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Results for "

leukemia p388

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Deaminase (1) Aminopeptidase (1) Antibiotic (31) Apoptosis (8) Autophagy (5) Bacterial (37) CDK (1) Cytochrome P450 (2) DNA Alkylator/Crosslinker (1) DNA/RNA Synthesis (2) Drug Derivative (6) Endogenous Metabolite (3) Environmental Pollutants (1) Estrogen Receptor/ERR (1) Farnesyl Transferase (1) Fungal (8) HIV (4) HSP (1) MetAP (1) Mitophagy (2) Opioid Receptor (1) P-glycoprotein (3) Parasite (2) PKC (1) Potassium Channel (2) Reference Standards (4) Reverse Transcriptase (1) Topoisomerase (7)
By Research Areas:	Cancer (80) Cardiovascular Disease (2) Endocrinology (1) Infection (53) Neurological Disease (5)

By Targets:

Adenosine Deaminase (1)

Aminopeptidase (1)

Antibiotic (31)

Apoptosis (8)

Autophagy (5)

Bacterial (37)

CDK (1)

Cytochrome P450 (2)

DNA Alkylator/Crosslinker (1)

DNA/RNA Synthesis (2)

Drug Derivative (6)

Endogenous Metabolite (3)

Environmental Pollutants (1)

Estrogen Receptor/ERR (1)

Farnesyl Transferase (1)

Fungal (8)

HIV (4)

HSP (1)

MetAP (1)

Mitophagy (2)

Opioid Receptor (1)

P-glycoprotein (3)

Parasite (2)

PKC (1)

Potassium Channel (2)

Reference Standards (4)

Reverse Transcriptase (1)

Topoisomerase (7)

By Research Areas:

Cancer (80)

Cardiovascular Disease (2)

Endocrinology (1)

Infection (53)

Neurological Disease (5)

Inhibitors & Agonists

Peptides

Natural
Products

Targets Recommended: BMI1

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13629

Etoposide Maximum Cited Publications 174 Publications Verification VP-16; VP-16-213	Topoisomerase Autophagy Mitophagy Bacterial Apoptosis Antibiotic	Infection Cancer
Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-13630

Etoposide phosphate Maximum Cited Publications 174 Publications Verification BMY-40481	Topoisomerase Bacterial Autophagy Apoptosis	Infection Neurological Disease Cancer
Etoposide phosphate (BMY-40481) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate is the phosphate ester proagent of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate induces cell cycle arrest, apoptosis, and autophagy.

HY-15255

Zosuquidar 15+ Cited Publications RS 33295-198; LY-335979	P-glycoprotein	Cancer
Zosuquidar (LY335979) is a P-glycoprotein (P-gp) inhibitor (K_i=59 nM). Zosuquidar shows anti-tumor activities, and can be used in acute myelogenous leukemia (AML) research .

HY-N3308

Medicarpin 2 Publications Verification	Apoptosis	Cancer
Medicarpin is a flavonoid isolated from Medicago sativa. Medicarpin induces apoptosis and overcome multidrug resistance in leukemia P388 cells by modulating P-gp-mediated efflux of agents .

HY-50671

Zosuquidar trihydrochloride 15+ Cited Publications RS 33295-198 trihydrochloride; LY-335979 trihydrochloride	P-glycoprotein	Cancer
Zosuquidar (LY335979) trihydrochloride is a P-glycoprotein (P-gp) inhibitor (K_i=59 nM). Zosuquidar trihydrochloride shows anti-tumor activities, and can be used in acute myelogenous leukemia (AML) research .

HY-B1751B

Quinine sulfate 5+ Cited Publications	Parasite Potassium Channel Cytochrome P450	Infection Cardiovascular Disease Cancer
Quinidine sulfate is an antiarrhythmic agent. Quinidine sulfate is a potent, orally active, selective cytochrome P450db inhibitor. Quinidine sulfate is also a K ⁺ channel blocker with an IC₅₀ of 19.9 μM. Quinidine sulfate can be used for malaria research .

HY-N0128

Sclareol 3 Publications Verification	Environmental Pollutants Apoptosis	Cancer
Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB) cells and human leukemia cell lines. Sclareol induces cell apoptosis .

