Topoisomerase II inhibitor 13
Based on 1 Customer Validation
Topoisomerase II inhibitor 13 is a topoisomerase II (Topo II) inhibitor. Topoisomerase II inhibitor 13 shows antiproliferative activity against several cancer cells. Topoisomerase II inhibitor 13 induces cancer cells apoptosis.
For research use only. We do not sell to patients.
- Purity: 98.07%
- CAS No.: 451515-89-2
- Formula: C22H23N9
- Molecular Weight:413.48
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
All Topoisomerase Isoforms
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Biological Activity
Description
IC50 & Target
[1]|
Topoisomerase II |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
25.33 μM
Compound: 3n
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Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
Antiproliferative activity against human A549 cells after 48 hrs by MTT assay
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[PMID: 26649766] |
| HEK293 | IC50 |
7.87 μM
Compound: 3n
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Cytotoxicity against HEK293 cells after 48 hrs by MTT assay
Cytotoxicity against HEK293 cells after 48 hrs by MTT assay
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[PMID: 26649766] |
| HeLa | IC50 |
3.15 μM
Compound: 3n
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Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
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[PMID: 26649766] |
| HL-60 | IC50 |
>0.73 μM
Compound: 3n
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Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay
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[PMID: 26649766] |
| HL60/MX2 | IC50 |
1.82 μM
Compound: 3n
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Antiproliferative activity against human HL60/MX2 cells after 48 hrs by MTT assay
Antiproliferative activity against human HL60/MX2 cells after 48 hrs by MTT assay
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[PMID: 26649766] |
| K562 | IC50 |
1.8 μM
Compound: 3n
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Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
Antiproliferative activity against human K562 cells after 48 hrs by MTT assay
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[PMID: 26649766] |
| Raji | IC50 |
1.87 μM
Compound: 3n
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Antiproliferative activity against human Raji cells after 48 hrs by MTT assay
Antiproliferative activity against human Raji cells after 48 hrs by MTT assay
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[PMID: 26649766] |
In Vitro
Topoisomerase II inhibitor 13 (compound 3m) (20 μM, 50 μM) exerts strong inhibitory effect at 20 μM, and almost completely inhibits Topo II activity[1].
Topoisomerase II inhibitor 13 inhibits cancer cells proliferation with IC50s of 25.85 μM (MDA-MB-231), 1.82 μM (A549), 10.38 μM (K562), 1.73 μM (Raji), 1.23 μM (HL-60), and 0.87 μM (HL-60/MX2), respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 451515-89-2
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Appearance Solid
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Molecular Weight 413.48
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Formula C22H23N9
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Color Light yellow to yellow
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SMILES
N#CC1=NC2=C(N(CCCN(CC)CC)C(N)=C2C3=NC4=C(N3)C=CC=C4)N=C1C#N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 12.5 mg/mL (30.23 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4185 mL | 12.0925 mL | 24.1850 mL | 60.4624 mL |
| 5 mM | 0.4837 mL | 2.4185 mL | 4.8370 mL | 12.0925 mL | |
| 10 mM | 0.2418 mL | 1.2092 mL | 2.4185 mL | 6.0462 mL | |
| 15 mM | 0.1612 mL | 0.8062 mL | 1.6123 mL | 4.0308 mL | |
| 20 mM | 0.1209 mL | 0.6046 mL | 1.2092 mL | 3.0231 mL | |
| 25 mM | 0.0967 mL | 0.4837 mL | 0.9674 mL | 2.4185 mL | |
| 30 mM | 0.0806 mL | 0.4031 mL | 0.8062 mL | 2.0154 mL |
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