(5aS,6R,6aR)-MK-8666
(5aS,6R,6aR)-MK-8666 is a selective GPR40 agonist with activity in promoting fatty acid-induced insulin secretion in pancreatic β cells and intestinal enteroendocrine cells. (5aS,6R,6aR)-MK-8666 has been studied for the inhibition of type 2 diabetes and has shown significant blood glucose lowering effects. Although (5aS,6R,6aR)-MK-8666 is considered to have potential inhibitory advantages, its development was stopped in Phase I clinical trials due to liver safety issues.
For research use only. We do not sell to patients.
- CAS No.: 1544739-76-5
- Formula: C29H31NO6S
- Molecular Weight:521.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Biological Activity
Chemical Information
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CAS No. 1544739-76-5
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Molecular Weight 521.62
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Formula C29H31NO6S
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SMILES
OC([C@H]1[C@@]2([H])[C@]1([H])CC3=CC(OCC4=CC(C5=C(C=C(C=C5C)OCCCS(C)(=O)=O)C)=CC=C4)=NC=C32)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(5aS,6R,6aR)-MK-8666 Related Classifications
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