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Cat. No.: HY-162682

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5-HT6R antagonist 4

5-HT6R antagonist 4 (compound 30) is a neutral antagonist of 5-HT6R, with the K_i of 1 nM.

For research use only. We do not sell to patients.

Formula: C₂₀H₂₀FN₃O₂S
Molecular Weight:385.46

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

5-HT6R antagonist 4 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

5-HT6R antagonist 4 (compound 30) is a neutral antagonist of 5-HT6R, with the K_i of 1 nM^[1].

IC₅₀ & Target

5-HT₆ Receptor

All 5-HT Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Astrocyte	IC₅₀	39.3 μM Compound: 30	Cytotoxicity against human astrocytes incubated for 3 hrs by MTT assay Cytotoxicity against human astrocytes incubated for 3 hrs by MTT assay	[PMID: 38936149]
C8-D1A	IC₅₀	37.4 μM Compound: 30	Cytotoxicity against mouse C8D1A cells incubated for 3 hrs by MTT assay Cytotoxicity against mouse C8D1A cells incubated for 3 hrs by MTT assay	[PMID: 38936149]
PC-12	IC₅₀	25.6 μM Compound: 30	Cytotoxicity against rat PC12 cells incubated for 3 hrs by MTT assay Cytotoxicity against rat PC12 cells incubated for 3 hrs by MTT assay	[PMID: 38936149]
SH-SY5Y	IC₅₀	18.5 μM Compound: 30	Cytotoxicity against human SH-SY5Y cells incubated for 3 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells incubated for 3 hrs by MTT assay	[PMID: 38936149]

Chemical Information

Molecular Weight 385.46
Formula C₂₀H₂₀FN₃O₂S
SMILES

FC1=CC(C2=CC=CN2S(=O)(C3=CC(N4CCNCC4)=CC=C3)=O)=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Marcin Drop, et al. 5-HT6 receptor neutral antagonists protect astrocytes: A lesson from 2-phenylpyrrole derivatives. Eur J Med Chem. 2024 Sep 5:275:116615. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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5-HT6R antagonist 4

All 5-HT Receptor Isoforms