2. Cell Cycle/DNA Damage
  3. Topoisomerase
  4. Topoisomerase II inhibitor 13

Topoisomerase II inhibitor 13 is a topoisomerase II (Topo II) inhibitor. Topoisomerase II inhibitor 13 shows antiproliferative activity against several cancer cells. Topoisomerase II inhibitor 13 induces cancer cells apoptosis.

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Topoisomerase II inhibitor 13 Chemical Structure

Topoisomerase II inhibitor 13 Chemical Structure

CAS No. : 451515-89-2

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Topoisomerase II inhibitor 13 Related Antibodies

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Description

Topoisomerase II inhibitor 13 is a topoisomerase II (Topo II) inhibitor. Topoisomerase II inhibitor 13 shows antiproliferative activity against several cancer cells. Topoisomerase II inhibitor 13 induces cancer cells apoptosis[1].

IC50 & Target[1]

Topoisomerase II

 

In Vitro

Topoisomerase II inhibitor 13 (compound 3m) (20 μM, 50 μM) exerts strong inhibitory effect at 20 μM, and almost completely inhibits Topo II activity[1].
Topoisomerase II inhibitor 13 inhibits cancer cells proliferation with IC50s of 25.85 μM (MDA-MB-231), 1.82 μM (A549), 10.38 μM (K562), 1.73 μM (Raji), 1.23 μM (HL-60), and 0.87 μM (HL-60/MX2), respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Topoisomerase II inhibitor 13 Related Antibodies
Molecular Weight

413.48

Formula

C22H23N9
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

N#CC1=NC2=C(N(CCCN(CC)CC)C(N)=C2C3=NC4=C(N3)C=CC=C4)N=C1C#N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (30.23 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4185 mL 12.0925 mL 24.1850 mL
5 mM 0.4837 mL 2.4185 mL 4.8370 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4185 mL 12.0925 mL 24.1850 mL 60.4624 mL
5 mM 0.4837 mL 2.4185 mL 4.8370 mL 12.0925 mL
10 mM 0.2418 mL 1.2092 mL 2.4185 mL 6.0462 mL
15 mM 0.1612 mL 0.8062 mL 1.6123 mL 4.0308 mL
20 mM 0.1209 mL 0.6046 mL 1.2092 mL 3.0231 mL
25 mM 0.0967 mL 0.4837 mL 0.9674 mL 2.4185 mL
30 mM 0.0806 mL 0.4031 mL 0.8062 mL 2.0154 mL
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Topoisomerase II inhibitor 13 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topoisomerase II inhibitor 13451515-89-2Topoisomerase II inhibitor13Topoisomerase II inhibitor-13TopoisomeraseInhibitorinhibitorinhibit

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