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Cat. No.: HY-107579R

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Acifran (Standard)

Name: Acifran (Standard)
Brand: MedChemExpress
SKU: HY-107579R
Availability: PreOrder

(Synonyms: AY 25712 (Standard))

Acifran (Standard) (AY 25712 (Standard)) is the analytical standard of Acifran (HY-107579). This product is intended for research and analytical applications. Acifran (AY 25712) is an orally active, full GPR109A and GPR109B agonist and hypolipidemic agent. Acifran reduces Forskolin (HY-15371)-induced cAMP elevation, triggers ERK1/ERK2 phosphorylation, and inhibits lipolysis in adipose tissue through G_i-coupled GPCR activation. Acifran is used for research on atherosclerosis, hyperlipidemia, and type 2 diabetes.

For research use only. We do not sell to patients.

CAS No.: 72420-38-3
Formula: C₁₂H₁₀O₄
Molecular Weight:218.21

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Acifran (Standard) Chemical Structure

CAS No.: 72420-38-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Product Information

Information

Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 72420-38-3
Molecular Weight 218.21
Formula C₁₂H₁₀O₄
SMILES

O=C(C(OC1(C)C2=CC=CC=C2)=CC1=O)O
Synonyms

AY 25712 (Standard)
Initial Source
- Endogenous metabolite
- Human Gut Microbiota Metabolites
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

References

[1]. Jung JK, et al. Analogues of acifran: agonists of the high and low affinity niacin receptors, GPR109a and GPR109b. Journal of medicinal chemistry. 2007 Apr 05;50(7):1445-8. [Content Brief]

[2]. Cayen MN, et al. The metabolic disposition of acifran, a new antihyperlipidemic agent, in rats and dogs. Xenobiotica; the fate of foreign compounds in biological systems. 1986 Mar;16(3):251-63. [Content Brief]

[3]. Mahboubi K, et al. Triglyceride modulation by acifran analogs: activity towards the niacin high and low affinity G protein-coupled receptors HM74A and HM74. Biochemical and biophysical research communications. 2006 Feb 10;340(2):482-90.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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