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6r-

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (29) Acyltransferase (2) Adenosine Receptor (1) Antibiotic (4) Antifolate (1) Apoptosis (4) Bacterial (4) BCRP (1) Biochemical Assay Reagents (4) CDK (1) Cholinesterase (ChE) (1) COX (1) Dihydrofolate reductase (DHFR) (1) DNA/RNA Synthesis (3) Dopamine Receptor (4) Drug Derivative (5) Drug Intermediate (6) Drug Isomer (1) Drug Metabolite (2) Endogenous Metabolite (10) Environmental Pollutants (1) ERK (1) FAAH (2) Fluorescent Dye (3) Fungal (3) Glucocorticoid Receptor (1) Glycosidase (1) GPR109A (1) HDAC (1) Herbicide (1) Histamine Receptor (1) HIV (1) iGluR (1) Interleukin Related (11) Isotope-Labeled Compounds (15) Keap1-Nrf2 (1) Leukotriene Receptor (2) MDM-2/p53 (1) MEK (2) mGluR (1) Monoamine Oxidase (5) mRNA (1) mTOR (1) P-glycoprotein (1) P2Y Receptor (5) PERK (1) Phosphodiesterase (PDE) (1) Phosphoramidites (3) PI3K (1) PKA (1) Potassium Channel (1) Prostaglandin Receptor (2) PROTAC Linkers (1) Protoporphyrinogen IX oxidase (1) Raf (1) Reactive Oxygen Species (ROS) (1) Reference Standards (14) Reverse Transcriptase (1) SARS-CoV (1) Small Interfering RNA (siRNA) (7) STAT (3) TNF Receptor (1) VEGFR (1)
By Research Areas:	Cancer (19) Cardiovascular Disease (5) Infection (12) Inflammation/Immunology (21) Metabolic Disease (10) Neurological Disease (33)
Click Chemistry:	Alkynes (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (2) Mouse Pre-designed siRNA Sets (1) mRNA (1) Human Pre-designed siRNA Sets (4) Other Phosphoramidite (3) Phosphoramidites (3) siRNAs (7) Interleukin & Receptors (1)

141

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

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Recombinant Proteins

Isotope-Labeled Compounds

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Click Chemistry

Oligonucleotides

Cat. No.	상품명	Target	연구분야	Chemical Structure

HY-P9917

Tocilizumab 40+ Cited Publications Anti-Human IL6r, Humanized Antibody; RG-1569; rhPM-1	Interleukin Related	Inflammation/Immunology Cancer
Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis . Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease) .

HY-A0124A

Sapropterin dihydrochloride 2 Publications Verification (6r)-BH4 dihydrochloride; (6r)-Tetrahydro-L-biopterin dihydrochloride	Endogenous Metabolite	Infection Metabolic Disease Inflammation/Immunology
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin dihydrochloride can aggravate experimental autoimmune encephalomyelitis (EAE) .

HY-P990211

Anti-Mouse IL-6R Antibody (15A7)	Interleukin Related	Inflammation/Immunology Cancer
Anti-Mouse IL-6R Antibody (15A7) is a rat-derived anti-mouse *IL-6R* IgG2b κ type antibody inhibitor. Anti-Mouse IL-6R Antibody (15A7) blocks IL-6 binding to IL-6Rα and inhibits both IL-6 classic and trans-signaling. Anti-Mouse IL-6R Antibody (15A7) can be used for the researches of cancer and inflammation, such as triple-negative breast cancer .

HY-P99112

Satralizumab RG-6168; SA-237	Interleukin Related	Inflammation/Immunology Cancer
Satralizumab is a humanized monoclonal antibody that targets *IL-6R. Satralizumab prevents dTAA formation and progression in rattus norvegicus*. Satralizumab can be used for neuromyelitis optica spectrum disorder (NMOSD) and descending thoracic aorta aneurysm (dTAA) research .

HY-B1175

(2S,5R,6R)-Ticarcillin disodium	Antibiotic Bacterial	Infection
(2S,5R,6R)-Ticarcillin disodium is a semisynthetic antibiotic with bactericidal activities. (2S,5R,6R)-Ticarcillin disodium is the (2S,5R,6R)-enantiomer of Ticarcillin (HY-139805) .

