidomycin hydrochloride (Standard)	Quinones Structural Classification Microorganisms Anthraquinones Phenols Polyphenols Source Classification	Reference Standards Topoisomerase DNA/RNA Synthesis ADC Payload Bacterial Autophagy Apoptosis Antibiotic
Daunorubicin (hydrochloride) (Standard) is the analytical standard of Daunorubicin (hydrochloride). This product is intended for research and analytical applications. Daunorubicin (Daunomycin) hydrochloride is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin hydrochloride inhibits DNA and RNA synthesis. Daunorubicin hydrochloride is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin hydrochloride is also an anthracycline antibiotic. Daunorubicin hydrochloride can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-N15319

Eupolauridine Canangine	Alkaloids Other Alkaloids Cananga odorata Plants Annonaceae Source Classification	Topoisomerase Fungal
Eupolauridine (Canangine) is a selective DNA topoisomerase II inhibitor with IC₅₀ values of 20 μM for fungal topoisomerase I and 33 μM for human topoisomerase I. Eupolauridine exerts antifungal activity by inhibiting the catalytic activity of topoisomerase II and stabilizing its cleavage complex with DNA, leading to DNA damage. Eupolauridine is promising for research of fungal infectious diseases .

HY-13502B

Mitoxantrone diacetate Mitozantrone diacetate; NSC 301739 diacetate	Infection Quinones Classification of Application Fields Anthraquinones Endogenous metabolite Disease Research Fields Source Classification Cancer	Topoisomerase PKC Orthopoxvirus Apoptosis Endogenous Metabolite
Mitoxantrone diacetate is a potent *topoisomerase II* inhibitor. Mitoxantrone diacetate also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone diacetate induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone diacetate shows antitumor activity . Mitoxantrone diacetate also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-13502AR

Mitoxantrone dihydrochloride (Standard) Mitozantrone dihydrochloride (Standard); NSC 301739 dihydrochloride (Standard)	Quinones Structural Classification Anthraquinones Endogenous metabolite Source Classification	Reference Standards Topoisomerase PKC Orthopoxvirus Apoptosis Endogenous Metabolite
Mitoxantrone (dihydrochloride) (Standard) is the analytical standard of Mitoxantrone (dihydrochloride). This product is intended for research and analytical applications. Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC50 of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC50s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-13502R

Mitoxantrone (Standard) Mitozantrone (Standard); NSC 301739 (Standard)	Quinones Structural Classification Anthraquinones Endogenous metabolite Source Classification	Reference Standards Topoisomerase PKC Orthopoxvirus Apoptosis Endogenous Metabolite
Mitoxantrone (Standard) is the analytical standard of Mitoxantrone. This product is intended for research and analytical applications. Mitoxantrone is a potent *topoisomerase II* inhibitor. Mitoxantrone also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone shows antitumor activity . Mitoxantrone also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-N4329

Nidulalin A	Microorganisms Ketones, Aldehydes, Acids Source Classification	Topoisomerase
Nidulalin A is a DNA topoisomerase II inhibitor with an IC₅₀ of 2.2 μM. Nidulalin A has an IC₅₀ of 172 μM for *DNA topoisomerase* I**. Nidulalin A has certain cytotoxicity .

HY-N8250

cis-THSG	Structural Classification Simple Phenylpropanols Polygonaceae Phenylpropanoids Fallopia multiflora (Thunb.) Harald. Plants Source Classification	Topoisomerase PEPCK
cis-THSG is a selective and orally active DNA topoisomerase II inhibitor with no activity against DNA topoisomerase I. cis-THSG suppresses transcription of PEPCK. cis-THSG reduces blood glucose levels, ameliorates glucose intolerance, and alleviates insulin resistance in high fat diet-induced diabetic male CF-1 mice. cis-THSG can be used for the research of type 2 diabetes mellitus .

Cat. No.	Product Name	Chemical Structure

HY-13562AS

Banoxantrone-d12 dihydrochloride
Banoxantrone-d₁₂ (dihydrochloride) is the deuterium labeled Banoxantrone dihydrochloride. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.

