IOB-82  (Synonyms: NSC-146171)

IOB-82 is a bifunctional alkylating agent. IOB‑82 induces marked nuclear and cytoplasmic alterations, elicits severe chromatid and chromosome aberrations, and remodels chromosome ploidy. IOB-82 exerts dose-dependent radiomimetic effects and preferentially cytotoxic to large A-type rat ascites cells. IOB-82 can be applied in the research of melanoma‑derived tumors and leukemia^[1][2].

IOB-82 (3.62 × 10^{, 4}-3.62 × 10^-3 μM/mL; 24 h) induces concentration-dependent morphological damage to HR-18 rat ascites cells, with large A-type cells more severely affected than B-type cells^[2].
IOB-82 (3.62 × 10^-4, 3.62 × 10^-3 μM/mL; 24 h) induces concentration-dependent structural and numerical chromosomal damage to HR-18 rat ascites cells, eliminating polyploid cells and the 85-86 chromosome population, increasing cells with 41-49 chromosomes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

276.16

C₁₂H₁₅Cl₂NO₂

5977-35-5

O=C(C1=CC=C(C)C(N(CCCl)CCCl)=C1)O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Kapou A, et al. 3D QSAR/CoMFA and CoMSIA studies on antileukemic steroidal esters coupled with conformationally flexible nitrogen mustards. J Chem Inf Model. 2008;48(11):2254-2264.

  [2]. Dumitrescu L, et al. Morphological and cytogenetical changes in HR-18 rat ascites cells after in vitro 3-[bis(2-chloroethyl)amino]-4-methylbenzoic acid (NSC-146171; IOB-82) administration. Tumori. 1978;64(4):361-370.