HY-P99385

Vobarilizumab ALX-0061	Interleukin Related	Inflammation/Immunology
Vobarilizumab (ALX-0061) is a humanized bispecific anti-IL-6R and anti-human serum albumin (ALB) monoclonal antibody (mAb) (K_d: 0.19 pM). Vobarilizumab consists of an anti-IL-6R domain and an anti-human serum albumin domain. Vobarilizumab can be used in the research of inflammatory autoimmune diseases, such as rheumatoid arthritis .

HY-101335

DCG-IV	mGluR	Neurological Disease
DCG-IV is a potent agonist of group II mGluRs with EC₅₀s of 0.35 and 0.09 μM for mGlu2R and mGlu3R, reapectively. DCG-IV is also a competitive antagonist at group I (IC₅₀: mGlu1R/5R=389/630 μM) and III receptors (IC₅₀: mGlu4R/6R/7R/8R= 22.5/39.6/40.1/32 μM). DCG-IV has anticonvulsive and neuroprotective effects .

HY-101955A

(2R,6R)-Hydroxynorketamine hydrochloride (2R,6r)-HNK hydrochloride	Drug Metabolite	Neurological Disease
(2R,6R)-Hydroxynorketamine ((2R,6R)-HNK) hydrochloride is an active ketamine metabolite with no NMDAR binding activity. (2R,6R)-Hydroxynorketamine hydrochloride rescues impaired dorsal hippocampal long-term potentiation and restores robust long-term potentiation in the hippocampal SC-CA1 pathway. (2R,6R)-Hydroxynorketamine hydrochloride can be used for research on depression .

HY-P10284

S7	Interleukin Related VEGFR Apoptosis	Cardiovascular Disease Cancer
S7 is an inhibitory polypeptide targeting *IL-6R, which specifically binds to IL-6R* and its A chain (gp80/IL-6RA) to block its signal transduction. S7 inhibits IL-6-mediated anti-apoptosis (apoptosis), angiogenesis and the expression of VEGF-A, blocks related survival signaling pathways, and enhances the sensitivity of cancer cells to chemotherapeutic drugs. S7 can be applied to the research of related diseases such as cervical cancer, multiple myeloma, Kaposi's sarcoma, prostate cancer and basal cell carcinoma .

HY-177063

IL-6-IN-2	Interleukin Related	Infection Inflammation/Immunology
IL-6-IN-2 is an *interleukin-6* (IL-6) inhibitor. IL-6-IN-2 binds to IL-6 at Lys66, Phe74, Gln175, Ser176, and Arg179 via π-π, π-alkyl, hydrogen bond, and hydrophobic interactions to block *IL-6/IL-6R* heterocomplex formation. IL-6-IN-2 exhibits low gastrointestinal absorption rate. IL-6-IN-2 can be used for the research of cytokine release syndrome, covid-19 .

HY-D1480

Crystal Ponceau 6R	Fluorescent Dye	Others
Crystal Ponceau 6R is a red azo dye. Crystal Ponceau 6R used in histology, for staining fibrin with the martius, scarlet and blue (MSB) Trichrome stain .

HY-A0124

Sapropterin (6r)-BH4; (6r)-Tetrahydro-L-biopterin	Endogenous Metabolite	Infection Metabolic Disease Inflammation/Immunology
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin can aggravate experimental autoimmune encephalomyelitis (EAE) .

HY-A0124AR

Sapropterin dihydrochloride (Standard) (6r)-BH4 dihydrochloride (Standard); (6r)-Tetrahydro-L-biopterin dihydrochloride (Standard)	Endogenous Metabolite Reference Standards	Infection Metabolic Disease Inflammation/Immunology
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) dihydrochloride (Standard) is the analytical standard of Sapropterin dihydrochloride (HY-A0124A) . This product is intended for research and analytical applications. Sapropterin dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin dihydrochloride can aggravate experimental autoimmune encephalomyelitis (EAE) .

