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Cat. No.: HY-146316

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Topoisomerase II inhibitor 6

Topoisomerase II inhibitor 6 (Compound 5), a tryptanthrin derivative, is a potent and selective inhibitor of topoisomerase II. Topoisomerase II inhibitor 6 exhibits antiproliferative activity on different tumor cell lines. Topoisomerase II inhibitor 6 blocks the cell cycle of CCRF-CEM in the G2 phase and induces DNA DSB. Topoisomerase II inhibitor 6 has the potential for the research of cancer diseases.

For research use only. We do not sell to patients.

CAS No.: 2987586-62-7
Formula: C₁₉H₁₈N₄O₂
Molecular Weight:334.37

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

Topoisomerase II inhibitor 6 Chemical Structure

CAS No.: 2987586-62-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

All Topoisomerase Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
CCRF-CEM	GI₅₀	1.36 μM Compound: 5	Antiproliferative activity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method Antiproliferative activity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method	[PMID: 32712536]
CCRF-CEM	IC₅₀	8.26 μM Compound: 5	Antiproliferative activity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method Antiproliferative activity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method	[PMID: 32712536]
CEM/C2	IC₅₀	9.16 μM Compound: 5	Antiproliferative activity against human CEM/C2 cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method Antiproliferative activity against human CEM/C2 cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method	[PMID: 32712536]
DLD-1	IC₅₀	7.13 μM Compound: 5	Antiproliferative activity against human DLD-1 cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method Antiproliferative activity against human DLD-1 cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method	[PMID: 32712536]
HL-60	IC₅₀	11.46 μM Compound: 5	Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method Antiproliferative activity against human HL-60 cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method	[PMID: 32712536]
HT-29	IC₅₀	9.4 μM Compound: 5	Antiproliferative activity against human HT29 cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method Antiproliferative activity against human HT29 cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method	[PMID: 32712536]
Jurkat	IC₅₀	18.2 μM Compound: 5	Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method Antiproliferative activity against human Jurkat cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method	[PMID: 32712536]
MCF7	IC₅₀	30.48 μM Compound: 5	Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability after 72 hrs by eosin exclusion dye based light microscopic method	[PMID: 32712536]

Chemical Information

CAS No. 2987586-62-7
Molecular Weight 334.37
Formula C₁₉H₁₈N₄O₂
SMILES

O=C1C2=NC3=C(C(N2C4=C1C(NCCN(C)C)=CC=C4)=O)C=CC=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Catanzaro E, et al. Targeting topoisomerase II with trypthantrin derivatives: Discovery of 7-((2-(dimethylamino)ethyl)amino)indolo[2,1-b]quinazoline-6,12-dione as an antiproliferative agent and to treat cancer. Eur J Med Chem. 2020 Sep 15;202:112504. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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