Zosuquidar trihydrochloride (Standard)
Zosuquidar (trihydrochloride) (Standard) is the analytical standard of Zosuquidar (trihydrochloride). This product is intended for research and analytical applications. Zosuquidar (LY335979) trihydrochloride is a P-glycoprotein (P-gp) inhibitor (Ki=59 nM). Zosuquidar trihydrochloride shows anti-tumor activities, and can be used in acute myelogenous leukemia (AML) research.
For research use only. We do not sell to patients.
- Purity: 95%
- CAS No.: 167465-36-3
- Formula: C32H34Cl3F2N3O2
- Molecular Weight:636.99
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Product Information
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Chemical Information
- Purity & Documentation
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Help & FAQs
Product Information
The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.
Chemical Information
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CAS No. 167465-36-3
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Molecular Weight 636.99
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Formula C32H34Cl3F2N3O2
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SMILES
FC1([C@H]2[C@@H]1C3=C([C@@H](C4=CC=CC=C42)N5CCN(CC5)C[C@H](COC6=C7C=CC=NC7=CC=C6)O)C=CC=C3)F.Cl.Cl.Cl
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Synonyms
RS 33295-198 trihydrochloride (Standard); LY-335979 trihydrochloride (Standard)
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. A H Dantzig, et al. Reversal of P-glycoprotein-mediated multidrug resistance by a potent cyclopropyldibenzosuberane modulator, LY335979. Cancer Res. 1996 Sep 15;56(18):4171-9. [Content Brief]
[2]. Ruoping Tang, et al. Zosuquidar restores drug sensitivity in P-glycoprotein expressing acute myeloid leukemia (AML). BMC Cancer. 2008 Feb 13;8:51. [Content Brief]
[3]. Larry D Cripe, et al. Zosuquidar, a novel modulator of P-glycoprotein, does not improve the outcome of older patients with newly diagnosed acute myeloid leukemia: a randomized, placebo-controlled trial of the Eastern Cooperative Oncology Group 3999. Blood. 2010 Nov 18;116(20):4077-85. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Zosuquidar trihydrochloride (Standard) Related Classifications
HY-50671R Related Classifications
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- Zosuquidar trihydrochloride (Standard)
- 167465-36-3
- RS 33295-198 trihydrochloride (Standard)
- LY-335979 trihydrochloride (Standard)
- Reference Standards
- P-glycoprotein
- anti-tumor activity
- acute myelogenous leukemia
- AML
- K562
- HL60
- CCRF-CEM
- CEM/VLB100
- P388
- P388/ADR
- MCF7
- MCF7/ADR
- 2780
- 2780AD
- UCLA-P3
- UCLA-P3.003VLB
- Inhibitor
- inhibitor
- inhibit