HY-W578482

(1S,6R)-6-Amino-2,2-difluorocyclohexan-1-ol	Drug Intermediate	Others
(1S,6R)-6-Amino-2,2-difluorocyclohexan-1-ol is a drug intermediate for synthesis of various active compounds.

HY-78055

2-(((3aR,4S,6R,6aS)-6-((5-Amino-6-chloro-2-(propylthio)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol	Drug Intermediate	Others
2-(((3aR,4S,6R,6aS)-6-((5-Amino-6-chloro-2-(propylthio)pyrimidin-4-yl)amino)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethanol is a drug intermediate for synthesis of various active compounds.

HY-168098

P2Y6R antagonist 1	P2Y Receptor	Inflammation/Immunology
P2Y6R antagonist 1 (compound 5ab) is a selective, orally active *P2Y6R* antagonist with an IC₅₀ value of 19.6 nM. P2Y6R antagonist 1 has anti-inflammatory activity .

HY-115429

Calcium dextrofolinate (6r)-Leucovorin calcium; (6r)-Folinic acid calcium	Drug Derivative	Metabolic Disease
Calcium dextrofolinate is a stereoisomer of Calcium folinate. Calcium folinate (Folinic acid calcium) is a biological folic acid and is generally administered along with methotrexate (MTX) as a rescue agent to decrease MTX-induced toxicity .

HY-101924

AVN-492	5-HT Receptor	Neurological Disease
AVN-492 is a very specific and highly-selective antagonist with picomolar affinity to *5-HT6R* (K_i=91 pM).

HY-41071

(6R)-Taltobulin intermediate-9	Drug Intermediate	Cancer
(6R)-Taltobulin intermediate-9 is an intermediate in the synthesis of Taltobulin (HY-15584) .

HY-12296A

(3S,5S,6R)-Navtemadlin (3S,5S,6r)-AMG 232; (3S,5S,6r)-KRT-232	MDM-2/p53	Cancer
(3S,5S,6R)-Navtemadlin is the isomer of Navtemadlin (HY-12296), and can be used as an experimental control. Navtemadlin (AMG 232) is a potent, selective and orally available inhibitor of p53-MDM2 interaction, with an IC₅₀ of 0.6 nM. Navtemadlin binds to MDM2 with a K_d of 0.045 nM .

HY-P99702

Levilimab BCD-089	Interleukin Related	Inflammation/Immunology
Levilimab (BCD-089) is a fully humanized anti-interleukin-6 receptor (IL-6R) monoclonal antibody. Levilimab is an inflammation-alleviating antibody. Levilimab can be used for the research of rheumatoid .

HY-144856S1

Sapropterin-d3 (6r)-BH4-d₃; (6r)-Tetrahydro-L-biopterin-d₃	Isotope-Labeled Compounds Endogenous Metabolite	Metabolic Disease
Sapropterin-d₃ ((6R)-BH4-d₃) is deuterium labeled Sapropterin. Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) .

HY-109051

Arfolitixorin	Endogenous Metabolite	Cancer
Arfolitixorin is a potent 5-Fluorouracil (5-FU) moderator. Arfolitixorin is an immediately active form of Folate, [6R]-5,10-methylenetetrahydrofolate ([6R]-MTHF). Arfolitixorin is potent for the research of metastatic colorectal cancer .

HY-90009C

ent-Tadalafil ent-IC-351	Phosphodiesterase (PDE)	Cancer
ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS). compound (6R,12aS) is a potent PDE5 inhibitor with an IC₅₀ of 0.090 μM, while ent-Tadalafil is inactive at concentrations up to 10 µM .

HY-175816

5-HT6R/FAAH modulator 1	5-HT Receptor FAAH Apoptosis Reactive Oxygen Species (ROS)	Neurological Disease
5-HT6R/FAAH modulator 1 is a selective serotonin 5-HT6 receptor ligand and the fatty acid amide hydrolase (FAAH) enzyme inhibitor. 5-HT6R/FAAH modulator 1 shows a pK_i of 6.33 (5-HT6) and a pIC₅₀ valuesof 6.29 (FAAH). 5-HT6R/FAAH modulator 1 also slightly inhibits acetylcholinesterase (AChE) or butyrylcholinesterase (BChE) enzymes (pIC₅₀ = 5.12). 5-HT6R/FAAH modulator 1 can inhibit apoptosis and reduce ROS levels. 5-HT6R/FAAH modulator 1 can be used for the research of neurological disease, such as Alzheimer’s disease (AD) .

