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Cat. No.: HY-156017

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5-HT6R antagonist 1

5-HT6R antagonist 1 (Comopund 8) is a 5-HT6R antagonist (K_i: 5 nM). 5-HT6R antagonist 1 inhibits platelet aggregation. 5-HT6R antagonist 1 has excellent metabolic stability. 5-HT6R antagonist 1 reverses MK-801 (HY-15084B)-induced memory impairments in rats. 5-HT6R antagonist 1 can be used for Alzheimer's disease (AD) research.

For research use only. We do not sell to patients.

Formula: C₁₇H₂₂F₂N₆O
Molecular Weight:364.39

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

5-HT6R antagonist 1 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target

Ki: 5 nM (5-HT6R)^[1]

All 5-HT Receptor Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
Platelet	IC₅₀	75.5 μM Compound: 8	Inhibition of collagen-induced platelet aggregation in rat whole blood preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by aggregometer Inhibition of collagen-induced platelet aggregation in rat whole blood preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by aggregometer	[PMID: 37657272]

Chemical Information

Molecular Weight 364.39
Formula C₁₇H₂₂F₂N₆O
SMILES

NC1=NC(C(OC2=CC(F)=CC=C2F)CC)=NC(N3CCN(C)CC3)=N1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Alzheimer’s Disease Modeling
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by a progressive decline in cognitive functions and loss of specific types of neurons and synapses. Alzheimer's symptoms can be simulated in mice by injecting drugs (such as Aβ) or genetically modified.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sudoł-Tałaj S, et al. Hydrophobicity modulation via the substituents at positions 2 and 4 of 1,3,5-triazine to enhance therapeutic ability against Alzheimer's disease for potent serotonin 5-HT6R agents. Eur J Med Chem. 2023 Nov 15;260:115756. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Minimum order quantity

100 mg

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