1. Cell Cycle/DNA Damage
  2. Topoisomerase
  3. Topoisomerase II inhibitor 12

Topoisomerase II inhibitor 12 (Compound 8c) is a topoisomerase II (topo II) inhibitor, working as a DNA non-intercalator. Topoisomerase II inhibitor 12 shows antineoplastic activity.

For research use only. We do not sell to patients.

Topoisomerase II inhibitor 12 Chemical Structure

Topoisomerase II inhibitor 12 Chemical Structure

CAS No. : 2304527-20-4

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Description

Topoisomerase II inhibitor 12 (Compound 8c) is a topoisomerase II (topo II) inhibitor, working as a DNA non-intercalator. Topoisomerase II inhibitor 12 shows antineoplastic activity[1].

In Vitro

Topoisomerase II inhibitor 12 (Compound 8c) shows anti-proliferative activities with IC50 values of 8.80 ± 0.12, 7.13 ± 0.20, 6.56 ± 0.15, 10.99 ± 0.23, 10.71 ± 0.03 and 13.27 ± 0.32 μM against HepG2, HCT116, MDA-MB-231, Hela, K562 and PDLSC cells, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

649.95

Formula

C40H63N3O4

CAS No.
SMILES

CCCCCCCCCCCCOC1=C(C(C2=C(C3=O)C=CC=C2)=O)C3=C(C=C1)OCCCCNCCCNCCCCNCCC

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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References
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Topoisomerase II inhibitor 12 Related Classifications

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Topoisomerase II inhibitor 12
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HY-147877
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