HY-105138

(6R)-Naxifylline (6r)-BG9719; (6r)-CVT-124	Adenosine Receptor	Cardiovascular Disease
(6R)-Naxifylline ((6R)-BG9719) (ENX R-enantiomer) is the R-enantiomer of Naxifylline (HY-19240). (6R)-Naxifylline is a A₁-adenosine antagonist with saluretic activity. (6R)-Naxifylline induces relaxation of spontaneous tone in guinea pig trachea .

HY-124909

(6R)-FR054	Apoptosis	Cancer
(6R)-FR054 is a less active isomer of FR054.

HY-126733

(6R)-Leucovorin (6r)-Folinic acid	Drug Derivative	Others
(6R)-Leucovorin is a derivative of Folic Acid, a vitamin that plays a crucial role in DNA synthesis, DNA repair, and DNA methylation, and also serves as a cofactor in biological reactions involving folate .

HY-P991602

NI-1201 TZLS-501	Interleukin Related	Cancer
NI-1201 is a monoclonal antibody that targets, in the human IL-6R sequence, the epitope recognized by 25F10 for mice. NI-1201 inhibits both *IL-6* cis- and trans-signaling. NI-1201 targets site IIb of hIL-6R. NI-1201 inhibits gp130 binding to IL-6R .

HY-45219

((3aR,4R,6R,6aR)-6-((E)-4-(Hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl isobutyrate Uridine,2',3'-o-(1-methylethylidene)-,4-oxidechemicalbook,5'-(2-methylpropanoate)	Drug Intermediate	Others
((3aR,4R,6R,6aR)-6-((E)-4-(Hydroxyimino)-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl isobutyrate (Uridine,2',3'-o-(1-methylethylidene)-,4-oxidechemicalbook,5'-(2-methylpropanoate)) is a drug intermediate for synthesis of various active compounds.

HY-156252

Antifungal agent 75	Fungal	Infection
Antifungal agent 75 (compound 6r) is a potent antifungal agent against Candida albicans. Antifungal agent 75 significantly inhibits the formation of C. albicans biofilm, increases the permeability of the cell membrane, reduces the ergosterol level of the cell membrane, damages the membrane structure, and destroys the integrity of the cell structure to exert excellent antifungal activity .

HY-14520A

(6S)-Tetrahydrofolic acid (6S)-5,6,7,8-Tetrahydrofolic acid	Endogenous Metabolite	Metabolic Disease
(6S)-Tetrahydrofolic acid is 1000-fold more active than the (6R) form at promoting the binding of fluorodeoxyuridylate to thymidylate synthase and 600-fold more active as a growth factor of P. cerevisiae. (6S)-Tetrahydrofolic acid also has a low affinity and high dissociation rate for folate-binding protein .

HY-130138B

(5S,6R)-DiHETEs (5S,6r)-(11E)-DiHETE	Leukotriene Receptor	Inflammation/Immunology
(5S,6R)-DiHETEs is the isomer of (5S,6R)-DiHETE (HY-130138A). (5S,6R)-DiHETE can be recognized by leukotriene receptors (LTD4 receptors). (5S,6R)-DiHETE can induce guinea pig isolated ileum contraction with an EC₅₀ of 1.3 μM, and this effect can be inhibited by LTD4 receptor antagonists .

HY-107330R

(6R,7S)-Cefminox sodium heptahydrate (Standard)	Reference Standards Antibiotic	Others
(6R,7S)-Cefminox (sodium heptahydrate) (Standard) is the analytical standard of (6R,7S)-Cefminox (sodium heptahydrate). This product is intended for research and analytical applications. (6R,7S)-Cefminox sodium heptahydrate is an isomer of Cefminox sodium heptahydrate. Cefminox sodium heptahydrate is a β-lactam cephalosporin antibiotic, which exhibits a broad spectrum of antibacterial activity[1].

