Topoisomerase II inhibitor 1
Based on 1 Customer Validation
Topoisomerase II inhibitor 1 (compound 89) is a highly efficient and selective topoisomerase IIα inhibitor.
For research use only. We do not sell to patients.
- Purity : 99.9%
- CAS No.: 2375613-31-1
- Formula: C24H16ClNO2
- Molecular Weight:385.84
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
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Help & FAQs
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Biological Activity
Description
IC50 & Target
Topoisomerase IIα[1]
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| DU-145 | IC50 |
0.072 μM
Compound: 89
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Antiproliferative activity against human DU145 cells measured after 72 hrs by EZ-Cytox assay
Antiproliferative activity against human DU145 cells measured after 72 hrs by EZ-Cytox assay
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[PMID: 31398033] |
| HCC70 | IC50 |
2.083 μM
Compound: 89
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Antiproliferative activity against human HCC70 cells measured after 72 hrs by Ez-cytox assay
Antiproliferative activity against human HCC70 cells measured after 72 hrs by Ez-cytox assay
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[PMID: 31398033] |
| HCT-15 | IC50 |
0.014 μM
Compound: 89
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Antiproliferative activity against human HCT15 cells measured after 72 hrs by EZ-Cytox assay
Antiproliferative activity against human HCT15 cells measured after 72 hrs by EZ-Cytox assay
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[PMID: 31398033] |
| HeLa | IC50 |
2.46 μM
Compound: 89
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Antiproliferative activity against human HeLa cells measured after 72 hrs by EZ-Cytox assay
Antiproliferative activity against human HeLa cells measured after 72 hrs by EZ-Cytox assay
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[PMID: 31398033] |
| MDA-MB-231 | IC50 |
2.7 μM
Compound: 89
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Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by Ez-cytox assay
Antiproliferative activity against human MDA-MB-231 cells measured after 72 hrs by Ez-cytox assay
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[PMID: 31398033] |
| MDA-MB-436 | IC50 |
2.64 μM
Compound: 89
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Antiproliferative activity against human MDA-MB-436 cells measured after 72 hrs by Ez-cytox assay
Antiproliferative activity against human MDA-MB-436 cells measured after 72 hrs by Ez-cytox assay
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[PMID: 31398033] |
| T47D | IC50 |
0.00267 μM
Compound: 89
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Antiproliferative activity against human T47D cells measured after 72 hrs by EZ-Cytox assay
Antiproliferative activity against human T47D cells measured after 72 hrs by EZ-Cytox assay
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[PMID: 31398033] |
Chemical Information
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CAS No. 2375613-31-1
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Appearance Solid
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Molecular Weight 385.84
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Formula C24H16ClNO2
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Color White to off-white
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SMILES
OC1=CC=CC2=C1CC3=C(C4=CC=C(O)C=C4)C=C(C5=CC=CC=C5Cl)N=C32
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Purity & Documentation
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Data Sheet (249 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Topoisomerase II inhibitor 1 Related Classifications
HY-126333 Related Classifications
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