BDH2 Antibody (YA8099)
(Synonyms: DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR; UNQ6308)BDH2 Antibody (YA8099) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to BDH2.
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Host:
Mouse
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Isotype:
IgG2a
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Application:
WB, IHC-P, ICC/IF, FC
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Reactivity :
Human, Mouse, Rat
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Formulation:
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Conjugation:
Non-conjugated
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Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
FC
FC: Flow Cytometry
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|---|---|---|---|---|
| Dilution Ratio | 1:500-2000 | 1:50-500 | 1:100-250 | 1:100 |
Product Details
BDH2 Antibody (YA8099) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to BDH2.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Calculated Molecular Weight Predicted band size: 26.5 kDa
Full length human recombinant protein of human BDH2 produced in HEK293T cell.
Endogenous
Affinity purified
Non-conjugated
Unmodified
IgG2a
Product Properties
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Appearance
Liquid
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Formulation
Spplied in PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
BDH2 is a NAD(H)-dependent dehydrogenase/reductase with a preference for cyclic substrates. Catalyzes stereoselective conversion of 4-oxo-L-proline to cis-4-hydroxy-L-proline, likely a detoxification mechanism for ketoprolines. Mediates the formation of 2,5-dihydroxybenzoate (2,5-DHBA), a siderophore that chelates free cytoplasmic iron and associates with LCN2, thereby regulating iron transport and homeostasis while protecting cells against free radical-induced oxidative stress. The iron-siderophore complex is imported into mitochondria, providing an iron source for mitochondrial metabolic processes in particular heme synthesis. May act as a 3-hydroxybutyrate dehydrogenase[1][2].
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Subcellular Localization
Cytoplasm
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Expression
Tissue_Specificity: Detected in liver (at protein level)
Induction: Induced by low iron levels, and down-regulated by elevated iron levels -
Isoforms & Post-Translational Modification
Q9BUT1 has three isomers: Q9BUT1-1: 26724 Da (predicted); Q9BUT1-2: 19209 Da (predicted); Q9BUT1-3: 15626 Da (predicted).
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Subunit
Homotetramer
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SwissProt ID
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Synonyms
DHRS6; EFA6R; PRO20933; SDR15C1; UCPA-OR; UNQ6308
Documentation
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