HY-CE00186

(2S,6R,10R)-Trimethyl-hendecanoyl-CoA (2S,6r,10R)-Trimethyl-hendecanoyl-coenzyme A	Biochemical Assay Reagents	Others
(2S,6R,10R)-Trimethyl-hendecanoyl-CoA ((2S,6R,10R)-Trimethyl-hendecanoyl-coenzyme A) is a fatty acyl-CoA.

HY-146939S

CER7-2’R,6R-d9	Isotope-Labeled Compounds	Others
CER7-2’R,6R-d₉ is deuterium labeled CER7-2’R,6R.

HY-146940S

CER7-2’S,6R-d9	Isotope-Labeled Compounds	Others
CER7-2’S,6R-d₉ is deuterium labeled CER7-2’S,6R.

HY-130138A

(5S,6R)-DiHETE	Leukotriene Receptor	Inflammation/Immunology
(5S,6R)-DiHETE is an enantiomer of (5,6)-DiHETEs. (5S,6R)-DiHETE can be recognized by leukotriene receptors (LTD4 receptors). (5S,6R)-DiHETE can induce guinea pig isolated ileum contraction with an EC₅₀ of 1.3 μM, and this effect can be inhibited by LTD4 receptor antagonists .

HY-B1175R

(2S,5R,6R)-Ticarcillin disodium (Standard)	Reference Standards Antibiotic Bacterial	Infection
(2S,5R,6R)-Ticarcillin disodium (Standard) is the analytical standard of (2S,5R,6R)-Ticarcillin disodium. This product is intended for research and analytical applications. (2S,5R,6R)-Ticarcillin disodium is a semisynthetic antibiotic with bactericidal activities. (2S,5R,6R)-Ticarcillin disodium is the (2S,5R,6R)-enantiomer of Ticarcillin (HY-139805).

HY-168382A

5S(6R)-EET	Prostaglandin Receptor Endogenous Metabolite	Others
5S(6R)-EET is the metabolite of Arachidonic acid (HY-109590). 5S(6R)-EET activates the synthesis of endogenous prostaglandin (PGE2), which inhibits the Na ⁺ absorption, increases the intracellular Ca ²⁺, and promotes the depolarization of transmembrane voltage. 5S(6R)-EET is more active than 5R(6S)-EET (HY-168382) .

HY-12625A

MIV-6R	Others	Others
MIV-6R is an optimized small molecule inhibitor of menin-mixed lineage leukemia (MLL) interaction with IC₅₀ = 56 nM, and its specific mechanism of action activity has been validated in MLL leukemia cells.

HY-N13594

(6R,9R)-3-Oxo-α-ionol glucoside	Others	Others
(6R,9R)-3-Oxo-α-ionol glucoside is a natural product .

HY-107330

(6R,7S)-Cefminox sodium heptahydrate 1 Publications Verification	Antibiotic	Others
(6R,7S)-Cefminox sodium heptahydrate is an isomer of Cefminox sodium heptahydrate. Cefminox sodium heptahydrate is a β-lactam cephalosporin antibiotic, which exhibits a broad spectrum of antibacterial activity .

HY-W739789

(6R)-Tetrahydro-L-biopterin sulfate	Biochemical Assay Reagents	Others
(6R)-Tetrahydro-L-biopterin (sulfate) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-N9871

(6R,9S)-3-Oxo-α-ionol β-D-glucopyranoside	Others	Others
(6R,9S)-3-Oxo-α-ionol β-D-glucopyranoside is a natural product .

HY-172213

(3S,6R)-NML	iGluR	Neurological Disease
(3S,6R)-NML is a NMDA receptor antagonist, with pIC50s of 4.8 (GluN1-GluN2A), 4.6 (GluN1-GluN2B), 5.0 (GluN1-GluN2C), 5.0 (GluN1-GluN2D) respectively. (3S,6R)-NML can be used for depression research .

