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Cat. No.: HY-120679A

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XK469 sodium

(Synonyms: NSC 697887 sodium)

XK469 (NSC 697887) sodium is a quinoxaline-based topoisomerase II inhibitor. XK469 sodium exhibits antiproliferative activity against neuroblastoma cells. XK469 sodium can be used in the research of neuroblastoma.

For research use only. We do not sell to patients.

CAS No.: 157434-99-6
Formula: C₁₇H₁₂ClN₂NaO₄
Molecular Weight:366.73

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

XK469 sodium Chemical Structure

CAS No.: 157434-99-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Topoisomerase II

All Topoisomerase Isoforms :

In Vitro

XK469 (72 h) sodium inhibits the proliferation of SK-N-SH and IMR-3 neuroblastoma cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

SK-N-SH cells; IMR-32 cells
Concentration:

/
Incubation Time:

72 h
Result:

Had IC₅₀ values of 4.6 μM and 13.0 μM for SK-N-SH and IMR-32.

Chemical Information

CAS No. 157434-99-6
Molecular Weight 366.73
Formula C₁₇H₁₂ClN₂NaO₄
SMILES

O=C(C(C)OC1=CC=C(C=C1)OC2=NC3=CC(Cl)=CC=C3N=C2)O[Na]
Synonyms

NSC 697887 sodium
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Montana M, et al. Synthesis of new quinoxalines containing an oxirane ring by the TDAE strategy and in vitro evaluation in neuroblastoma cell lines. Molecules. 2014;19(9):14987-14998. Published 2014 Sep 18. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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XK469 sodium

All Topoisomerase Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

XK469 sodium Related Classifications

HY-120679A Related Classifications