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Cat. No.: HY-143281

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Topoisomerase II inhibitor 5

Topoisomerase II inhibitor 5 (Compound E24) is a DNA topoisomerase II inhibitor with anticancer activities.

For research use only. We do not sell to patients.

Formula: C₂₆H₂₇N₅O₄
Molecular Weight:473.52

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Topoisomerase II inhibitor 5 Chemical Structure

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Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Topoisomerase II inhibitor 5 (Compound E24) is a DNA topoisomerase II inhibitor with anticancer activities^[1].

IC₅₀ & Target

Topoisomerase II

All Topoisomerase Isoforms :

In Vitro

Topoisomerase II inhibitor 5 (Compound E24) (0-20 μM, 72 h) shows antiproliferative activities against cancer cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:

SW480, HCT116 and HeLa
Concentration:

0-20 μM
Incubation Time:

72 h
Result:

Showed antiproliferative activities with IC₅₀ values of 1.2 ± 0.3, 0.7 ± 0.05 and 1.2 ± 0.04 μM against SW480, HCT116 and HeLa cells, respectively.

Chemical Information

Molecular Weight 473.52
Formula C₂₆H₂₇N₅O₄
SMILES

O=C1C2=C(C([N+]([O-])=O)=CC=C2NC3=CC=C(CCN4CCN(C)CC4)C=C3)NC5=C1C=C(O)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen JN, et al. Structure-activity relationship of novel acridone derivatives as antiproliferative agents. Bioorg Med Chem. 2021 Jan 1;29:115868. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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