HY-120504

N-Acetyltyramine 1 Publications Verification	Bacterial	Infection Cancer
N-Acetyltyramine is a quorum-sensing inhibitor (QSI) compound produced by V. alginolyticus M3-10. N-Acetyltyramine is capable of inhibiting the QS of C. violaceum ATCC 12472. N-acetyltyramine reverses resistance in Doxorubicin-resistant leukemia P388 cells .

HY-N2571

Corydine	Reverse Transcriptase HIV Opioid Receptor	Infection Neurological Disease Cancer
Corydine is a HIV-1 reverse transcriptase inhibitor and μ-opioid receptor (MOR) agonist, with an IC₅₀ of 356.7 μg/mL against HIV-1 reverse transcriptase, an EC₅₀ of 0.51 μM for MOR, and a K_i of 2.82 μM for MOR. Corydine produces antinociceptive effects by inhibiting acetic acid-induced writhing behavior in a MOR-dependent manner. Corydine inhibits the proliferation of cancer cells, mitogen-stimulated lymphocytes and IL-2-dependent cells. Corydine can be used in studies related to human immunodeficiency virus infection, visceral pain, leukemia, melanoma, bladder cancer and colon adenocarcinoma .

HY-13629R

Etoposide (Standard) 1 Publications Verification VP-16 (Standard); VP-16-213 (Standard)	Reference Standards Topoisomerase Autophagy Mitophagy Bacterial Apoptosis Antibiotic	Infection Cancer
Etoposide (Standard) is the analytical standard of Etoposide. This product is intended for research and analytical applications. Etoposide (VP-16; VP-16-213) is an anti-cancer chemotherapy agent. Etoposide inhibits topoisomerase II, thus stopping DNA replication. Etoposide induces cell cycle arrest, apoptosis and autophagy .

HY-B1127

Betamipron N-Benzoyl-β-alanine	Antibiotic Bacterial	Infection Endocrinology
Betamipron (N-benzoyl-β-alanine) is a carbapenem β-lactam antibiotic with antibacterial activity against most Gram-positive and Gram-negative aerobic and anaerobic bacteria. Betamipron can target and inhibit renal organic anion transporters, alleviate renal injury caused by Cisplatin (HY-17394), without interfering with the biological activity of cisplatin. Betamipron is often used in combination with panipenem, which can attenuate the renal effects induced by panipenem and slightly promote the proliferation of Clostridium difficile in the cecum. Betamipron can be used in studies related to renal injury and bacterial infection .

HY-103159

1-Deazaadenosine	Adenosine Deaminase	Cancer
1-Deazaadenosine is a potent Adenosine deaminase (ADA) inhibitor with a K_i value of 0.66 μM. 1-Deazaadenosine exhibits anti-cancer activities in vitro and has the potential to be a chemotherapy agent for lymphoproliferative disorders .

HY-108603

Bryostatin 2 (+)-Bryostatin 2	PKC	Cancer
Bryostatin 2 ((+)-Bryostatin 2) is a 20-membered ring lactone that can be found in Bryozoan Eugufa neritina L. Bryostatin 2 has the potential for the research of P-388 lymphocytic leukemia .

HY-103653

CKD-731	MetAP	Cardiovascular Disease Cancer
CKD-731 is a Fumagillin (HY-B0751) analogue. CKD-731 inhibits the proliferation of calf pulmonary artery endothelial cells (CPAE), lymphoma EL-4 cells and murine leukemia P388D1 cells. CKD-731 exerts the effect of inhibiting MetAP-2 activity and blocking angiogenesis. CKD-731 can be used for the research of anti-angiogenesis-related cancer .

HY-12458

Pyrindamycin A	DNA/RNA Synthesis	Infection Cancer
Pyrindamycin A is an antibiotic that inhibits DNA synthesis. Pyrindamycin A shows antitumor activities against murine leukemia, exhibits stronger cytotoxic activities towards murine and human tumor cell lines and especially towards doxorubicin-resistant cells, inhibits P388 and P388/ADR cells with the same IC₅₀ of 3.9 μg/ml .

HY-125037

Diptoindonesin G	Estrogen Receptor/ERR HSP	Cancer
Diptoindonesin G is a 2-arylbenzofuran derivative and a modulator of estrogen receptor and HSP90 middle domain. Diptoindonesin G exhibits strong cytotoxicity against mouse leukemia P-388 cells with an IC₅₀ of 13.2 μM. Diptoindonesin G has antitumor activity and can be used in the research of tumors such as breast cancer .

