1. Cell Cycle/DNA Damage
  2. Topoisomerase
  3. Razoxane

Razoxane (Synonyms: ICRF 159)

Cat. No.: HY-119425
Handling Instructions

Razoxane (ICRF 159) is an antiangiogenic topoisomerase II inhibitor, can be used for the research of renal cell carcinoma (RCC).

For research use only. We do not sell to patients.

Razoxane Chemical Structure

Razoxane Chemical Structure

CAS No. : 21416-67-1

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Description

Razoxane (ICRF 159) is an antiangiogenic topoisomerase II inhibitor, can be used for the research of renal cell carcinoma (RCC)[1].

IC50 & Target[1]

Topoisomerase II

 

In Vitro

Razoxane (30 mg/kg; i.p.) exhibits antimetastatic effects in a rat osteosarcoma model.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Early treatment with Razoxane (30 mg/kg i.p. from day -2 to +14) shows a greater inhibition of pulmonary metastases than later treatment (30 mg/kg i.p. from day +14 to +28 after transplantation)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Sprague-Dawley rats[2]
Dosage: 30 mg/kg or 10 mg/kg per day
Administration: Intraperitoneally (i.p.) from 2 days before to 14 days after tumor transplantation
Result: Resulted in a dose-dependent prolongation of median survival time (83 or 48 days respectively, versus 38 days for the control group), but showed no influence on the growth of the primary tumor.
Molecular Weight

268.27

Formula

C11H16N4O4

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Razoxane
Cat. No.:
HY-119425
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