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Cat. No.: HY-155645

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Topoisomerase II inhibitor 15

Topoisomerase II inhibitor 15 (compound 2g) is a Topoisomerase II inhibitor. Topoisomerase II inhibitor 15 potently is an apoptotic inducer with greater selectivity against head and neck tumors.

For research use only. We do not sell to patients.

CAS No.: 451516-79-3
Formula: C₁₅H₁₁Cl₂N₅
Molecular Weight:332.19

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Topoisomerase II inhibitor 15 Chemical Structure

CAS No.: 451516-79-3

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Topoisomerase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	4.8 μg/mL Compound: 2g	Growth inhibition of human HepG2 cell line assessed as reduction in cell viability by SRB colorimetric assay Growth inhibition of human HepG2 cell line assessed as reduction in cell viability by SRB colorimetric assay	[PMID: 37482023]
MDA-MB-231	IC₅₀	4 μg/mL Compound: 2g	Growth inhibition of human MDA-MB-231 cell line assessed as reduction in cell viability by SRB colorimetric assay Growth inhibition of human MDA-MB-231 cell line assessed as reduction in cell viability by SRB colorimetric assay	[PMID: 37482023]

In Vitro

Topoisomerase II inhibitor 15 (compound 2g) shows very strong activities against HNO97 with IC₅₀ values of 3 μg/mL. Topoisomerase II inhibitor 15 arrestes cell cycle progression at both the S and G2-M phases, as well as increased the early and late apoptosis phase ratios^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 451516-79-3
Molecular Weight 332.19
Formula C₁₅H₁₁Cl₂N₅
SMILES

ClC1=CC=C(C2N=C(N)N=C3NC4=C(N32)C=CC=C4)C=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Ahmed A Al-Karmalawy, et al. Novel fused imidazotriazines acting as promising top. II inhibitors and apoptotic inducers with greater selectivity against head and neck tumors: Design, synthesis, and biological assessments. Eur J Med Chem. 2023 Nov 5;259:115661. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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