MEK/PI3K-IN-1
MEK/PI3K-IN-1 (compound 6r) is a potent MEK/PI3K inhibitor, with IC50 values of 124 nM (MEK1), 130 nM (PI3Kα), and 236 nM (PI3Kδ), respectively. MEK/PI3K-IN-1 suppresses pAKT and pERK1/2 levels. MEK/PI3K-IN-1 shows anti-proliferative activity against tumor cell lines.
For research use only. We do not sell to patients.
- CAS No.: 2281803-28-7
- Formula: C36H37F5IN9O6
- Molecular Weight:913.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All MEK Isoforms
More
Biological Activity
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MEK1 124 ± 11 nM (IC50) |
PI3Kα 130 ± 13 nM (IC50) |
PI3Kδ 236 ± 29 nM (IC50) |
PI3Kβ 1537 ± 188 nM (IC50) |
PI3Kγ 2745 ± 485 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A-375 | IC50 |
10.7 μM
Compound: 6r
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Antiproliferative activity against human A-375 cells assessed as reduction in cell viability measured after 72 hrs by CellTiter-Fluor cell viability assay
Antiproliferative activity against human A-375 cells assessed as reduction in cell viability measured after 72 hrs by CellTiter-Fluor cell viability assay
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[PMID: 34802837] |
| D54 cell line | IC50 |
17.3 μM
Compound: 6r
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Antiproliferative activity against human D54 cells assessed as reduction in cell viability measured after 72 hrs by CellTiter-Fluor cell viability assay
Antiproliferative activity against human D54 cells assessed as reduction in cell viability measured after 72 hrs by CellTiter-Fluor cell viability assay
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[PMID: 34802837] |
| SET-2 | IC50 |
10.7 μM
Compound: 6r
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Antiproliferative activity against human SET-2 cells assessed as reduction in cell viability measured after 72 hrs by CellTiter-Fluor cell viability assay
Antiproliferative activity against human SET-2 cells assessed as reduction in cell viability measured after 72 hrs by CellTiter-Fluor cell viability assay
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[PMID: 34802837] |
Chemical Information
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CAS No. 2281803-28-7
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Molecular Weight 913.63
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Formula C36H37F5IN9O6
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SMILES
O=C(C1=C(C(F)=C(C=C1)F)NC2=CC=C(C=C2F)I)NOCCOCCOCCOCCNC3=NC(N4CCOCC4)=NC(N5C(C(F)F)=NC6=C5C=CC=C6)=N3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MEK/PI3K-IN-1 Related Classifications
HY-144692 Related Classifications
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