Topoisomerase II inhibitor 13

Name: Topoisomerase II inhibitor 13
Brand: MedChemExpress
SKU: HY-153401
Rating: 4.5 (0 reviews)

製品番号: HY-153401 純度: 98.07%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

Topoisomerase II inhibitor 13 is a topoisomerase II (Topo II) inhibitor. Topoisomerase II inhibitor 13 shows antiproliferative activity against several cancer cells. Topoisomerase II inhibitor 13 induces cancer cells apoptosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Topoisomerase II inhibitor 13 構造式

CAS 番号 : 451515-89-2

容量	価格（税別）	在庫状況	数量
5 mg	$100	在庫あり	Estimated Time of Arrival: December 31
10 mg	$160	在庫あり	Estimated Time of Arrival: December 31
50 mg		お問い合わせ
100 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 0 publication(s) in Google Scholar

Topoisomerase アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示

Topoisomerase Topo I Topo II DNA gyrase

生物活性
純度とドキュメンテーション
参考文献
カスタマーレビュー

製品説明

IC₅₀ & Target^[1]

Topoisomerase II

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	25.33 μM Compound: 3n	Antiproliferative activity against human A549 cells after 48 hrs by MTT assay Antiproliferative activity against human A549 cells after 48 hrs by MTT assay	[PMID: 26649766]
HEK293	IC₅₀	7.87 μM Compound: 3n	Cytotoxicity against HEK293 cells after 48 hrs by MTT assay Cytotoxicity against HEK293 cells after 48 hrs by MTT assay	[PMID: 26649766]
HeLa	IC₅₀	3.15 μM Compound: 3n	Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay	[PMID: 26649766]
HL-60	IC₅₀	>0.73 μM Compound: 3n	Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay Antiproliferative activity against human HL60 cells after 48 hrs by MTT assay	[PMID: 26649766]
HL60/MX2	IC₅₀	1.82 μM Compound: 3n	Antiproliferative activity against human HL60/MX2 cells after 48 hrs by MTT assay Antiproliferative activity against human HL60/MX2 cells after 48 hrs by MTT assay	[PMID: 26649766]
K562	IC₅₀	1.8 μM Compound: 3n	Antiproliferative activity against human K562 cells after 48 hrs by MTT assay Antiproliferative activity against human K562 cells after 48 hrs by MTT assay	[PMID: 26649766]
Raji	IC₅₀	1.87 μM Compound: 3n	Antiproliferative activity against human Raji cells after 48 hrs by MTT assay Antiproliferative activity against human Raji cells after 48 hrs by MTT assay	[PMID: 26649766]

体外実験

Topoisomerase II inhibitor 13 (compound 3m) (20 μM, 50 μM) exerts strong inhibitory effect at 20 μM, and almost completely inhibits Topo II activity^[1].
Topoisomerase II inhibitor 13 inhibits cancer cells proliferation with IC₅₀s of 25.85 μM (MDA-MB-231), 1.82 μM (A549), 10.38 μM (K562), 1.73 μM (Raji), 1.23 μM (HL-60), and 0.87 μM (HL-60/MX2), respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

413.48

分子式

C₂₂H₂₃N₉

CAS 番号

451515-89-2

Appearance

Solid

Color

Light yellow to yellow

SMILES

N#CC1=NC2=C(N(CCCN(CC)CC)C(N)=C2C3=NC4=C(N3)C=CC=C4)N=C1C#N

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 12.5 mg/mL (30.23 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4185 mL	12.0925 mL	24.1850 mL
5 mM	0.4837 mL	2.4185 mL	4.8370 mL
10 mM	0.2418 mL	1.2092 mL	2.4185 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.07%

Select Batch:

データシート (276 KB) SDS (393 KB)

COA (255 KB) HNMR (286 KB) LCMS (330 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Li P H, et al. Synthesis and mechanism studies of 1, 3-benzoazolyl substituted pyrrolo [2, 3-b] pyrazine derivatives as nonintercalative topoisomerase II catalytic inhibitors. Journal of Medicinal Chemistry, 2016, 59(1): 238-252.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4185 mL	12.0925 mL	24.1850 mL	60.4624 mL
	5 mM	0.4837 mL	2.4185 mL	4.8370 mL	12.0925 mL
	10 mM	0.2418 mL	1.2092 mL	2.4185 mL	6.0462 mL
	15 mM	0.1612 mL	0.8062 mL	1.6123 mL	4.0308 mL
	20 mM	0.1209 mL	0.6046 mL	1.2092 mL	3.0231 mL
	25 mM	0.0967 mL	0.4837 mL	0.9674 mL	2.4185 mL
	30 mM	0.0806 mL	0.4031 mL	0.8062 mL	2.0154 mL