Topoisomerase II inhibitor 3
Topoisomerase II inhibitor 3 (Compound 6 h ) is a acridone derivatives, as well as a Type II DNA topoisomerase (topo II) inhibitor , as a topo IIα/β inhibitor with the value of IC50 is 0.17 μM for topo IIα and the value of IC50 is 0.23 μM for topo IIβ subtypes, caused obvious DNA damage, and induced apoptosis by triggering the loss of mitochondrial membrane potential.
For research use only. We do not sell to patients.
- CAS No.: 99140-25-7
- Formula: C18H20N4O4
- Molecular Weight:356.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 0.17 μM (topo IIα); IC50: 0.23 μM (topo IIβ)[1]
Topoisomerase II inhibitor 3 (Compound 6 h ) has function as a strong topo IIα/β inhibitor, causeS obvious DNA damage, and induces apoptosis by triggering the loss of mitochondrial membrane potential.
Topoisomerase II inhibitor 3 (Compound 6 h ) is a topo IIα/β dual inhibitor with the value of IC50 is 0.17 μM for topo IIα and the value of IC50 is 0.23 μM for topo IIβ subtypesl.
Topoisomerase II inhibitor 3 (Compound 6 h ) also can induce the formation of DSBs in a does-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human breast cancer MDA-MB-231 cells; human lung cancer A549; human acute myelogenous leukemia KG1 cells; rat myocardial H9C2 cells
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Concentration:100 μM
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Incubation Time:12 h
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Result:Exerted the most potent anti-proliferative activity in MDA-MB-231 cells (IC50: 0.42 μM), A549 cells (IC50: 1.10 μM), KG1 cells (IC50: 0.15 μM) and H9C2 cells (IC50 >20 μM).
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Cell Line:MDA-MB-231 cells
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Concentration:0.5-10 μM
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Incubation Time:24 h
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Result:Caused obvious loss of mitochondrial membrane potential (MMP) in MDA-MB-231 cells.
Chemical Information
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CAS No. 99140-25-7
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Molecular Weight 356.38
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Formula C18H20N4O4
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SMILES
O=C1C2=C(C([N+]([O-])=O)=CC=C2NCCCN(C)C)NC3=C1C=C(O)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Topoisomerase II inhibitor 3 Related Classifications
HY-143279 Related Classifications
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