DNA topoisomerase II inhibitor 1 

DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase^[1].

DNA topoisomerase II inhibitor 1 (compound 8ed) (0-10 µM; 48 h) shows cytotoxic activity with IC₅₀s of 10.10, >10, 0.59, 4.20, >10, >10, 8.41 µM for HT-29, MDA-MB-231, MG-63, U87MG, PC3, HeLa, Vero cells, respectively^[1].
DNA topoisomerase II inhibitor 1 (0.5, 2 µM; 24 h) induces apoptosis and cell cycle arrest at sub G1 phase^[1].
DNA topoisomerase II inhibitor 1 (0.5, 2 µM) increases the generation of reactive oxygen species (ROS)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

496.58

C₂₈H₂₄N₄O₃S

2459950-15-1

O=C(N1CCN(S(C2=CC=CC=C2)(=O)=O)CC1)C3=CC4=C(C(C5=CC=CC=C5)=N3)NC6=C4C=CC=C6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lakshmi Manasa K, et al. Design and synthesis of β-carboline linked aryl sulfonyl piperazine derivatives: DNA topoisomerase II inhibition with DNA binding and apoptosis inducing ability. Bioorg Chem. 2020 Aug;101:103983.  [Content Brief]