HY-121123

Adamantanine 2-Aminoadamantane-2-carboxylic acid	Aminopeptidase	Cancer
Adamantanine (2-Aminoadamantane-2-carboxylic acid) inhibits the transport of methionine (K_i is 0.76 mM) and leucine into Ehrlich ascites carcinoma cells. Adamantanine inhibits proliferation of P388 lymphocytic leukemia cells with an IC₅₀ of >1 mM. Adamantanine inhibits the leucine aminopeptidase with an I/S_0.5 of 10.5 .

HY-129752

Piperafizine B	Antibiotic	Cancer
Piperafizine B exhibits slightly cytotoxicity in moser cells, P388 cells and Vincristine (VCR) (HY-N0488)-resistant P388 cells (IC₅₀s is 23.8, 22.6 and 23.7 μg/mL, respectively). Piperafizine B exhibits synergistic effects with Vincristine, enhances the VCR-induced cytotoxicity and ameliorates the leukemia in mouse model .

HY-114648

AJI-9561	Bacterial	Infection Cancer
AJI-9561 is a benzoxazole derivative produced by Streptomyces sp. AJI-9561 exhibits cytotoxicity and antibacterial activity. AJI-9561 inhibits the proliferation of Jurkat T cells and mouse P388 leukemia cells, with its IC₅₀ being 0.88 and 1.63 μM respectively. AJI-9561 can be used for research on anti-cancer and antibacterial properties .

HY-13630A

Etoposide phosphate disodium BMY-40481 disodium	Topoisomerase Autophagy Apoptosis	Neurological Disease Cancer
Etoposide phosphate disodium (BMY-40481 disodium) is a potent anti-cancer chemotherapy agent and a selective topoisomerase II inhibitor to prevent re-ligation of DNA strands. Etoposide phosphate disodium is the phosphate ester proagent of etoposide and is considered as active equivalent to Etoposide. Etoposide phosphate disodium induces cell cycle arrest, apoptosis, and autophagy.

HY-117783

Y-05460M-A	Antibiotic	Infection
Y-05460M-A is a substituted isocoumarin antibiotic. Y-05460M-A exhibits inhibitory activity against Gram-positive and Gram-negative bacteria. Y-05460M-A is cytotoxic against P388 lymphatic leukemia. Y-05460M-A also has antiulcer activity. Y-05460M-A is a one-carbon lower homologue of PM-04128. Y-05460M-A can be achieved from N-Boc-L-valine .

HY-N14959

Deacetylravidomycin N-oxide	Antibiotic Bacterial	Infection Cancer
Deacetylravidomycin N-oxide is an antibiotic that can be produced by Streptomyces ravidus S50905. Deacetylravidomycin N-oxide is active against Gram-positive bacteria but inactive against Gram-negative bacteria. Deacetylravidomycin N-oxide has antitumor activity against P388 leukemia and methamphetamine A fibrosarcoma .

HY-N10206

11-epi-Chaetomugilin I	Endogenous Metabolite	Cancer
11-epi-Chaetomugilin I is a metabolite found in Chaetomium globosum. 11-epi-Chaetomugilin I exhibits significant cytotoxic activity against the murine P388 leukemia cell line, the human HL-60 leukemia cell line, the murine L1210 leukemia cell line, and the human KB epidermoid carcinoma cell line .

HY-167671

BE-10988	Topoisomerase	Cancer
BE-10988 is a DNA topoisomerase inhibitor. BE-10988 inhibits the growth of Doxorubicin (HY-15142A)-resistant and vincristine-resistant P388 mouse leukemia cell lines by increasing the formation of DNA topoisomerase complexes .

HY-123325

Kapurimycin A1	Antibiotic Bacterial	Infection Cancer
Kapurimycin A1 is an anbitiotic that can be isolated from Streptomyces. Kapurimycin A1 has a significant inhibitory effect on Gram-positive bacteria, exhibits cytotoxicity to cultured mammalian cells, and shows strong antitumor activity against the mouse leukemia P388 cell line .

