1. MAPK/ERK Pathway
    PI3K/Akt/mTOR
    Cell Cycle/DNA Damage
  2. MEK
    PI3K
    PERK
  3. MEK/PI3K-IN-1

MEK/PI3K-IN-1 

Cat. No.: HY-144692
Handling Instructions

MEK/PI3K-IN-1 (compound 6r) is a potent MEK/PI3K inhibitor, with IC50 values of 124 nM (MEK1), 130 nM (PI3Kα), and 236 nM (PI3Kδ), respectively. MEK/PI3K-IN-1 suppresses pAKT and pERK1/2 levels. MEK/PI3K-IN-1 shows anti-proliferative activity against tumor cell lines.

For research use only. We do not sell to patients.

MEK/PI3K-IN-1 Chemical Structure

MEK/PI3K-IN-1 Chemical Structure

CAS No. : 2281803-28-7

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Description

MEK/PI3K-IN-1 (compound 6r) is a potent MEK/PI3K inhibitor, with IC50 values of 124 nM (MEK1), 130 nM (PI3Kα), and 236 nM (PI3Kδ), respectively. MEK/PI3K-IN-1 suppresses pAKT and pERK1/2 levels. MEK/PI3K-IN-1 shows anti-proliferative activity against tumor cell lines[1].

IC50 & Target

MEK1

124 ± 11 nM (IC50)

PI3Kα

130 ± 13 nM (IC50)

PI3Kδ

236 ± 29 nM (IC50)

PI3Kβ

1537 ± 188 nM (IC50)

PI3Kγ

2745 ± 485 nM (IC50)

Molecular Weight

913.63

Formula

C36H37F5IN9O6

CAS No.
SMILES

O=C(C1=C(C(F)=C(C=C1)F)NC2=CC=C(C=C2F)I)NOCCOCCOCCOCCNC3=NC(N4CCOCC4)=NC(N5C(C(F)F)=NC6=C5C=CC=C6)=N3

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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MEK/PI3K-IN-1
Cat. No.:
HY-144692
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