Synthesis of new quinoxalines containing an oxirane ring by the TDAE strategy and in vitro evaluation in neuroblastoma cell lines

  • Molecules. 2014 Sep 18;19(9):14987-98. doi: 10.3390/molecules190914987.
Marc Montana  1 ,  Florian Correard  2 ,  Omar Khoumeri  3 ,  Marie-Anne Esteve  4 ,  Thierry Terme  5 ,  Patrice Vanelle  6
Affiliations
  • 1. Aix-Marseille Université, CNRS, Institut de Chimie Radicalaire ICR, UMR 7273, Laboratoire de Pharmaco-Chimie Radicalaire, Marseille 13385, France. [email protected].
  • 2. Aix-Marseille Université, INSERM, CRO2, UMR_S911, Marseille 13385, France. [email protected].
  • 3. Aix-Marseille Université, CNRS, Institut de Chimie Radicalaire ICR, UMR 7273, Laboratoire de Pharmaco-Chimie Radicalaire, Marseille 13385, France. [email protected].
  • 4. Aix-Marseille Université, INSERM, CRO2, UMR_S911, Marseille 13385, France. [email protected].
  • 5. Aix-Marseille Université, CNRS, Institut de Chimie Radicalaire ICR, UMR 7273, Laboratoire de Pharmaco-Chimie Radicalaire, Marseille 13385, France. [email protected].
  • 6. Aix-Marseille Université, CNRS, Institut de Chimie Radicalaire ICR, UMR 7273, Laboratoire de Pharmaco-Chimie Radicalaire, Marseille 13385, France. [email protected].
PMID: 25237753 DOI: 10.3390/molecules190914987
Abstract

Neuroblastoma is an aggressive pediatric malignancy with significant chemotherapeutic resistance. In order to obtain new compounds active on neuroblastoma cell lines, we investigated the reactivity of carbanion formed via TDAE in quinoxaline series. The new synthesized compounds were tested for their anti-proliferative activity on two neuroblastoma cell lines, and seven oxirane derivatives obtained interesting activities.

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