HY-116494A

(6R)-ML753286	BCRP	Cancer
(6R)-ML753286 is an isomer of ML753286 (HY-116494). ML753286 is an orally active and selective BCRP (Breast cancer resistance protein) inhibitor with an IC₅₀ of 0.6 μM. ML753286 has high permeability and low to medium clearance in rodent and human liver S9 fractions, and is stable in plasma cross species .

HY-109051C

Arfolitixorin sulfate	Endogenous Metabolite	Cancer
Arfolitixorin sulfate is a potent 5-Fluorouracil (5-FU) moderator. Arfolitixorin sulfate is an immediately active form of Folate, [6R]-5,10-methylenetetrahydrofolate ([6R]-MTHF). Arfolitixorin sulfate is potent for the research of metastatic colorectal cancer .

HY-I0108

2-(((3aR,4S,6R,6aS)-6-Amino-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol oxalate	Drug Intermediate	Others
2-(((3aR,4S,6R,6aS)-6-Amino-2,2-dimethyltetrahydro-4H-cyclopenta[d][1,3]dioxol-4-yl)oxy)ethan-1-ol oxalate is a drug intermediate for synthesis of various active compounds.

HY-P991519

VDJ001	Interleukin Related	Inflammation/Immunology
VDJ001 is a high-affinity humanized anti-IL-6R monoclonal antibody. VDJ001 can be used for the study of rheumatoid arthritis .

Cat. No.	상품명	Category	Target	Chemical Structure

HY-A0124A

Sapropterin dihydrochloride 2 Publications Verification (6r)-BH4 dihydrochloride; (6r)-Tetrahydro-L-biopterin dihydrochloride	Cardiovascular Disease Classification of Application Fields Disease Research Fields	Endogenous Metabolite
Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) dihydrochloride is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin dihydrochloride can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin dihydrochloride can aggravate experimental autoimmune encephalomyelitis (EAE) .

HY-109051

Arfolitixorin	Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite
Arfolitixorin is a potent 5-Fluorouracil (5-FU) moderator. Arfolitixorin is an immediately active form of Folate, [6R]-5,10-methylenetetrahydrofolate ([6R]-MTHF). Arfolitixorin is potent for the research of metastatic colorectal cancer .

HY-14520A

(6S)-Tetrahydrofolic acid (6S)-5,6,7,8-Tetrahydrofolic acid	Human Gut Microbiota Metabolites Microorganisms Endogenous metabolite Source Classification	Endogenous Metabolite
(6S)-Tetrahydrofolic acid is 1000-fold more active than the (6R) form at promoting the binding of fluorodeoxyuridylate to thymidylate synthase and 600-fold more active as a growth factor of P. cerevisiae. (6S)-Tetrahydrofolic acid also has a low affinity and high dissociation rate for folate-binding protein .

HY-N13594

(6R,9R)-3-Oxo-α-ionol glucoside	Terpenoids Sesquiterpenes Rosaceae Plants Rosa rugosa Thunb. Source Classification	Others
(6R,9R)-3-Oxo-α-ionol glucoside is a natural product .

HY-N9871

(6R,9S)-3-Oxo-α-ionol β-D-glucopyranoside	Terpenoids Sesquiterpenes Euphorbiaceae Plants Macaranga tanarius (L.) Muell. Arg. Source Classification	Others
(6R,9S)-3-Oxo-α-ionol β-D-glucopyranoside is a natural product .

HY-109051C

Arfolitixorin sulfate	Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
Arfolitixorin sulfate is a potent 5-Fluorouracil (5-FU) moderator. Arfolitixorin sulfate is an immediately active form of Folate, [6R]-5,10-methylenetetrahydrofolate ([6R]-MTHF). Arfolitixorin sulfate is potent for the research of metastatic colorectal cancer .

HY-107579R

Acifran (Standard) AY 25712 (Standard)	Human Gut Microbiota Metabolites Endogenous metabolite Source Classification	Reference Standards GPR109A
(2S,5R,6R)-Ticarcillin (disodium) (Standard) is the analytical standard of (2S,5R,6R)-Ticarcillin (disodium). This product is intended for research and analytical applications. (2S,5R,6R)-Ticarcillin disodium is an injectable antibiotic for the treatment of Gram-negative bacteria, particularly Pseudomonas aeruginosa. It is also one of the few antibiotics capable of treating Stenotrophomonas maltophilia infections.

