2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. 5-HT6R antagonist 1

5-HT6R antagonist 1 (Comopund 8) is a 5-HT6R antagonist (Ki: 5 nM). 5-HT6R antagonist 1 inhibits platelet aggregation. 5-HT6R antagonist 1 has excellent metabolic stability. 5-HT6R antagonist 1 reverses MK-801 (HY-15084B)-induced memory impairments in rats. 5-HT6R antagonist 1 can be used for Alzheimer's disease (AD) research.

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5-HT6R antagonist 1

5-HT6R antagonist 1 화학구조

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5-HT6R antagonist 1 Related Antibodies

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제품 설명

5-HT6R antagonist 1 (Comopund 8) is a 5-HT6R antagonist (Ki: 5 nM). 5-HT6R antagonist 1 inhibits platelet aggregation. 5-HT6R antagonist 1 has excellent metabolic stability. 5-HT6R antagonist 1 reverses MK-801 (HY-15084B)-induced memory impairments in rats. 5-HT6R antagonist 1 can be used for Alzheimer's disease (AD) research[1].

IC50 & Target

Ki: 5 nM (5-HT6R)[1]
Cellular Effect
Cell Line Type Value Description References
Platelet IC50
75.5 μM
Compound: 8
Inhibition of collagen-induced platelet aggregation in rat whole blood preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by aggregometer
Inhibition of collagen-induced platelet aggregation in rat whole blood preincubated for 3 mins followed by collagen stimulation and measured after 6 mins by aggregometer
[PMID: 37657272]
분자량

364.39

화학식

C17H22F2N6O
SMILES

NC1=NC(C(OC2=CC(F)=CC=C2F)CC)=NC(N3CCN(C)CC3)=N1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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5-HT6R antagonist 1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-HT6R antagonist 15-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorADplateletmemory impairmentAlzheimer'sInhibitorinhibitorinhibit

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상품명:
5-HT6R antagonist 1
Cat. No.:
HY-156017
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