2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. ent-Tadalafil

ent-Tadalafil  (Synonyms: ent-IC-351)

Cat. No.: HY-90009C Purity: 98.14%
COA Handling Instructions

ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS). compound (6R,12aS) is a potent PDE5 inhibitor with an IC50 of 0.090 μM, while ent-Tadalafil is inactive at concentrations up to 10 µM.

For research use only. We do not sell to patients.

ent-Tadalafil Chemical Structure

ent-Tadalafil Chemical Structure

CAS No. : 629652-72-8

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 319 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 319 In-stock
Solid
5 mg USD 290 In-stock
10 mg USD 550 In-stock
50 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

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Description

ent-Tadalafil (ent-IC-351), compound (6S,12aS), is a inactive cis-enantiomer of compound (6R,12aS). compound (6R,12aS) is a potent PDE5 inhibitor with an IC50 of 0.090 μM, while ent-Tadalafil is inactive at concentrations up to 10 µM[1].

IC50 & Target[1]

PDE5

10 μM (IC50)

Molecular Weight

389.40

Appearance

Solid

Formula

C22H19N3O4
CAS No.
SMILES

O=C([[email protected]]1([H])CC2=C([[email protected]](C3=CC=C(OCO4)C4=C3)N15)NC6=C2C=CC=C6)N(C)CC5=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (642.01 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5681 mL 12.8403 mL 25.6805 mL
5 mM 0.5136 mL 2.5681 mL 5.1361 mL
10 mM 0.2568 mL 1.2840 mL 2.5681 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.34 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.34 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: 98.14%

COA (260 KB) HNMR (274 KB) LCMS (104 KB)

Handling Instructions (2659 KB)
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Keywords:

ent-Tadalafil629652-72-8ent-IC-351Phosphodiesterase (PDE)cis-enantiomer6S,12aSInhibitorinhibitorinhibit

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