DHFR-IN-8
DHFR-IN-8 (compound 6r) is a dihydrofolate reductase (DHFR) inhibitor that affects purine and thymidylate biosynthesis in cell proliferation and growth. DHFR-IN-8 inhibits methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 (IC50=15.6 ng/mL) in mouse models of systemic infection and thigh infection.
For research use only. We do not sell to patients.
- CAS No.: 3032441-09-8
- Formula: C18H14N6S
- Molecular Weight:346.41
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
0.005 μM
Compound: 6r
|
Cytotoxicity against human HCT-116 cells measured after 72 hrs by MTT assay
Cytotoxicity against human HCT-116 cells measured after 72 hrs by MTT assay
|
[PMID: 37698518] |
| HepG2 | IC50 |
0.12 μM
Compound: 6r
|
Cytotoxicity against human HepG2 cells measured after 72 hrs by MTT assay
Cytotoxicity against human HepG2 cells measured after 72 hrs by MTT assay
|
[PMID: 37698518] |
| HGC-27 | IC50 |
0.001 μM
Compound: 6r
|
Cytotoxicity against human HGC-27 cells measured after 72 hrs by MTT assay
Cytotoxicity against human HGC-27 cells measured after 72 hrs by MTT assay
|
[PMID: 37698518] |
| MCF7 | IC50 |
0.58 μM
Compound: 6r
|
Cytotoxicity against human MCF7 cells measured after 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells measured after 72 hrs by MTT assay
|
[PMID: 37698518] |
Chemical Information
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CAS No. 3032441-09-8
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Molecular Weight 346.41
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Formula C18H14N6S
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SMILES
NC1=NC2=C(C(N)=N1)C(C=CN3CC4=CC=C5SC=NC5=C4)=C3C=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)