HY-N1649

2,3,2'',3''-Tetrahydroochnaflavone	Others	Cancer
2,3,2'',3''-Tetrahydroochnaflavone is a biflavonoid, which can be isolated from the leaves of Quintinia acutifolia. 2,3,2'',3''-Tetrahydroochnaflavone shows some cytotoxicity against P388 murine lymphocytic leukemia cells, with an IC₅₀ of 8.2 µg/mL .

HY-113771

Saquayamycin C	Bacterial	Infection Cancer
Saquayamycin C has antimicrobial effect, but it has weaker effect against Gram-negative bacteria. Saquayamycin C has inhibitory effect on leukemia P388 cells and Adriamycin-resistant P388 cells .

HY-N13870

Saquayamycin A1	Bacterial	Infection Cancer
Saquayamycin A1 has antimicrobial effect, but it has weaker effect against Gram-negative bacteria. Saquayamycin A1 has inhibitory effect on leukemia P388 cells and Adriamycin-resistant P388 cells .

HY-N13868

Saquayamycin C1	Bacterial	Infection Cancer
Saquayamycin C1 has antimicrobial effect, but it has weaker effect against Gram-negative bacteria. Saquayamycin C1 has inhibitory effect on leukemia P388 cells and Adriamycin-resistant P388 cells .

HY-N13941

Baciphelacin	Bacterial	Infection Cancer
Baciphelacin is mainly resistant to gram-positive bacteria and has the activity of inhibiting Newcastle disease virus and leukemia P-388 cells .

HY-N14621

Harzialacton A	Others	Cancer
Harzialacton A has weak cytotoxicity to P388 leukemia cells with ED₅₀ of > 100 μg/mL .

HY-N13878

Anguinomycin B	Antibiotic Bacterial	Infection
Anguinomycin B is an antitumor antibiotic that shows highly cytotoxic to murine P388 leukemia cells .

HY-N14720

Demethylolivomycin A	Antibiotic Bacterial	Infection Cancer
Demethylolivomycin A is an antitumor antibiotic. Demethylolivomycin A has anti-Gram-positive bacteria and anti-leukemia P388 activity .

HY-N14522

Gilvocarcin E	Bacterial	Infection Cancer
Gilvocarcin E has anti-Gram-positive bacterial activity and can inhibit sarcoma 180 and P388 leukemia cells .

HY-126170

Valanimycin	Antibiotic Bacterial	Infection Cancer
Valanimycin is an antibiotic, which inhibits Escherichia coli (BE1121) through interaction with DNA. Valanimycin exhibits cytotoxicity to mouse leukemia L1210, P388/S (doxorubicin (HY-15142A)-sensitive), and P388/ADR (doxorubicin-resistant), with IC₅₀ of 0.79, 2.65, and 1.44 μg/mL, respectively. Valanimycin exhibits antitumor efficacy against ehrlich ascites tumors or L1210 in mice .

HY-118726

Luotonin F	Topoisomerase	Cancer
Luotonin F is an alkaloid found in the aerial parts of the P. nigellastrum Bunge. Luotonin F shows cytotoxic activity against mouse leukemia P-388 cells by inhibiting human topoisomerase II .

HY-135137

Leptosin I	Others	Cancer
Leptosin I is found in the strain of Leptosphaeria sp. OUPS-4. Leptosin I inhibits Leukemia lymphocyte P388 in culture with an ED₅₀ of 1.13 μg/mL .

HY-N13894

Auramycin A	Antibiotic Bacterial	Infection Cancer
Auramycin A, an anthracycline antibiotic that shows marked antibacterial activity against Gram-positive bacteria. Auramycin A also exhibits antitumor activity against P388 and L1210 leukemia in mice .

HY-N14303

16-Methyloxazolomycin	Antibiotic Bacterial	Infection Cancer
16-Methyloxazolomycin is an antibiotic. 16-Methyloxazolomycin has the effect of resisting bacteria and algae. 16-Methyloxazolomycin against leukemia P388 and human lung adenocarcinoma cells .

HY-12459

Pyrindamycin B	Bacterial	Infection
Pyrindamycin B is an antibiotic, actives against gram-positive and gram-negative bacterias, and exhibits strong therapeutic effects against both agent-sensitive and resistant cells of P388 leukemia in mice .

HY-N14019

Glidobactin B	Antibiotic Bacterial	Infection Cancer
Glidobactin B is an anti-tumor antibiotic. Glidobactin B has the activity against pathogenic fungi and yeast. Glidobactin B also extends the survival of mice inoculated with leukemia P388 cells .

