3032441-09-8
3032441-09-8
Chemical Structure
DHFR-IN-8
- CAS No.: 3032441-09-8
- Formula:C18H14N6S
- Molecular Weight:346.41
InChIKey: WFHFOKYUKSODFR-UHFFFAOYSA-N
SMILES: NC1=NC2=C(C(N)=N1)C(C=CN3CC4=CC=C5SC=NC5=C4)=C3C=C2
Biological Activity: DHFR-IN-8 (compound 6r) is a dihydrofolate reductase (DHFR) inhibitor that affects purine and thymidylate biosynthesis in cell proliferation and growth. DHFR-IN-8 inhibits methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 (IC50=15.6 ng/mL) in mouse models of systemic infection and thigh infection[1].
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DHFR-IN-8 | DHFR-IN-8 (compound 6r) is a dihydrofolate reductase (DHFR) inhibitor that affects purine and thymidylate biosynthesis in cell proliferation and growth. DHFR-IN-8 inhibits methicillin-resistant Staphylococcus aureus (MRSA) ATCC 43300 (IC50=15.6 ng/mL) in mouse models of systemic infection and thigh infection. | |||||||||||||||||||||
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References
Keywords
