2. Anti-infection Neuronal Signaling GPCR/G Protein
  3. Reverse Transcriptase HIV Opioid Receptor
  4. Corydine

Corydine is a HIV-1 reverse transcriptase inhibitor and μ-opioid receptor (MOR) agonist, with an IC50 of 356.7 μg/mL against HIV-1 reverse transcriptase, an EC50 of 0.51 μM for MOR, and a Ki of 2.82 μM for MOR. Corydine produces antinociceptive effects by inhibiting acetic acid-induced writhing behavior in a MOR-dependent manner. Corydine inhibits the proliferation of cancer cells, mitogen-stimulated lymphocytes and IL-2-dependent cells. Corydine can be used in studies related to human immunodeficiency virus infection, visceral pain, leukemia, melanoma, bladder cancer and colon adenocarcinoma.

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Corydine

Corydine Chemical Structure

CAS No. : 476-69-7

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Based on 1 publication(s) in Google Scholar

Corydine Related Antibodies

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HIV HIV-1 HIV-2

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μ Opioid Receptor/MOR κ Opioid Receptor/KOR δ Opioid Receptor/DOR NOP Receptor/ORL1

  • Biological Activity

  • Purity & Documentation

  • References

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Description

Corydine is a HIV-1 reverse transcriptase inhibitor and μ-opioid receptor (MOR) agonist, with an IC50 of 356.7 μg/mL against HIV-1 reverse transcriptase, an EC50 of 0.51 μM for MOR, and a Ki of 2.82 μM for MOR. Corydine produces antinociceptive effects by inhibiting acetic acid-induced writhing behavior in a MOR-dependent manner. Corydine inhibits the proliferation of cancer cells, mitogen-stimulated lymphocytes and IL-2-dependent cells. Corydine can be used in studies related to human immunodeficiency virus infection, visceral pain, leukemia, melanoma, bladder cancer and colon adenocarcinoma[1][2][3].

IC50 & Target[1][2]

HIV-1

356.7 μg/mL (IC50)

μ Opioid Receptor/MOR

0.51 μM (EC50)

μ Opioid Receptor/MOR

2.82 μM (Ki)

Cellular Effect
Cell Line Type Value Description References
HeLa IC50
> 200 μM
Compound: 2
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
[PMID: 29103873]
HepG2 IC50
> 200 μM
Compound: 2
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 29103873]
KB IC50
> 733 μM
Compound: Corydine
Cytotoxicity against human KB cells after 72 hrs
Cytotoxicity against human KB cells after 72 hrs
[PMID: 11141105]
MGC-803 IC50
> 200 μM
Compound: 2
Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay
Antiproliferative activity against human MGC803 cells after 48 hrs by MTT assay
[PMID: 29103873]
In Vitro

Corydine (5-450 μg/mL; 1 h) inhibits the enzymatic activity of HIV-1 reverse transcriptase in vitro, with an IC50 of 356.8 μg/mL, and reduces the enzymatic activity by 40% at a concentration of 450 μg/mL[1].
Corydine (60 min) binds to and moderately activates the human μ-opioid receptor expressed on the cell membrane of CHO-hMOR, with a Ki value of 2.82 μM and an EC50 value of 0.51 μM[2].
Corydine (24 h) inhibits the proliferation of P388 and L1210 leukemia cells as well as Colon 26 colon cancer cells, with IC50 values of 23.3 μg/mL, 25.9 μg/mL, and 8.4 μg/mL, respectively[3].
Corydine (44 h) inhibits concanavalin A (Con A)-induced splenic lymphocyte proliferation in mice, with an IC50 of 15.7 μg/mL[3].
Corydine (20 h) inhibits the proliferation of mouse IL-2-dependent CTLL2 cells in vitro, with an IC50 of 10.5 μg/mL[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Corydine Related Antibodies
In Vivo

Corydine (5 mg/kg; s.c.; single dose) produces a 51% reduction in acetic acid-induced writhing in male CD1 mice via a mu opioid receptor-dependent mechanism[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CD1 mice (male, 7-8 weeks old, 30-35 g, acetic acid-induced visceral pain model)[2]
Dosage: 5 mg/kg
Administration: s.c.; single dose
Result: Produced a significant 51% reduction in the number of writhes compared to control mice.
Was completely abolished in antinociceptive effect by pretreatment with the mu opioid receptor antagonist naltrexone.
Caused no alterations in general behavior (sedation, motor impairment) at the tested dose.
Molecular Weight

341.40

Formula

C20H23NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=C(OC)C=C2C3=C1C(C(OC)=C(OC)C=C4)=C4C[C@]3([H])N(CC2)C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation
References
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Corydine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Corydine476-69-7Reverse TranscriptaseHIVOpioid ReceptorHuman immunodeficiency virusHIV-1 reverse transcriptase inhibitorμ-opioid receptor agonisthuman immunodeficiency virus infectionvisceral painleukemiamelanomabladder cancercolon adenocarcinomaCD1 miceP388 cellsL1210 leukemia cellsColon 26 colon cancer cellsCTLL2 cellsInhibitorinhibitorinhibit

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