HY-N17473

(+)-(6R)-Eucomegastigmane A	Structural Classification Eucommia ulmoides Oliver Terpenoids Sesquiterpenes Eucommiaceae Plants Source Classification	Drug Derivative
(+)-(6R)-Eucomegastigmane A (Compound 1a) is a grandisinane enantiomer found in the leaves of Eucommia ulmoides .

HY-N17395

(6R,7R)-Epoxy-1-oleanen-3-ol	Triterpenes Structural Classification Boswellia ovalifoliolata N.P.Balakr. & A.N.Henry Terpenoids Plants Burseraceae Source Classification	TNF Receptor Interleukin Related
(6R,7R)-Epoxy-1-oleanen-3-ol is a triterpenoid that can be found in Boswellia ovalifoliolata, exhibiting anti-inflammatory activity. (6R,7R)-Epoxy-1-oleanen-3-ol inhibits TNF-α, *IL-6, IL-8, and NO production in LPS (HY-D1056)-activated murine neutrophils. (6R,7R)-Epoxy-1-oleanen-3-ol* can be used for the research on inflammatory conditions .

HY-N2383

Validamine (1R,2S,3S,4S,6r)-4-Amino-6-(hydroxymethyl)cyclohexane-1,2,3-triol	Microorganisms Ketones, Aldehydes, Acids Source Classification	Glycosidase
Validamine competitively inhibits β-glucosidase in a pH-dependent and dose-dependent manner, with an IC₅₀ value of 2.92mM, and the maximum inhibitory ability is at the optimum pH value of this enzyme .

HY-N10167

*7-(6'R-Hydroxy-3',7'-dimethylocta-2',7'-dienyloxy)coumarin*	Rutaceae Coumarins Phenylpropanoids Citrus medica L. Plants Source Classification	Others
7-(6'R-Hydroxy-3',7'-dimethylocta-2',7'-dienyloxy)coumarin is a natural product .

HY-N19882

*(1'S,6'R)-4-(2',2',6'-Trimethyl-6'-vinylcyclohexyl)-2-butanone*	Structural Classification Nicotiana tabacum L. Terpenoids Sesquiterpenes Solanaceae Plants Source Classification

HY-N17427

(R)-(22E,24R)-Ergosta-7,9(11),22-triene-3β,5α,6β-triol	Structural Classification Natural Products Microorganisms Source Classification	Others
(R)-(22E,24R)-Ergosta-7,9(11),22-triene-3β,5α,6β-triol (compound 3) is a sterol that can be found in of Grifola frondosa .

HY-N15679

Anhydrolutein I Deoxylutein II; (3R,6'R)-3-Hydroxy-3',4'-didehydro-β,γ-carotene	Natural Products Capsicum annuum L. Solanaceae Plants Source Classification	Drug Derivative
Anhydrolutein I is a dehydration product of Lutein (HY-N6947). Anhydrolutein I can be isolated from the extract of steam-cooked sorrel .

Cat. No.	상품명	Chemical Structure

HY-144856S1

Sapropterin-d3
Sapropterin-d₃ ((6R)-BH4-d₃) is deuterium labeled Sapropterin. Sapropterin ((6R)-BH4) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) .

HY-146939S

CER7-2’R,6R-d9
CER7-2’R,6R-d₉ is deuterium labeled CER7-2’R,6R.

HY-146940S

CER7-2’S,6R-d9
CER7-2’S,6R-d₉ is deuterium labeled CER7-2’S,6R.

HY-11018S2

Risperidone-d6
Risperidone-d6 (R 64 766-d6) is the deuterium labeled Risperidone (HY-11018). Risperidone is a serotonin 5-HT₂ receptor blocker, P-Glycoprotein inhibitor and potent dopamine D₂ receptor antagonist, with K_is of 4.8, 5.9 nM for 5-HT_2A and dopamine D₂ receptor, respectively .