HY-13562S

Banoxantrone-d12
Banoxantrone-d₁₂ is the deuterium labeled banoxantrone. Banoxantrone is a novel bioreductive agent that can be reduced to a stable, DNA-affinic compound AQ4, which is a potent topoisomerase II inhibitor.

HY-B0526S

Flumequine-13C3
Flumequine- ¹³C₃ is the ¹³C₃ labeled Flumequine. Flumequine (R-802) is a quinolone antibiotic, and acts as a topoisomerase II inhibitor, with an IC50 of 15 μM (3.92 μg/mL).

HY-W654130

Daunorubicin-13C,d3

Daunorubicin- ¹³C,d₃ is ¹³C and deuterium labeled Daunorubicin. Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

HY-13502S

Mitoxantrone-d8
Mitoxantrone-d₈ (mitozantrone-d₈) is the deuterium labeled Mitoxantrone. Mitoxantrone is a topoisomerase II inhibitor and also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM .

HY-13502AS

Mitoxantrone-d8 dihydrochloride

Mitoxantrone-d₈ dihydrochloride is deuterated labeled Mitoxantrone dihydrochloride (HY-13502A). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-13502AS1

Mitoxantrone-d8 hydrochloride

Mitoxantrone-d₈ (hydrochloride) (Mitozantrone-d₈ (hydrochloride)) is deuterium labeled Mitoxantrone (dihydrochloride). Mitoxantrone dihydrochloride is a potent topoisomerase II inhibitor. Mitoxantrone dihydrochloride also inhibits protein kinase C (PKC) activity with an IC₅₀ of 8.5 μM. Mitoxantrone dihydrochloride induces apoptosis of B-CLL (B-chronic lymphocytic leukaemia) cells. Mitoxantrone dihydrochloride shows antitumor activity . Mitoxantrone dihydrochloride also has anti-orthopoxvirus activity with EC₅₀s of 0.25 μM and and 0.8 μM for cowpox and monkeypox, respectively .

HY-13062AS

Daunorubicin-13C,d3 TFA

Daunorubicin- ¹³C,d₃ TFA (Daunomycin- ¹³C,d₃ TFA) is the deuterium and ¹³C-labeled Daunorubicin TFA. Daunorubicin (Daunomycin) is a topoisomerase II inhibitor with potent anti-tumor activity. Daunorubicin inhibits DNA and RNA synthesis. Daunorubicin is a cytotoxin that inhibits cancer cell viability and induces apoptosis and necrosis. Daunorubicin is also an anthracycline antibiotic. Daunorubicin can be used in the research of infection and variety of cancers, including leukemia, non-Hodgkin lymphomas, Ewing's sarcoma, Wilms' tumor .

Cat. No.	Product Name		Classification

HY-185372

Mitoxantrone hydrochloride liposome Liposomal mitoxantrone		Liposome
Mitoxantrone hydrochloride liposome is a liposome-encapsulated Mitoxantrone hydrochloride (HY-13502A) (a topoisomerase II inhibitor). Compared to regular Mitoxantrone hydrochloride, Mitoxantrone hydrochloride liposome enhances antitumor activity and prolongs drug circulation time in the body.

HY-185370

Doxorubicin liposome Pegylated liposomal doxorubicin; Liposomal doxorubicin; Doxorubicin hydrochloride liposome		Liposome
Doxorubicin liposome is a liposome-encapsulated form of doxorubicin hydrochloride (HY-15142). Doxorubicin hydrochloride, a cytotoxic anthracycline antibiotic, is a potent human DNA topoisomerase I and topoisomerase II inhibitor. Compared to traditional doxorubicin, liposome encapsulation reduces its cardiotoxicity and prolongs its circulation time, thus enabling it to effectively target tumor tissue.

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-16700G

PNU-159682	ADC Payload Topoisomerase	Cancer
PNU-159682 GMP is a GMP grade PNU-159682 (HY-16700). PNU-159682, a metabolite of the anthracycline Nemorubicin, is a highly potent DNA topoisomerase II inhibitor with excellent cytotoxicity. PNU-159682 acts as a more potent and tolerated ADC cytotoxin than Doxorubicin for ADC synthesis. PNU-159682 can be used in EDV-nanocell technology to overcome agent resistance.

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