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Cat. No.: HY-119892

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Batracylin

(Synonyms: NSC 320846; BAY-H 2049)

Batracylin (NSC320846) is a potent DNA Topoisomerases I and DNA Topoisomerases II inhibitor. Batracylin shows cytotoxicity and antiproliferative activity. Batracylin induces DNA breaks.

For research use only. We do not sell to patients.

CAS No.: 67199-66-0
Formula: C₁₅H₁₁N₃O
Molecular Weight:249.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Batracylin Chemical Structure

CAS No.: 67199-66-0

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- Clinical Trial
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Batracylin (NSC320846) is a potent DNA Topoisomerases I and DNA Topoisomerases II inhibitor. Batracylin shows cytotoxicity and antiproliferative activity. Batracylin induces DNA breaks^[1].

All Topoisomerase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	46.3 μM Compound: BAT; Batracylin	Cytotoxicity against human A549 cells after 120 hrs by MTT assay Cytotoxicity against human A549 cells after 120 hrs by MTT assay	[PMID: 26520842]
CCRF-CEM	IC₅₀	14 μM Compound: 1	Tested for the inhibitory activity against CCRF CEM T- cell leukemia cells Tested for the inhibitory activity against CCRF CEM T- cell leukemia cells	[PMID: 7932571]
HCT-116	IC₅₀	88.7 μM Compound: BAT; Batracylin	Cytotoxicity against human HCT116 cells after 120 hrs by MTT assay Cytotoxicity against human HCT116 cells after 120 hrs by MTT assay	[PMID: 26520842]
HL-60	IC₅₀	66.6 μM Compound: BAT; Batracylin	Cytotoxicity against human HL60 cells after 120 hrs by MTT assay Cytotoxicity against human HL60 cells after 120 hrs by MTT assay	[PMID: 26520842]
HT-29	IC₅₀	64.3 μM Compound: BAT; Batracylin	Cytotoxicity against human HT-29 cells after 120 hrs by MTT assay Cytotoxicity against human HT-29 cells after 120 hrs by MTT assay	[PMID: 26520842]
L1210	IC₅₀	>100 μM Compound: BAT; Batracylin	Cytotoxicity against mouse L1210 cells after 120 hrs by MTT assay Cytotoxicity against mouse L1210 cells after 120 hrs by MTT assay	[PMID: 26520842]
LNCaP	IC₅₀	90.2 μM Compound: BAT; Batracylin	Cytotoxicity against human LNCAP cells after 120 hrs by MTT assay Cytotoxicity against human LNCAP cells after 120 hrs by MTT assay	[PMID: 26520842]
MCF7	IC₅₀	>100 μM Compound: BAT; Batracylin	Cytotoxicity against human MCF7 cells after 120 hrs by MTT assay Cytotoxicity against human MCF7 cells after 120 hrs by MTT assay	[PMID: 26520842]
NIH3T3	IC₅₀	69.9 μM Compound: BAT; Batracylin	Cytotoxicity against mouse NIH/3T3 cells after 120 hrs by MTT assay Cytotoxicity against mouse NIH/3T3 cells after 120 hrs by MTT assay	[PMID: 26520842]
P388	IC₅₀	>100 μM Compound: BAT; Batracylin	Cytotoxicity against mouse P388 cells after 120 hrs by MTT assay Cytotoxicity against mouse P388 cells after 120 hrs by MTT assay	[PMID: 26520842]

In Vitro

Batracylin (0-300 µM; 6 h) shows cytotoxicity with an IC₅₀ value of 10.02 µM for HT29 cells^[1].
Batracylin (100, 300 µM; 3 h) induces protein-linked DNA breaks consistent with topoisomerase targeting^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 67199-66-0
Molecular Weight 249.27
Formula C₁₅H₁₁N₃O
SMILES

O=C1C2=C(C=CC=C2)C3=NC4=C(CN31)C=C(C=C4)N
Synonyms

NSC 320846; BAY-H 2049
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Rao VA, et al. Batracylin (NSC 320846), a dual inhibitor of DNA topoisomerases I and II induces histone gamma-H2AX as a biomarker of DNA damage. Cancer Res. 2007 Oct 15;67(20):9971-9. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- Clinical Trial
Chemical Information
Purity & Documentation
References

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Batracylin

All Topoisomerase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Batracylin Related Classifications

HY-119892 Related Classifications