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Cat. No.: HY-182259

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Montanastatin

Montanastatin is an antitumor agent that can be isolated from the terrestrial actinomycete Streptomyces anulatus. Montanastatin inhibits the growth of various cancer cells. Montanastatin can be used in research related to lymphocytic leukemia, ovarian cancer, brain cancer, renal cancer, lung cancer, colon cancer and melanoma.

For research use only. We do not sell to patients.

CAS No.: 14410-23-2
Formula: C₃₆H₆₀N₄O₁₂
Molecular Weight:740.88

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Custom Peptide Synthesis

Montanastatin Chemical Structure

CAS No.: 14410-23-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

In Vitro

Montanastatin (Compound 1) inhibits the growth of mouse P388 leukemia cells and a variety of human cancer cell lines, with a GI₅₀ of 7.5 μg/mL for mouse P388 leukemia cells. The human cancer cell lines include OVCAR-3 (GI₅₀ = 1.2 μg/mL), SF-295 (GI₅₀ = 3.3 μg/mL), A-498 (GI₅₀ = 2.0 μg/mL), NCI-H460 (GI₅₀ = 1.4 μg/mL), KM20L2 (GI₅₀ = 1.4 μg/mL) and SK-MEL-5 (GI₅₀ = 1.3 μg/mL)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 14410-23-2
Molecular Weight 740.88
Formula C₃₆H₆₀N₄O₁₂
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Pettit GR, et al. Antineoplastic agents. Part 409: Isolation and structure of montanastatin from a terrestrial actinomycete. Bioorg Med Chem. 1999;7(5):895-899. [Content Brief]

[2]. Montanastatin, cyclo[-(Val-D-Hyv-D-Val-Lac)2-]. Acta Cryst. (2002). E58, 0935-0936.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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