HY-W725464

4-Methylsyringol Gentiobioside-d6
4-Methylsyringol Gentiobioside-d₆ is the deuterium labeled (2S,3R,4S,5S,6R)-2-(2,6-Dimethoxy-4-methylphenoxy)-6-((((2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)methyl)tetrahydro-2H-pyran-3,4,5-triol (HY-W725468).

HY-W759099

3-O-a-d-glucosyl isomaltol-d3
3-O-a-d-glucosyl isomaltol-d₃ is the deuterium labeled 1-(3-(((2R,3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)furan-2-yl)ethan-1-one (HY-W715028).

HY-W753480

Phenol rutinoside-d5
Phenol rutinoside-d₅ is the deuterium labeled (2S,3R,4R,5R,6R)-2-Methyl-6-(((2R,3S,4S,5R,6S)-3,4,5-trihydroxy-6-phenoxytetrahydro-2H-pyran-2-yl)methoxy)tetrahydro-2H-pyran-3,4,5-triol (HY-W725466).

HY-146768S

24(R/S),25-Epoxycholesterol-d6
24(R/S),25-Epoxycholesterol-d₆ is deuterium labeled 24(R/S),25-Epoxycholesterol.

HY-12772S3

Hydroxy Itraconazole-d6
Hydroxy Itraconazole-d₆ (R-63373-d₆) is deuterium labeled Hydroxy Itraconazole. Hydroxy Itraconazole (Itraconazole metabolite Hydroxy Itraconazole; R-63373) is an active metabolite of Itraconazole (ITZ), which is a triazole antifungal agent.

HY-B0411S2

Domperidone-13C6
Domperidone- ¹³C₆ (R33812- ¹³C₆) is ¹³C labeled Domperidone. Domperidone (R33812) is an orally active and selective dopamine-2 receptor antagonist. Domperidone acts as an antiemetic and a prokinetic agent through its effects on the chemoreceptor trigger zone and motor function of the stomach and small intestine .

HY-125922S

(22R)-Budesonide-d6
(22R)-Budesonide-d₆ (Dexbudesonide-d₆) is deuterium labeled (22R)-Budesonide. (22R)-Budesonide ((22R)-BUD) is the (22R)-enantiomer of Budesonide (HY-13580). (22R)-Budesonide is a non-halogenated glucocorticoid with high local anti-inflammatory activity .

HY-B0363S1

Nimesulide-13C6
Nimesulide- ¹³C₆ (R805- ¹³C₆) is ¹³C labeled Nimesulide. Nimesulide is a selective COX-2 inhibitor, with IC₅₀s of 70 nM-70 μM in a time-dependent manner, but it shows no effect on COX-1 (IC₅₀ >100 μM). Nimesulide has potent anti-inflammatory, analgesic and antipyretic properties.

HY-14149S

Cisapride-d6
Cisapride-d₆ (R51619-d₆) is deuterium labeled Cisapride. Cisapride (R 51619) is an orally active 5-HT₄ receptor agonist with an EC₅₀ value of 140 nM. Cisapride is a hERG blocker with an IC₅₀ value of 9.4 nM. Cisapride is a gastroprokinetic agent that stimulates gastrointestinal motor activity .

HY-10574S1

Rilpivirine-13C6

Rilpivirine- ¹³C₆ (R278474- ¹³C₆) is ¹³C labeled Rilpivirine. Rilpivirine (R278474) is a potent and specific diarylpyrimidine (DAPY) non-nucleoside reverse transcriptase inhibitor (NNRTI). Rilpivirine has high antiviral activity against wild-type HIV (EC₅₀=0.4 nM) and mutant viruses (EC₅₀=0.1-2.0 nM). Rilpivirine has a high genetic barrier to resistance development of HIV .

HY-W749528

3-Deoxyglucosone-13C6
3-Deoxyglucosone- ¹³C₆ is the ¹³C-labeled (5s,6r)-2,5-dihydroxy-6-(hydroxymethyl)dihydro-2h-pyran-3(4h)-one (HY-W759076).

HY-W700821

Pramipexole impurity 38-d3
Pramipexole impurity 38-d₃ is deuterium labeled (R)-N-(2-Amino-4,5,6,7-tetrahydrobenzo[d]thiazol-6-yl)propionamide .

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