HY-N14023

Glidobactin G	Antibiotic Fungal	Infection Cancer
Glidobactin G is an anti-tumor antibiotic. Glidobactin G has the activity against pathogenic fungi and yeast. Glidobactin G also extends the survival of mice inoculated with leukemia P388 cells .

HY-N14022

Glidobactin F	Antibiotic Fungal	Infection Cancer
Glidobactin F is an anti-tumor antibiotic. Glidobactin F has the activity against pathogenic fungi and yeast. Glidobactin F also extends the survival of mice inoculated with leukemia P388 cells .

HY-N0128R

Sclareol (Standard)	Reference Standards Apoptosis	Cancer
Sclareol (Standard) is the analytical standard of Sclareol. This product is intended for research and analytical applications. Sclareol is isolated from Salvia sclarea with anticarcinogenic activity. Sclareol shows strong cytotoxic activity against mouse leukemia (P-388), human epidermal carcinoma (KB) cells and human leukemia cell lines. Sclareol induces cell apoptosis .

HY-N13895

Auramycin B	Antibiotic Bacterial	Infection Cancer
Auramycin B, an anthracycline antibiotic that shows marked antibacterial activity against Gram-positive bacteria. Auramycin B also exhibits antitumor activity against P388 and L1210 leukemia in mice .

HY-N14095

Curromycin A	Bacterial HIV	Infection Cancer
Curromycin A has antibacterial activity against Gram-positive bacteria such as Bacillus subtilis. Curromycin A can inhibit the replication of human immunodeficiency virus (HIV), inhibit mouse melanoma B16 and leukemia P388 cells .

HY-N14496

Nisamycin	Bacterial	Infection Cancer
Nisamycin has stronger anti-Gram-positive bacteria and weaker anti-fungal and individual Gram-negative bacteria activities. Nisamycin has weak cytotoxic effect. The IC₅₀ of mouse leukemia P388 cells is 4.8 μg/mL .

HY-N14110

Curromycin B	Bacterial HIV	Infection
Curromycin B has antibacterial activity against Gram-positive bacteria such as Bacillus subtilis. Curromycin B can inhibit the replication of human immunodeficiency virus (HIV), inhibit mouse melanoma B16 and leukemia P388 cells .

HY-P1709

Protactin	Bacterial	Infection
Protactin is a pentapeptide lactone produced by Streptomyces cucumeris strain L703-4 (ATCC 53784) with significant antioxidant properties. Protactin can be converted to actinomycin Zp by ferrocyanide oxidation. Actinomycin Zp exhibits potent antibacterial activity in vitro and has significant antitumor effects against P-388 leukemia in a mouse model .

HY-126695

Altromycin B	Antibiotic	Infection
Altromycin B is a member of the pluramycin antibiotic family isolated from South African bush soil. Altromycin B shows selective antibacterial activity against Gram-positive bacteria and has in vivo activity against P388 leukemia, colon cancer, lung cancer, and ovarian cancer.

Cat. No.	Product Name	Target	Research Area

HY-P1709

Protactin	Bacterial	Infection
Protactin is a pentapeptide lactone produced by Streptomyces cucumeris strain L703-4 (ATCC 53784) with significant antioxidant properties. Protactin can be converted to actinomycin Zp by ferrocyanide oxidation. Actinomycin Zp exhibits potent antibacterial activity in vitro and has significant antitumor effects against P-388 leukemia in a mouse model .

HY-P11338

Microcyclamide	Endogenous Metabolite	Cancer
Microcyclamide (Compound 1), a cytotoxic cyclic hexapeptide, is a microbial secondary metabolite. Microcyclamide can be isolated from the cyanobacterium Microcystis aeruginosa. Microcyclamide has moderate cytotoxicity against P388 murine leukemia cells with an IC₅₀ of 1.2 μg/mL. Microcyclamide can be used for cancers research .

HY-182259

Montanastatin	Peptides	Cancer
Montanastatin is an antitumor agent that can be isolated from the terrestrial actinomycete Streptomyces anulatus. Montanastatin inhibits the growth of various cancer cells. Montanastatin can be used in research related to lymphocytic leukemia, ovarian cancer, brain cancer, renal cancer, lung cancer, colon cancer and melanoma .

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